A5080804857- Immune Response and Inflammation
- Pluripotent Stem Cells Research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Plant-Microbe Interactions and Immunity
- Inflammasome and immune disorders
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Respiratory Support and Mechanisms
- Block Copolymer Self-Assembly
- Tissue Engineering and Regenerative Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
- Cardiac Ischemia and Reperfusion
- X-ray Diffraction in Crystallography
- Polymer Surface Interaction Studies
- Thermal Regulation in Medicine
- Advanced Polymer Synthesis and Characterization
- Plant Pathogenic Bacteria Studies
- Neonatal Respiratory Health Research
- CRISPR and Genetic Engineering
- Wnt/β-catenin signaling in development and cancer
South China University of Technology
2024-2025
Fudan University
2010-2025
Chongqing Medical University
2025
Children's Hospital of Chongqing Medical University
2025
Shanghai University of Traditional Chinese Medicine
2025
Guizhou University
2019-2020
Guiyang University
2020
Bioengineering Center
2020
Shanghai Institute of Planned Parenthood Research
2016-2018
Shanghai Medical College of Fudan University
2011-2016
Hemorrhagic shock (HS) due to major trauma and surgery predisposes the host development of systemic inflammatory response syndrome (SIRS), including acute lung injury (ALI), through activating exaggerating innate immune response. IL-1β is a crucial proinflammatory cytokine that contributes SIRS ALI. Lung endothelial cells (EC) are one important source IL-1β, production active controlled by inflammasome. In this study, we addressed mechanism underlying HS activation inflammasome in EC. We...
Abstract Immune checkpoint blockade (ICB) has shown considerable promise for treating various malignancies, but only a subset of cancer patients benefit from immune inhibitor therapy because evasion and immune-related adverse events (irAEs). The mechanisms underlying how tumor cells regulate cell response remain largely unknown. Here we show that hexokinase domain component 1 (HKDC1) promotes in CD8 + T cell-dependent manner by activating STAT1/PD-L1 cells. Mechanistically, HKDC1 binds to...
The emergence and widespread occurrence of plant bacterial diseases that cause global production constraints have become major challenges to agriculture worldwide. To promote the discovery development new bactericides, imidazole-labeled 1,3,4-oxadiazole thioethers were first fabricated by integrating crucially bioactive scaffolds imidazole motif skeleton in a single molecular architecture. Subsequently, superior antibacterial compound A6 was gradually discovered possessing excellent...
BackgroundComparing non-inbred autologous and allogeneic induced pluripotent stem cells (iPSCs) their secreted subcellular products among non-human primates is critical for choosing optimal iPSC human clinical trials.MethodsiPSCs were from skin fibroblastic of adult male rhesus macaques belonging to four unrelated consanguineous families. Teratoma generativity, host immune response, wound healing promotion evaluated subsequently.FindingsAll autologous, but no allogeneic, iPSCs formed...
Hemorrhagic shock (HS) due to major trauma predisposes the host development of acute lung inflammation and injury. The vascular endothelium is an active organ that plays a central role in injury through generating reactive oxygen species synthesizing releasing number inflammatory mediators, including leukocyte adhesion molecules regulate neutrophils emigration. Previous study from our laboratory has demonstrated setting sepsis, toll-like receptor-4 (TLR4) signaling can induce TLR2 expression...
Hemorrhagic shock (HS) promotes the development of systemic inflammatory response syndrome and organ injury by activating priming innate immune system for an exaggerated through, as yet, unclear mechanisms. IL-1β also plays important role in post-HS active production is tightly controlled inflammasome. Pyrin, a protein 781 aa with pyrin domain at N-terminal, negatively regulates inflammasome activation through interaction nucleotide-binding oligomerization domain-like receptor (NLRP)....
Abstract BACKGROUND The gradually elevated outbreak of plant bacterial diseases severely limits agricultural products and small amounts pesticides can manage them. Our group has previously synthesized screened the antimicrobial activity diverse 1,3,4‐oxadiazole thioether/sulfone compounds bridged by a sulfur atom at 2‐position 1,3,4‐oxadiazole. However, few studies have evaluated effect eliminating on bioactivity. Herein, novel type N ‐containing heterocyclic pendants‐tagged...
Abstract BACKGROUND The limited amount of agrochemicals targeting plant bacterial diseases has motivated us to study innovative antibacterial surrogates with fresh modes action. Notably, fabrication violent apoptosis inducers control the reproduction pathogenic bacteria should be a feasible way diseases. To achieve this aim, we constructed series novel 18 β ‐glycyrrhetinic piperazine amides based on natural bioactive ingredient acid evaluate in vitro and vivo activity induced behaviors...
