A5031646842- Congenital Heart Disease Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Arrest and Resuscitation
- Neuroscience and Neuropharmacology Research
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Acute Kidney Injury Research
- Biochemical effects in animals
- Alzheimer's disease research and treatments
- Infant Development and Preterm Care
- Aortic Disease and Treatment Approaches
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pericarditis and Cardiac Tamponade
- Cardiovascular Conditions and Treatments
- Advanced Fluorescence Microscopy Techniques
- Lanthanide and Transition Metal Complexes
- Anesthesia and Neurotoxicity Research
- Cardiac and Coronary Surgery Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- 14-3-3 protein interactions
- Neurogenesis and neuroplasticity mechanisms
- Long-Term Effects of COVID-19
- Transgenic Plants and Applications
- Advanced Neuroimaging Techniques and Applications
Baylor College of Medicine
2006-2025
Baylor School
2025
Texas Children's Hospital
2009-2024
Total (France)
2009
University of Pennsylvania
2005
Rationale: Persons with obstructive sleep apnea may have significant residual hypersomnolence, despite therapy. Long-term hypoxia/reoxygenation events in adult mice, simulating oxygenation patterns of moderate–severe apnea, result lasting oxidative injury, and proinflammatory responses wake-active brain regions. We hypothesized that long-term intermittent hypoxia activates NADPH oxidase this enzyme serves as a critical source superoxide the oxidation injury hypersomnolence.Objectives: sought...
Oxidative damage caused by reactive oxygen species (ROS) has been proposed to be critically involved in several pathological manifestations of aging, including cognitive dysfunction. ROS, superoxide, are generally considered as neurotoxic molecules whose effects can alleviated antioxidant enzymes. However, ROS also known necessary components the signal transduction cascades underlying normal synaptic plasticity. Therefore, we reasoned that role and enzymes play modulating neuronal processes...
Background While hyperglycemia-induced oxidative stress damages peripheral neurons, technical limitations have, in part, prevented vivo studies to determine the effect of hyperglycemia on neurons central nervous system (CNS). olfactory dysfunction is indicated diabetes, receptor (ORNs) remains unknown. In this study, we utilized manganese enhanced MRI (MEMRI) assess impact axonal transport rates ORNs. We hypothesize that (i) induces and associated with reduced ORNs (ii) activates p38 MAPK...
Calbindin-D28K and/or parvalbumin appear to influence the selective vulnerability of motoneurons in amyotrophic lateral sclerosis (ALS). Their immunoreactivity is undetectable readily damaged human ALS, and differentiated motoneuron hybrid cells [ventral spinal cord (VSC 4.1 cells)] that undergo calcium-dependent apoptotic cell death presence ALS immunoglobulins. To provide additional evidence for role calcium-binding proteins vulnerability, VSC were infected with a retrovirus carrying...
Importance Data are limited regarding adverse reactions after COVID-19 vaccination in patients with a history of multisystem inflammatory syndrome children (MIS-C). The lack vaccine safety data this unique population may cause hesitancy and concern for many families health care professionals. Objective To describe following MIS-C. Design, Setting, Participants In multicenter cross-sectional study including 22 North American centers participating National Heart, Lung, Blood Institute,...
Abstract Objective: Neurodevelopmental follow-up programmes for children with CHD help identify neurodevelopmental impairments and support the delivery of recommended interventions. The Cardiac Outcome Collaborative, Diversity, Equity, Inclusion Special Interest Group surveyed members to assess perceived patient barriers follow-up, previous diversity inclusion education, confidence in caring historically marginalised populations. Methods: A link a Redcap online survey was emailed...
Hypothermic circulatory arrest (HCA) is employed for aortic arch and other complex operations, often with selective cerebral perfusion (SCP). Our previous work has demonstrated real-time evidence of improved brain protection using SCP at 18 degrees C. The purpose this study was to evaluate the utility warmer temperatures (25 C) its impact on operating times.Piglets undergoing cardiopulmonary bypass (CPB) 60 min HCA were assigned three groups: C without SCP, 25 (n=8 animals per group). CPB...
<title>Abstract</title> <bold>Introduction</bold> – Children with congenital heart disease (CHD) have an increased burden of neurodevelopmental delays (ND). However, the neurocognitive outcomes children failure needing transplantation (HTx) in childhood are not well described. <bold>Methods</bold> We performed a single center retrospective cohort study including all undergoing HTx between 01/2017 and 12/2022 at age <underline><</underline>2years, who had developmental follow up assessment...
Abstract In this study we utilized manganese‐enhanced MRI (MEMRI) to evaluate the in vivo transneuronal efficiency of manganese ion (Mn 2+ ) movement as a means assess overall changes neuronal function. We designated extension transfer index (MTI) value. To MTI value an physiology examined both pharmacological agents and different mouse models dysfunction. found that treatment with isoflurane, which attenuates synaptic vesicle release, or memantine, postsynaptic uptake Ca well Mn , resulted...
To investigate the impact of feeding mode on neurodevelopmental outcomes in children with congenital heart defects.A retrospective cohort study 208 disease (CHD), who had surgery from 1 January 2013 until 31 December 2016 at Texas Children's Hospital, Houston, TX, US.University Developmental Outcome Clinic.Standardized cognitive scores were assessed Capute Scales and motor development Revised Gesell Schedules. We analyzed anthropometrics, feeding, surgical complexity, syndrome, gender as...
Previous studies have shown that beta amyloid (Abeta) peptide triggers the activation of several signal transduction cascades in hippocampus, including extracellular signal-regulated kinase (ERK) cascade. In this study we sought to characterize cellular localization phosphorylated, active ERK organotypic hippocampal cultures after acute exposure either Abeta (1-42) or nicotine.We observed and nicotine increased levels distinct localizations. We also examined whether phospho-ERK was regulated...
Abstract Objective: Neurodevelopmental delay is common in children who undergo surgery for Congenital Heart Disease (CHD) infancy. Cardiac associated acute kidney injury (CS-AKI) occurs frequently the paediatric cardiac Intensive care unit (ICU). with worse neurodevelopmental scores and cognitive, language, motor domains CHD. No known data exist regarding association of CS-AKI language subscales. In this study, we explored relationship between receptive expressive as well gross fine delay....
Neurodevelopmental impairment is common after surgery for congenital heart disease (CHD) in infancy. While neurodevelopmental follow-up of high-risk patients has increased, the referral patterns ancillary services following initial evaluation have not been reported. The aim this study to describe rates and at visit our outcomes clinic who underwent CHD during infancy.The Cardiac Developmental Outcomes Program Texas Children's Hospital provides routine longitudinal with developmental...
Neurodevelopmental outcomes programs for children with congenital heart disease (CHD) support early identification and intervention developmental impairments; however, not all eligible attend such programs. The purpose of our study was to examine factors, including sociodemographic, associated cardiac neurodevelopmental program attendance.
Abstract Objective: To determine the prevalence and timing of autism spectrum disorder diagnosis in a cohort congenital heart disease (CHD) patients receiving neurodevelopmental follow-up identify associated risk factors. Method: Retrospective single-centre observational study 361 children undergoing surgery for CHD during first 6 months life. Data abstracted included age at diagnosis, child maternal demographics, medical history. Results: Autism was present 9.1% with CHD, median 34 87.9%...