A5058808692- Plant-Microbe Interactions and Immunity
- Topic Modeling
- Natural Language Processing Techniques
- Plant Pathogenic Bacteria Studies
- Fungal Plant Pathogen Control
- Plant Virus Research Studies
- Plant Disease Resistance and Genetics
- Nanocomposite Films for Food Packaging
- Supramolecular Self-Assembly in Materials
- Synthesis and biological activity
- Antimicrobial agents and applications
- Polymer-Based Agricultural Enhancements
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- X-ray Diffraction in Crystallography
- Domain Adaptation and Few-Shot Learning
- Crystallization and Solubility Studies
- Multimodal Machine Learning Applications
- Supramolecular Chemistry and Complexes
- Bacterial biofilms and quorum sensing
- Legume Nitrogen Fixing Symbiosis
- Diamond and Carbon-based Materials Research
- Plant Stress Responses and Tolerance
- Text and Document Classification Technologies
- Plant Pathogens and Fungal Diseases
Wuhan Polytechnic University
2023-2025
Guizhou University
2016-2025
Boston College
2023-2025
Northwest A&F University
2023-2025
Center of Hubei Cooperative Innovation for Emissions Trading System
2024-2025
Qingdao Agricultural University
2024
Sichuan University
2024
National University of Singapore
2024
Beijing Forestry University
2021-2024
Shenyang Ligong University
2024
Since April 2010, a severe outbreak of duck viral infection, with egg drop, feed uptake decline and ovary-oviduct disease, has spread around the major duck-producing regions in China. A new virus, named BYD was isolated different areas, similar disease reproduced healthy egg-producing ducks, infecting virus. The virus re-isolated from affected ducks replicated well primary embryo fibroblasts Vero cells, causing cytopathic effect. identified as an enveloped positive-stranded RNA size...
Conifers dominate the world's forest ecosystems and are most widely planted tree species. Their giant complex genomes present great challenges for assembling a complete reference genome evolutionary genomic studies. We 25.4-Gb chromosome-level assembly of Chinese pine (Pinus tabuliformis) revealed that its size is mostly attributable to huge intergenic regions long introns with high transposable element (TE) content. Large genes exhibited higher expressions levels. Despite lack recent...
Zika virus–specific antibodies isolated from a single infected patient show postexposure protection in mice and reveal targets for therapy.
We recently reported the critical importance of Rac GTPase-dependent cortical actin rearrangement in augmentation pulmonary endothelial cell (EC) barrier function by sphingosine 1-phosphate (S1P). now describe functional roles for actin-binding proteins cortactin and EC myosin light chain kinase (MLCK) mediating this response. Antisense down-regulation protein expression significantly inhibits S1P-induced enhancement cultured human artery as measured transendothelial electrical resistance...
The Drosophila para sodium channel alpha subunit was expressed in Xenopus oocytes alone and combination with tipE, a putative accessory subunit. Coexpression of tipE results elevated levels currents accelerated current decay. Para/TipE channels have biophysical pharmacological properties similar to those native channels. However, the pharmacology these differs from that vertebrate channels: (a) toxin II Anemonia sulcata, which slows inactivation, binds Para some mammalian affinity (Kd...
A novel simple 1,3,4-oxadiazole-2-carbohydrazide was reported to discover low-cost and versatile antifungal agents. Bioassay results suggested that a majority of the designed compounds were extremely bioactive against four types fungi two kinds oomycetes. This extreme bioactivity highlighted by applausive inhibitory effects 4b, 4h, 5c, 5g, 5h, 5i, 5m, 5p, 5t, 5v Gibberella zeae, affording EC50 values ranging from 0.486 0.799 μg/mL, which superior fluopyram (2.96 μg/mL) comparable those...
Developing multipurpose agricultural chemicals is appealing in crop protection, thus eventually realizing the reduction and efficient usage of pesticides. Herein, an array versatile pyrazole hydrazide derivatives bearing a 1,3,4-oxadiazole core were initially synthesized biologically evaluated antifungal, antioomycetes, antibacterial activities. In addition, ring was replaced by correlative pyrrole, thiazole, indole scaffolds to extend molecular diversity. The results showed that most these...
Plant bacterial diseases can potentially damage agricultural products around the world, and few effective bactericides manage these infections. Herein, to sequentially explore highly antibacterial alternatives, 1,2,3-triazole-tailored carbazoles were rationally fabricated. These compounds could suppress growth of three main intractable pathogens including Xanthomonas oryzae pv (Xoo), X. axonopodis citri (Xac), Pseudomonas syringae actinidiae (Psa) with lower EC50 values 3.36 (3p), 2.87 4.57...
Bacterial biofilms are the root cause of persistent and chronic phytopathogenic bacterial infections. Therefore, developing novel agrochemicals that target biofilm bacteria has been regarded as an innovative tactic to suppress their invasive infection or decrease drug resistance. In this study, a series natural pterostilbene (PTE) derivatives were designed, antibacterial potency antibiofilm ability assessed. Notably, compound C1 displayed excellent in vitro, affording EC50 value 0.88 μg mL-1...
