A5103168150- Amyotrophic Lateral Sclerosis Research
- Mitochondrial Function and Pathology
- Muscle Physiology and Disorders
- RNA Research and Splicing
- Kruppel-like factors research
- Gene expression and cancer classification
- Genomic variations and chromosomal abnormalities
- Bioinformatics and Genomic Networks
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Visual perception and processing mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Cholinesterase and Neurodegenerative Diseases
- Cancer Genomics and Diagnostics
- Cardiac Ischemia and Reperfusion
- Protein Degradation and Inhibitors
- Biochemical Acid Research Studies
- Genetic Neurodegenerative Diseases
- Extraction and Separation Processes
- Chemotherapy-induced cardiotoxicity and mitigation
- Peroxisome Proliferator-Activated Receptors
- Reproductive System and Pregnancy
- RNA modifications and cancer
- Neurobiology and Insect Physiology Research
- Advanced Battery Technologies Research
- Neural dynamics and brain function
Amgen (United States)
2019-2022
Gladstone Institutes
2019-2022
University of Florida
2019
Anhui Agricultural University
2019
Zhejiang Academy of Medical Sciences
2019
Marshall University
2019
Case Western Reserve University
2015-2018
Fred Hutch Cancer Center
2008
North Seattle College
2008
University of Washington
2008
Abstract Motivation: Gene Set Enrichment Analysis (GSEA) has been developed recently to capture changes in the expression of pre-defined sets genes. We propose number extensions GSEA, including use different statistics describe association between genes and phenotypes interest. make dimension reduction procedures, such as principle component analysis, identify gene with correlated expression. also address issues that arise when overlap. Results: Our proposals extend range applicability GSEA...
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease characterized by progressive loss of neurons in brainstem and spinal cord. Currently, there no cure or effective treatment for ALS cause unknown majority cases. Neuronal mitochondria dysfunction one earliest features ALS. Mitochondria are highly dynamic organelles that undergo continuous fission, fusion, trafficking turnover, all which contribute to maintenance mitochondrial function. Abnormal dynamics have been...
In humans, chronic glucocorticoid use is associated with side effects like muscle wasting, obesity, and metabolic syndrome. Intermittent steroid dosing has been proposed in Duchenne Muscular Dystrophy patients to mitigate the seen daily intake. We evaluated biomarkers from patients, finding that, compared use, weekend was reduced serum insulin, free fatty acids, branched chain amino as well reduction fat mass despite having similar BMIs. reasoned that intermittent prednisone administration...
Abstract Motivation: Gene-set enrichment analysis (GSEA) can be greatly enhanced by linear model (regression) diagnostic techniques. Diagnostics used to identify outlying or influential samples, and also evaluate fit explore expansion. Results: We demonstrate this methodology on an adult acute lymphoblastic leukemia (ALL) dataset, using GSEA based chromosome-band mapping of genes. Individual residuals, grouped aggregated chromosomal loci, indicate problematic samples potential data-entry...
Skeletal muscle dynamically regulates systemic nutrient homeostasis through transcriptional adaptations to physiological cues. In response changes in the metabolic environment (e.g., alterations circulating glucose or lipid levels), networks of transcription factors and coregulators are recruited specific genomic loci fine-tune homeostatic gene regulation. Elucidating these mechanisms is particular interest as regulatory pathways can serve potential targets treat disease. The zinc-finger...
Circulating corticosteroids orchestrate stress adaptation, including inhibition of inflammation. While pathways governing corticosteroid biosynthesis and intracellular signaling are well understood, less is known about mechanisms controlling plasma transport. Here, we show that hepatocyte KLF15 (Kruppel-like factor 15) controls transport inflammatory responses through direct transcriptional activation
At concentrations found in humans after ingestion of one to two cups green tea, epicatechin-3-gallate (ECG) modulates Na/K-ATPase conformation and activity. Akin ouabain, an archetypal ligand the cardiotonic steroid (CTS) family, ECG also activates protein kinase C epsilon type (PKCε) translocation increases force contraction rat heart. This study evaluated whether, like Na/K-ATPase/Src receptor function triggers pre- postconditioning against ischemia/reperfusion (I/R) injury. In vitro,...
Abstract Heart failure with reduced ejection fraction (HFrEF) is associated high mortality, highlighting an urgent need for new therapeutic strategies. As stress-activated cardiac signaling cascades converge on the nucleus to drive maladaptive gene programs, interdicting pathological transcription a conceptually attractive approach HFrEF therapy. Here, we demonstrate that CDK7/12/13 are critical regulators of activation in heart can be pharmacologically inhibited improve HFrEF. inhibition...
One of the most significant pieces linear infrastructure in China is Middle Route South-to-North Water Diversion Project (MR-SNWDP), a large section which consists an expansive soil slope (ESS) that threatens safety canal. Here, we prepared 144 Sentinel-1 data from May 2017 to July 2022 study behavior ESS canal Huixian City MR-SNWDP. Then, Elastoplastic Deformation model under Wetting and Heating Effects (EDWHE) was employed accurately characterize displacement ESS. The InSAR results...