A5084258827- Kruppel-like factors research
- Peroxisome Proliferator-Activated Receptors
- Genomics, phytochemicals, and oxidative stress
- Genetic Syndromes and Imprinting
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Neonatal Respiratory Health Research
- S100 Proteins and Annexins
- Advanced Glycation End Products research
- Heme Oxygenase-1 and Carbon Monoxide
- Ion Channels and Receptors
- Plant Stress Responses and Tolerance
- Chemokine receptors and signaling
- Immune cells in cancer
- Transplantation: Methods and Outcomes
- Connexins and lens biology
- Plant Micronutrient Interactions and Effects
- Clinical Nutrition and Gastroenterology
- Hematopoietic Stem Cell Transplantation
- Atherosclerosis and Cardiovascular Diseases
- Lipid metabolism and disorders
University of Pittsburgh
2006-2025
Case Western Reserve University
2016-2022
Yangzhou University
2022
University Hospitals of Cleveland
2019-2020
University Hospitals Cleveland Medical Center
2018-2019
University of Maryland, Baltimore
2008
Rutgers, The State University of New Jersey
2008
Acute lung injury (ALI) is a major component of multiple organ dysfunction syndrome after hemorrhagic shock (HS) resulting from surgery and trauma. The increased susceptibility in HS patients to the development ALI suggests not yet fully elucidated mechanisms that enhance proinflammatory responses and/or suppress anti-inflammatory lung. Alveolar macrophages (AMϕ) are at center pathogenesis HS. We have previously reported HS-activated polymorphonuclear neutrophils (PMNs) interact with...
Trauma/hemorrhagic shock is associated with morbidity and mortality due to dysregulated inflammation, which driven in part by monocytes/macrophages stimulated injury-induced release of damage-associated molecular pattern (DAMP) molecules. MRP8/MRP14 an endogenous DAMP involved various inflammatory diseases, though its mechanism action unclear. Circulating levels human blunt trauma nonsurvivors were significantly lower than those survivors (P < 0.001). Human monocytic THP-1 cells expressed...
The hydrodynamic theory suggests that pain associated with stimulation of a sensitive tooth ultimately involves mechanotransduction as consequence fluid movement within exposed dentinal tubules. To determine whether putative mechanotransducers could underlie in pulpal afferents, we used single-cell PCR approach to screen retrogradely labeled afferents. presence mRNA encoding BNC-1, ASIC3, TRPV4, TRPA1, the α, β, and γ subunits ENaC, two pore K + channels (TREK1, TREK2) TRAAK were screened...
Monocytes are critical effector cells of the innate immune system that protect host by migrating to inflammatory sites, differentiating macrophages and dendritic cells, eliciting responses, killing pathogenic microbes. MCP-1, also known as CCL2, plays an important role in monocyte activation migration. The chemotactic function MCP-1 is mediated binding CCR2 receptor, a member G protein-coupled receptor (GPCR) family. Desensitization GPCR chemokine receptors regulator intensity duration...
Hemorrhagic shock (HS) promotes the development of systemic inflammatory response syndrome and organ injury by activating priming innate immune system for an exaggerated through, as yet, unclear mechanisms. IL-1β also plays important role in post-HS active production is tightly controlled inflammasome. Pyrin, a protein 781 aa with pyrin domain at N-terminal, negatively regulates inflammasome activation through interaction nucleotide-binding oligomerization domain-like receptor (NLRP)....
Abstract Substantial evidence implicates crosstalk between metabolic tissues and the immune system in inception progression of obesity. However, molecular regulators that orchestrate metaflammation both centrally peripherally remains incompletely understood. Here, we identify myeloid Krüppel-like factor 2 (KLF2) as an essential regulator obesity its sequelae. In mice humans, consumption a fatty diet downregulates KLF2 levels. Under basal conditions, myeloid-specific knockout (K2KO) exhibit...
Skeletal muscle is a major determinant of systemic metabolic homeostasis that plays critical role in glucose metabolism and insulin sensitivity. By contrast, despite being user fatty acids, evidence muscular disorders can lead to abnormal lipid deposition (e.g., nonalcoholic liver disease myopathies), our understanding skeletal regulation not well understood. Here we show Krüppel-like factor 15 (KLF15) coordinates pathways central under basal conditions response nutrient overload. Mice with...
Skeletal muscle dynamically regulates systemic nutrient homeostasis through transcriptional adaptations to physiological cues. In response changes in the metabolic environment (e.g., alterations circulating glucose or lipid levels), networks of transcription factors and coregulators are recruited specific genomic loci fine-tune homeostatic gene regulation. Elucidating these mechanisms is particular interest as regulatory pathways can serve potential targets treat disease. The zinc-finger...
The release of hematopoietic progenitor cells (HPCs) from bone marrow (BM) is under tight homeostatic control. Under stress conditions, HPCs migrate BM and egress into circulation to participate in immune response, wound repair, or tissue regeneration. Hemorrhagic shock with resuscitation (HS/R), resulting severe trauma major surgery, promotes HPC mobilization BM, which, turn, affects post-HS responses. In this study, we investigated the mechanism HS/R regulation BM. Using a mouse model,...
Willows (Salix spp.) are promising extractors of cadmium (Cd), with fast growth, high biomass production, and Cd accumulation capacity. However, the molecular mechanisms underlying uptake detoxification currently poorly understood. Analysis among 30 willow genotypes in hydroponic systems showed that S. suchowensis integra hybrids, Jw8-26 Jw9-6, exhibited distinct resistance characteristics. was a Cd-accumulating tolerant willow, while Jw9-6 low relatively Cd-intolerant willow. Therefore,...
Cardiac metabolism is highly adaptive in response to changes substrate availability, as occur during fasting. This metabolic flexibility essential the maintenance of contractile function and under control a group select transcriptional regulators, notably nuclear receptor family factors member PPARα. However, diversity physiologic pathologic states through which heart must sustain suggests possible existence additional regulators that play role matching cardiac energetic demand. Here we show...
Brown adipose tissue (BAT) is a specialized metabolic organ responsible for non-shivering thermogenesis. Recently, its activity has been shown to be critical in systemic health through utilization and consumption of macronutrients. In the face energetically demanding states, flexibility coordination nutrient partitioning requisite survival. this study, we elucidate BAT's differential transcriptional adaptations response multiple challenges demonstrate context-dependent prioritization lipid,...
Substantial evidence implicates crosstalk between metabolic tissues and the immune system, both centrally peripherally, in inception progression of obesity. Nodal factors that orchestrate systemic “metaflammation” remain very incompletely understood. Here, we identify myeloid Krüppel-like factor 2 (KLF2) as an essential regulator obesity its sequelae. Macrophages with KLF2 deletion enrich transcriptional networks associated syndrome. In mice humans, consumption a fatty diet is...