Because only a handful of agrochemicals can manage bacterial infections, the discovery and development innovative, inexpensive, high-efficiency antibacterial agents targeting these infections are challenging. Herein, series novel epimeric chiral 18β-glycyrrhetinic acid (GA) ester derivatives with various tertiary amine pendants were designed, synthesized, screened for pharmacological activity. Results showed that some title compounds conferred significantly enhanced activity toward...
Background: Pulmonary ischemia-reperfusion injury (PIRI) is a major cause of fatality post-lung transplantation. Though some long non-coding RNAs (lncRNAs) have been studied in acute lung (ALI), their effects on PIRI remain undefined. The present study aims to explore the underlying mechanism small nucleolar RNA host gene 16 (SNHG16) PIRI. Methods: PIR mouse and OGD/R cell models were established. Exosomes extracted from human pulmonary microvascular endothelial cells (HPMECs). Functional...
Targeting protein for Xklp2 (TPX2) is critical mitosis and spindle assembly because of its control Aurora kinase A (AURKA). However, the regulation TPX2 activity subsequent effects on cancer progression remain unclear. Here, we show that lactylated at K249 in hepatocellular carcinoma (HCC) tumour tissues this process regulated by lactylase CBP delactylase HDAC1. Lactate reduction via either shRNAs targeting lactate dehydrogenase or inhibitor GSK2837808A decreases level lactylation....
This study aimed to evaluate the effects of electroacupuncture (EA) on cancer-induced bone pain (CIBP) and investigate its interaction with STING/IFN-1 pathway. A CIBP model was established in female rats. EA administered for six consecutive days at bilateral L3–L5 Jia Ji points (EX-B2). EA-induced antinociception evaluated through mechanical, thermal, cold sensitivity assessments. significantly increased paw withdrawal threshold (PWT) latency (PWL) rats (P<0.01). In spinal cord rats,...
Endothelial cells (ECs) have great potential in vascular diseases research and regenerative medicine. Autologous human ECs are difficult to acquire sufficient numbers vitro, induced pluripotent stem (iPSCs) offer unique opportunity generate for these purposes. In this work, we present a new efficient method simply differentiate iPSCs into functional ECs, which can respond physiological level of flow inflammatory stimulation on fabricated microdevice. The endothelial-like were differentiated...
Exosomes are a family of extracellular vesicles that secreted from almost all types cells and associated with cell‑to‑cell communication. The present study was performed to investigate the effects human induced pluripotent stem cell‑derived exosomes (hiPSC‑exo) on cell viability, capillary‑like structure formation senescence in endothelial exposed high glucose. were isolated conditional medium hiPSCs confirmed by transmission electron microscopy, nanoparticle tracking analysis western blot...
Abstract BACKGROUND Induced apoptosis is an effective technique that can reprogram cellular physiological and pathological processes to eradicate undesirable cells using their innate systems. Inspired by this, numerous inducers have been developed treat animal diseases, especially in the anticancer field. However, few studies reported on development of inductive agents attack plant pathogens activation apoptosis. With aim exploring discovering target phytopathogens, a cluster...
Heterochronic parabiosis has shown that aging individuals can be rejuvenated by a youthful circulatory system; however, the underlying mechanisms remain unclear. Here, we evaluated effect of exosomes isolated from mouse induced pluripotent stem cells (iPSCs) on angiogenesis in naturally aged mice. To achieve this, angiogenic capacity aortic ring, total antioxidant (TAOC), p53 and p16 expression levels major organs, proliferation adherent bone marrow cells, function content serum mice...
The release of hematopoietic progenitor cells (HPCs) from bone marrow (BM) is under tight homeostatic control. Under stress conditions, HPCs migrate BM and egress into circulation to participate in immune response, wound repair, or tissue regeneration. Hemorrhagic shock with resuscitation (HS/R), resulting severe trauma major surgery, promotes HPC mobilization BM, which, turn, affects post-HS responses. In this study, we investigated the mechanism HS/R regulation BM. Using a mouse model,...
Increasing evidence suggests the consensus that direct in vivo application of induced pluripotent stem cells (iPSCs) is infeasible may not be true. Methods: Teratoma formation and fate were examined 53 normal disease conditions involving brain, lung, liver, kidney, islet, skin, hind limb, arteries. Results: Using classic teratoma generation assays, which require iPSCs to congregated confined, all mouse, human, individualized autologous monkey tested formed teratoma, while iPSC-derived did...
Abstract Recurrent stroke is difficult to treat and life threatening. Transfer of anti‐inflammatory gene a potential therapy strategy for ischemic stroke. Using recombinant adeno‐associated viral vector 1 (rAAV1)‐mediated interleukin 10 (IL‐10), we investigated whether transfer beneficial into the rat cerebral vessels during interventional treatment initial could attenuate brain injury caused by recurrent Male Wistar rats were administered rAAV1‐IL‐10, rAAV1‐YFP, or saline left artery. Three...