Abstract Controllable and on‐demand delivery of supramolecular systems have received considerable attention in modern agricultural management, especially for managing intractable plant diseases. Here, an intelligent photoresponsive pesticide system is reported based on β ‐cyclodextrin ( ‐CD) azobenzene, which overcomes the resistance phytopathogens caused by irrational use conventional pesticides. Antibacterial bioassays illustrated that designed azobenzene derivative 3a possesses most...
The rapid development of open-source large language models (LLMs) has been truly remarkable. However, the scaling law described in previous literature presents varying conclusions, which casts a dark cloud over LLMs. We delve into study laws and present our distinctive findings that facilitate scale two commonly used configurations, 7B 67B. Guided by laws, we introduce DeepSeek LLM, project dedicated to advancing with long-term perspective. To support pre-training phase, have developed...
Mathematical reasoning poses a significant challenge for language models due to its complex and structured nature. In this paper, we introduce DeepSeekMath 7B, which continues pre-training DeepSeek-Coder-Base-v1.5 7B with 120B math-related tokens sourced from Common Crawl, together natural code data. has achieved an impressive score of 51.7% on the competition-level MATH benchmark without relying external toolkits voting techniques, approaching performance level Gemini-Ultra GPT-4....
Abstract Repeated epidemics caused by bacterial and fungal diseases pose a threat to global crop yields food security, therefore, updating the structure of existing microbicides improving pesticide bioavailability are challenging tasks, perhaps planning develop versatile supramolecular antimicrobial materials. Here, low‐cost multifunctional complex, named FT6@ β ‐CD, is constructed host‐guest encapsulation thienyl‐engineered ingredient (FT6) into ‐cyclodextrin. This integrated architecture...
Clavibacter michiganensis (Cmm), designated as an A2 quarantine pest by the European and Mediterranean Plant Protection Organization (EPPO), incites bacterial canker of tomato, which presently eludes rapid effective control methodologies. Dense biofilms formed Cmm shield internal bacteria from host immune defenses obstruct ingress agrochemicals. Even when agrochemicals disintegrate biofilms, splashing bouncing during application disperse active ingredients away target sites. Herein, we...
Summary Abiotic stress severely hinders plant growth and development, resulting in a considerable reduction crop yields. Salicylic acid (SA) serves as central signal mediating abiotic responses plants. Real‐time fluorescence tracking using specific probes can enhance our understanding of the SA‐triggered modulation underlying these events. However, complicated living microenvironments, selective recognition bioimaging SA is great challenge for scientists due to severe background interference...
We compared stimulus-coupling pathways involved in bovine pulmonary artery (PA) and lung microvascular endothelial cell migration evoked by sphingosine-1-phosphate (S1P), a potent bioactive lipid released from activated platelets, vascular growth factor (VEGF), well-recognized angiogenic factor. S1P-induced was maximum at 1 microM (approximately 8-fold increase with PA endothelium) surpassed the maximal response either VEGF (10 ng/ml) 2.5-fold increase) or hepatocyte (HGF) increase)....
The emergence and widespread occurrence of plant bacterial diseases that cause global production constraints have become major challenges to agriculture worldwide. To promote the discovery development new bactericides, imidazole-labeled 1,3,4-oxadiazole thioethers were first fabricated by integrating crucially bioactive scaffolds imidazole motif skeleton in a single molecular architecture. Subsequently, superior antibacterial compound A6 was gradually discovered possessing excellent...
A novel series of simple 1,3,4-oxadiazoles that bear flexible heterocyclic patterns was prepared, and their biological activities in plant pathogenic bacteria, fungi, oomycetes, Meloidogyne incognita vitro vivo were screened to explore low-cost versatile antimicrobial agents. Screening results showed compounds, such as A0, B0, C4, bioactive against Xanthomonas oryzae pv vivo, bioactivities superior those commercial agents bismerthiazol thiodiazole copper. Their antibacterial mechanisms...
In recent years, naturally occurring tetrahydro-β-carboline (THC) alkaloids and their derivatives have been of biological interest. However, few studies developments reported the use such structures in managing plant bacterial diseases. Herein, an array novel THC containing attractive 1,3-diaminopropan-2-ol pattern were prepared to evaluate antiphytopathogen activity vitro vivo explore innovative antibacterial frameworks. Notably, target compounds exhibited excellent activities against three...
Recent observations on the emergence of drug-resistant plant pathogenic bacteria have highlighted and elicited an acute campaign to develop novel, highly efficient antibiotic surrogates for managing bacterial diseases in agriculture. Thus, a type racemic chiral carbazole derivative containing isopropanolamine pattern was systematically synthesized discover low-cost antibacterial candidates. Screening results showed that compounds 2f, 6c, 2j could significantly suppress growth tested...