A5100447642- Multi-Agent Systems and Negotiation
- Digital Marketing and Social Media
- Sentiment Analysis and Opinion Mining
- Advanced Text Analysis Techniques
- Knowledge Management and Sharing
- Advanced Computational Techniques and Applications
- Text and Document Classification Technologies
- Mobile Agent-Based Network Management
- Neural Networks and Applications
- Time Series Analysis and Forecasting
- Pregnancy and preeclampsia studies
- Service-Oriented Architecture and Web Services
- Web Data Mining and Analysis
- Advanced Algorithms and Applications
- Target Tracking and Data Fusion in Sensor Networks
- Schizophrenia research and treatment
- Topic Modeling
- Mental Health Research Topics
- Data Stream Mining Techniques
- HIV/AIDS Research and Interventions
- Tryptophan and brain disorders
- Business Process Modeling and Analysis
- Pregnancy and Medication Impact
- Outsourcing and Supply Chain Management
- Access Control and Trust
Harvard University
2023-2025
City University of Hong Kong
2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2025
Johns Hopkins University
2019-2024
Shandong University
2024
Air Force Medical University
2010-2024
University of Electronic Science and Technology of China
2019-2024
Sultan Idris Education University
2024
University of California, Los Angeles
2023
Fudan University
2018-2023
Newborn screening for deficiency in the lysosomal enzymes that cause Fabry, Gaucher, Krabbe, Niemann-Pick A/B, and Pompe diseases is warranted because treatment these syndromes now available or anticipated near feature. We describe a multiplex method all five uses newborn-screening cards containing dried blood spots as enzyme source.We used cassette of substrates internal standards to directly quantify enzymatic activities, tandem mass spectrometry product detection. Rehydrated were...
The cross-talk of cluster differentiation (CD)40/CD40 ligand (CD40L) plays a key role in CD4(+) T-cell priming, B-cell terminal maturation, and immunoglobulin (Ig) class-switch recombination. Genetic defects the CD40L lead to disorder characterized by elevated concentrations serum IgM immunodeficiency. Patients with primary biliary cirrhosis (PBC) characteristically show circulating antimitochondrial antibodies (AMAs), liver-infiltrating autoreactive T lymphocytes against mitochondrial...
Background: The Coronavirus Disease 2019 (COVID-19) has been demonstrated as the cause of pneumonia. Nevertheless, it not reported acute myocarditis or fulminant myocarditis. Case Presentation: A 63-year-old male was admitted with pneumonia and cardiac symptoms. He genetically confirmed COVID-19 by testing sputum on first day admission. also had an elevated troponin-I (Trop I) level diffuse myocardial dyskinesia along decreased left ventricular ejection fraction (LVEF) echocardiography....
Background The move away from investigating mental disorders as whole using sum scores to the analysis of symptom-level interactions network has provided new insights into comorbidities. current study explored dynamic between depressive and anxiety symptoms in older Chinese adults with diabetes mellitus (DM) identified central bridge depression-anxiety provide potential targets for prevention intervention depression anxiety. Methods This used a cross-sectional design data 2017–2018 wave...
The goal of this study is to evaluate the analytical and clinical performance a new human immunodeficiency virus antigen antibody (HIV Ag/Ab) test using light-initiated chemiluminescent assay (LiCA®) compare it with well-established Architect® HIV Ag/Ab combo in setting. We used banked samples national reference controls identify ability detect different viral subtypes. Thirteen seroconversion panels were tested early detection HIV. A total 21,042 patient collected diagnostic LiCA®...
Abstract Given inconsistent evidence on preconception or prenatal tobacco use and offspring autism spectrum disorder (ASD), this study assessed associations of maternal smoking with ASD ASD‐related traits. Among 72 cohorts in the Environmental Influences Child Health Outcomes consortium, 11 had diagnosis tobaccosmoking ( n = 8648). 7 Social Responsiveness Scale (SRS) scores traits 2399). Cohorts diagnoses alone (6), (2), both (5). Diagnoses drew from parent/caregiver report, review records,...
Abstract Bronchiolitis is the most common lower respiratory infection in infants, yet its pathobiology remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized with bronchiolitis a 17-center prospective study, and associate them disease severity. We investigate differentially methylated CpGs (DMCs) for characterize DMCs based on their association cell tissues types, biological pathways, gene expression. Lastly, also examine relationships of severity-related...
Tandem mass spectrometry (MS/MS) for newborn screening allows detection of abnormal or excess metabolites in dried blood spots (1)(2)(3)(4)(5). Dried provide a source active enzymes the Fabry (6), Hunter(7), Hurler (7), Pompe(8), Gaucher(9), Niemann–Pick (9), and Tay–Sachs(10) diseases. We investigated whether MS/MS can be used to directly assay spots, this case, galactocerebroside β-galactosidase (GALC; EC 3.2.1.46) Krabbe disease. Development GALC is challenging because low activity cell...
Higher fruit consumption is associated with lower risk of cardiovascular disease (CVD). Substantial uncertainties remain, however, about the associations all-cause mortality and from subtypes CVD major non-vascular diseases, especially in China. In 2004–08, nationwide China Kadoorie Biobank Study recruited > 0.5 million adults aged 30–79 years 10 diverse localities Fresh was estimated using an interviewer-administered electronic questionnaire, data were collected death registries. Among 462...
Sentiment classification aims at mining reviews of customers for a certain product by automatic classifying the into positive or negative opinions. With fast developing World Wide Web applications, sentiment would have huge opportunity to help people analysis customers' opinions from web information. Automatic opinion will benefit both consumers and sellers. Up now, it is still complicated task with great challenge. There are mainly two types approaches classification, machine learning...
With the increasing dilemma of rapid global demand for healthcare services (often in presence limited resources), how to creatively allocate and use resources across a widespread population has become salient issue. Online communities (OHCs) are regarded as potential ICT-based partial solution. In contrast traditional healthcare, online doctor-patient interaction is unlimited terms time space limitations while an OHC exposed whole community. These characteristics key achieving synergistic...
Preterm birth occurs at excessively high and disparate rates in the United States. In 2016, National Institutes of Health (NIH) launched Environmental influences on Child Outcomes (ECHO) program to investigate influence early life exposures child health. Extant data from ECHO cohorts provides opportunity examine racial geographic variation effects individual- neighborhood-level markers socioeconomic status (SES) gestational age birth. The objective this study was association between...
Infants with severe bronchiolitis (i.e., requiring hospitalization) face increased risks of respiratory diseases in childhood. We conduct epigenome-wide association studies a multi-ethnic cohort these infants. identify 61 differentially methylated regions infant blood (<1 year age) associated recurrent wheezing by age 3 (170 cases, 318 non-cases) and/or asthma 6 (112 394 non-cases). These are enriched the enhancers peripheral neutrophils. Several exhibit interaction rhinovirus infection...
Existing empirical studies have drawn inconsistent conclusions about the effect of electronic word-of-mouth valence on consumer decision making. Based attribution theory and prospect theory, this study attempts to explain discrepancy through exploring how product type moderates impact online reviews valence. Our results from a 2 (Positive vs. Negative reviews) (Search goods Experience goods) experiment design show that is asymmetrically moderated by type: The positive greater for search than...
Web content mining is intended to help people discover valuable information from large amount of unstructured data on the Web. Sentiment classification aims product reviews by classifying into positive or negative opinions. Such kind approaches could both consumers and sellers in making their decisions. But it also a complicated task with great challenge. This paper conducted comparison between SVM approach semantic for sentiment Chinese proposed some improvement approaches. Experimental...