Jessica Snowden
A5039259000- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Ethics in Clinical Research
- Prenatal Substance Exposure Effects
- Neuroscience of respiration and sleep
- Long-Term Effects of COVID-19
- Health and Medical Research Impacts
- Cerebrospinal fluid and hydrocephalus
- Bacillus and Francisella bacterial research
- Meta-analysis and systematic reviews
- Health Sciences Research and Education
- Maternal Mental Health During Pregnancy and Postpartum
- Vaccine Coverage and Hesitancy
- Vitamin D Research Studies
- Asthma and respiratory diseases
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- COVID-19 Impact on Reproduction
- Kawasaki Disease and Coronary Complications
- Childhood Cancer Survivors' Quality of Life
- COVID-19 and healthcare impacts
- Innovations in Medical Education
- Yersinia bacterium, plague, ectoparasites research
University of Arkansas for Medical Sciences
2010-2025
Duke University
2024
Arkansas Children's Hospital
2010-2024
University of Tennessee Health Science Center
2024
University of Arkansas Medical Center
2021-2023
Alaska Native Tribal Health Consortium
2021
Southcentral Foundation
2021
University of Hawaiʻi at Mānoa
2021
University of Nebraska Medical Center
2010-2019
NOAA Integrated Ocean Observing System
2019
Although clinicians have traditionally used the Finnegan Neonatal Abstinence Scoring Tool to assess severity of neonatal opioid withdrawal, a newer function-based approach - Eat, Sleep, Console care is increasing in use. Whether new can safely reduce time until infants are medically ready for discharge when it applied broadly across diverse sites unknown.In this cluster-randomized, controlled trial at 26 U.S. hospitals, we enrolled with withdrawal syndrome who had been born 36 weeks'...
Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed characterize pediatric PASC enable studies underlying mechanisms that will guide future treatment.
During June 2021, the highly transmissible† B.1.617.2 (Delta) variant of SARS-CoV-2, virus that causes COVID-19, became predominant circulating strain in United States. U.S. pediatric COVID-19-related hospitalizations increased during July-August 2021 following emergence Delta and peaked September 2021.§ As May 12, CDC recommended COVID-19 vaccinations for persons aged ≥12 years,¶ on November 2, were 5-11 years.** To date, clinical signs symptoms, illness course, factors contributing to...
Abstract During the coronavirus disease 2019 (COVID-19) pandemic, we have witnessed profound health inequities suffered by Black, Indigenous, and People of Color (BIPOC). These manifested as differential access to testing early in rates severe death 2–3 times higher than white Americans, and, now, significantly lower vaccine uptake compared with their share population affected COVID-19. This article explores impact these COVID-19 (and underlying cause, structural racism) on acceptance BIPOC...
Electronic learning allows individualized education and may improve student performance. This study assessed the impact of e-modules about infection control congenital infections on medical knowledge.A descriptive was conducted involving third-year students pediatric clerkship. e-Module content in three different formats developed: a text monograph, PowerPoint presentation, narrated lecture. Students' use tracked, as participation infectious disease rotation order rotation. Pre- posttests...
Variation in pediatric medical care is common and contributes to differences patient outcomes. Site-to-site variation the characteristics of infants with neonatal opioid withdrawal syndrome (NOWS) has yet be quantified. Our objective was describe site-to-site maternal-infant characteristics, infant management, outcomes for NOWS.
Importance The function-based eat, sleep, console (ESC) care approach substantially reduces the proportion of infants who receive pharmacologic treatment for neonatal opioid withdrawal syndrome (NOWS). This reduction has led to concerns increased postnatal exposure in treatment. However, effect ESC on hospital outcomes pharmacologically treated NOWS is currently unknown. Objective To evaluate differences and total length stay (LOS) managed with vs usual Finnegan tool. Design, Setting,...
Importance The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae SARS-CoV-2 [PASC] or “Long COVID”) in children young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, potential treatment targets adults. Observations We describe protocol for Pediatric Observational Cohort Study NIH’s RE searching COV ID E nhance R ecovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study caregiver-child...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) seroprevalence studies largely focus on adults, but little is known about spread in children. We determined SARS-CoV-2 children and adolescents from Arkansas over the first year of coronavirus disease 2019 (COVID-19) pandemic.
