A5005690590- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Renal Diseases and Glomerulopathies
- Protein Kinase Regulation and GTPase Signaling
- Diabetes Treatment and Management
- Parathyroid Disorders and Treatments
- Sphingolipid Metabolism and Signaling
- Lipid metabolism and disorders
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Connective Tissue Growth Factor Research
- Kruppel-like factors research
- Advanced Glycation End Products research
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Pharmacology and Obesity Treatment
- Apelin-related biomedical research
- Endoplasmic Reticulum Stress and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- TGF-β signaling in diseases
- Atherosclerosis and Cardiovascular Diseases
- Biomedical Research and Pathophysiology
Jikei University Kashiwa hospital
2025
Jikei University School of Medicine
2013-2024
RELX Group (United States)
2022
Japan Institute for Advanced Dentistry
2019-2021
Case Western Reserve University
2017-2020
University Hospitals of Cleveland
2017-2019
University School
2017
Noguchi Hospital
2014
Diabetic nephropathy (DN) not only is a major cause of end-stage renal disease (ESRD) in developing and developed countries but also plays critical role as risk factor for cardiovascular disease. The pathogenesis DN multifactorial remains to be elucidated. It well known that dyslipidemia frequently complicated with diabetes. Recently, has been recognized involved the progression DN. In general, diabetic caused by impaired action lipoprotein lipase (LPL) localized endothelial cells, resulting...
Adipose tissue stores energy in the form of triglycerides. The ability to regulate triglyceride synthesis and breakdown based on nutrient status (e.g., fed versus fasted) is critical for physiological homeostasis dysregulation this process can contribute metabolic disease. Whereas much known about hormonal control cycle, transcriptional regulation not well understood. Here, we show that transcription factor Kruppel-like 15 (KLF15) adipocyte lipid turnover. Mice lacking Klf15 adipose (AK15KO)...
The small GTPase Rho and its downstream effector, Rho-kinase (ROCK), regulate various cellular functions, including organization of the actin cytoskeleton, cell adhesion migration. A pro-inflammatory lipid mediator, lysophosphatidic acid (LPA), is a potent activator Rho/ROCK signalling pathway has been shown to induce expression chemokines molecules (CAMs). In present study, we aimed elucidate precise mechanism by which ROCK regulates LPA-induced expressions functions CAMs. We observed that...
The small GTPase Rho and its effector kinase (ROCK) are involved in the pathogenesis of diabetic kidney disease. has two isoforms: ROCK1 ROCK2. However, it remains unclear which is mainly progression glomerulosclerosis regulation profibrotic mediators. Glomeruli isolated from type 2 db/db mice demonstrated increased gene expression transforming growth factor (TGF)-β downstream Chemical inhibition ROCK suppressed mediators both glomeruli cultured mesangial cells. An investigation mechanisms...
The small GTPase Rho and its downstream effector, Rho-associated coiled-coil containing protein kinase (Rho-kinase), regulate a number of cellular processes, including organization the actin cytoskeleton, cell adhesion, migration. While pharmacological inhibitors Rho-kinase signaling are known to block renal inflammation, molecular basis for this effect is unclear. Here, we provide evidence that proinflammatory TNF-α promotes mesangial expression macrophage colony-stimulating factor (M-CSF),...
Podocyte apoptosis is a key process in the onset of diabetic nephropathy. A significant body evidence shows that Notch signaling pathway plays central role this process. We found Rho-kinase mediates transforming growth factor β (TGF-β)-induced ligand Jag1 expression. Importantly, TGF-β-mediated podocyte was attenuated by inhibition. Mechanistically, regulated induction via extracellular signal-regulated kinase (ERK) 1/2 and c-Jun N-terminal (JNK) but not Smad pathways. Consistently,...
Abstract Background Metformin treatment has a risk factor of reduced serum concentrations vitamin B12 and zinc, indicating its association with homocysteine metabolism. However, this remains to be clarified in patients type 2 diabetes (T2DM) accompanied by kidney dysfunction. Methods This cross-sectional study was conducted 149 T2DM (96 men, 53 women), including diabetic disease. Serum homocysteine, as well B12, folic acid, were measured outpatient patients. The subjects divided into two...
Abstract Substantial evidence implicates crosstalk between metabolic tissues and the immune system in inception progression of obesity. However, molecular regulators that orchestrate metaflammation both centrally peripherally remains incompletely understood. Here, we identify myeloid Krüppel-like factor 2 (KLF2) as an essential regulator obesity its sequelae. In mice humans, consumption a fatty diet downregulates KLF2 levels. Under basal conditions, myeloid-specific knockout (K2KO) exhibit...
Aim: Menopause is a risk factor for cardiovascular disease (CVD) in women because of the reduction endogenous estrogen. Recently, single nucleotide polymorphisms (SNPs) estrogen receptor α (ESR-1) gene (c.454-397T>C) associated with prognosis myocardial infarction postmenopausal were identified; however, mechanism by which genetic variation ESR-1 contributes to pathogenesis CVD unknown. Circulating levels adipokines and inflammatory cytokines predict risk; hence, this study aimed investigate...
Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine with essential roles in cytoskeletal functions. Substantial evidence implicates ROCK as critical regulator the inception and progression of diabetic nephropathy through mechanism involving mesangial fibrosis, podocyte apoptosis, endothelial inflammation. Despite these experimental observations, human data lacking. Here we show that phosphorylated form myosin phosphatase targeting subunit 1 (MYPT1), substrate,...