We have previously shown that MyD88 knockout (KO) mice exhibit delayed clearance of Chlamydia muridarum genital infection compared to wild-type (WT) mice. A blunted Th1 response and ineffective suppression the Th2 were also observed in KO The goal present study was investigate specific mechanisms whereby absence leads these effects address compensatory tract ultimately clear MyD88. It NK cells recruited failed produce gamma interferon (IFN-γ) mRNA protein. This defect associated with...
Central nervous system catheter infections are a serious complication in the treatment of hydrocephalus. These commonly caused by Staphylococcus epidermidis and aureus, both known to form biofilms on surface. Our objective was generate novel murine model central catheter-associated biofilm infection using clinical S. aureus isolate characterize nature inflammatory response during growth. Silicone catheters were precoated with facilitate bacterial attachment, whereupon infected or sterile...
Shunt infection is a frequent and serious complication in the surgical treatment hydrocephalus. Previous studies have shown an attenuated immune response to these biofilm-mediated infections. We proposed that IL-10 reduces inflammatory Staphylococcus epidermidis (S. epidermidis) CNS catheter infection. In this study, murine model of catheter-associated S. biofilm was generated based on well-established similar for aureus. The catheters were pre-coated with clinically derived biofilm-forming...
OBJECTIVES: To determine the association of use multiplex assay meningitis/encephalitis panel with clinical management suspected meningitis. METHODS: A cross-sectional study was conducted children 0 to 18 years age who received a lumbar puncture within 48 hours admission for an infectious workup. Patient demographic and presenting information, laboratory studies, medication administration were collected. The primary measure length stay (LOS) secondary measures: time on antibiotics, narrowing...
Preterm birth occurs at excessively high and disparate rates in the United States. In 2016, National Institutes of Health (NIH) launched Environmental influences on Child Outcomes (ECHO) program to investigate influence early life exposures child health. Extant data from ECHO cohorts provides opportunity examine racial geographic variation effects individual- neighborhood-level markers socioeconomic status (SES) gestational age birth. The objective this study was association between...
OBJECTIVES Addressing parental/caregivers’ coronavirus disease 2019 (COVID-19) vaccine hesitancy is critical to improving uptake in children. Common concerns have been previously reported through online surveys, but qualitative data from KII and focus groups may add much-needed context. Our objective was examine factors impacting pediatric COVID-19 decision-making Black, Spanish-speaking, rural white parents/caregivers inform the content design of a mobile application improve uptake. METHODS...
The vision of the AtlantOS Program is to advance Atlantic Ocean observing through co-design by actively supporting collaborative partnerships among networks, data and information systems, wider user communities build on existing initiatives past successes. An ocean process provides a fit-for-purpose system that ensures interconnection scientific experts across disciplines (i.e., observing, modeling, forecasting) key stakeholders. This sharing knowledge disciplines, breaking down silos,...
Background Legalization of recreational cannabis use is expanding across the United States, and prenatal has steadily increased. Evidence suggests that many pregnant individuals to relieve symptoms like nausea. Research demonstrated an association between cannabinoid exposure infant deficits in attention, planning, memory. In other high-risk populations, interventions aimed at increasing parental responsiveness have improved cognitive functioning children. This pilot trial aims utilize a...
Infection is a frequent and serious complication following the treatment of hydrocephalus with CSF shunts, limited therapeutic options because biofilm formation along catheter surface. Here we evaluated possibility that sarA regulatory locus engenders S. aureus more resistant to immune recognition in central nervous system (CNS) based on its reported ability regulate formation. We utilized our established model CNS catheter-associated infection, similar shunt infections seen humans, compare...
To describe coronavirus disease 2019 (COVID-19)-related pediatric hospitalizations during a period of B.1.617.2 (Δ) variant predominance and to determine age-specific factors associated with severe illness.
To identify characteristics of SARS-CoV-2 infection that are associated with hospitalization in children initially evaluated a Pediatric Emergency Department (ED).