A5086313098- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Conditions and Treatments
- Coronary Artery Anomalies
- Cardiovascular and Diving-Related Complications
- Pulmonary Hypertension Research and Treatments
- Mechanical Circulatory Support Devices
- Congenital heart defects research
- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- Eosinophilic Disorders and Syndromes
- Wireless Power Transfer Systems
- Fetal and Pediatric Neurological Disorders
- Atrial Fibrillation Management and Outcomes
- Selenium in Biological Systems
- Chemotherapy-induced cardiotoxicity and mitigation
- Atomic and Subatomic Physics Research
- Immunodeficiency and Autoimmune Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Patient-Provider Communication in Healthcare
Vanderbilt University Medical Center
2000-2024
Monroe Carell Jr. Children's Hospital
2007-2024
Vanderbilt University
1994-2023
Children's National
2014-2023
Children's Hospital & Medical Center
2023
University of Pennsylvania
2023
Texas Children's Hospital
2021
Baylor College of Medicine
2021
Boston Children's Hospital
2006-2015
University of Utah
2015
Heterozygous mutations in NKX2.5, a homeobox transcription factor, were reported to cause secundum atrial septal defects and result atrioventricular (AV) conduction block during postnatal life. To further characterize the role of NKX2.5 cardiac morphogenesis, we sought additional groups probands with anomalies first-degree AV block, idiopathic or tetralogy Fallot. We identified 7 novel by sequence analysis NKX2.5-coding region 26 individuals. Associated phenotypes included which was primary...
Ebstein anomaly and tricuspid valve dysplasia are rare congenital malformations associated with high perinatal mortality. The literature consists of small, single-center case series spanning several decades. We performed a multicenter study to assess the outcomes factors mortality after fetal diagnosis in current era.Fetuses diagnosed from 2005 2011 were included 23 centers. primary outcome was mortality, defined as demise or death before neonatal discharge. Of 243 fetuses at mean...
Prenatal detection (PND) has benefits for infants with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA), but associations between sociodemographic geographic factors PND have not been sufficiently explored. This study evaluated whether socioeconomic quartile (SEQ), public insurance, race ethnicity, rural residence, distance residence (distance driving time from a cardiac surgical center) are associated or timing PND, secondary aim to analyze differences...
OBJECT.: As more pediatric neurosurgeons become involved with fetal myelomeningocele closure efforts, examining refined techniques in the overall surgical approach that could maximize beneficial outcomes becomes critical. The authors compared for patients who had undergone a modified technique those repair as part of earlier Management Myelomeningocele Study (MOMS).Demographic and data were collected series 43 delivered utero at Fetal Center Vanderbilt from March 2011 through January 2013...
<h3>Importance</h3> Parents who receive a prenatal diagnosis of congenital heart disease may experience more short- and long-term stress than those postnatal diagnosis. To identify potential interventions to ameliorate that stress, the longitudinal emotional parents must first be understood. <h3>Objective</h3> better understand parents' accounts their own experience, particularly aspects they found stressful or challenging, strategies improve support. <h3>Design, Setting, Participants</h3>...
Selenium deficiency is common in patients with human immunodeficiency virus infection and may contribute to the development of cardiomyopathy. A 5‐year‐old boy congenital developed Evaluation for reversible causes cardiomyopathy was notable diagnosis selenium deficiency. Cardiac function improved on supplementation. The role cardiac dysfunction need nutritional evaluation supplementation malnourished acquired syndrome discussed. ( Journal Parenteral Enteral Nutrition 15: 347–349,1991)
Background In a recent multicenter study of perinatal outcome in fetuses with Ebstein anomaly or tricuspid valve dysplasia, we found that one third live-born patients died before hospital discharge. We sought to further describe postnatal management strategies and define risk factors for neonatal mortality circulatory at Methods Results This 23-center, retrospective from 2005 2011 included 243 dysplasia. Among patients, clinical echocardiographic were evaluated association palliated versus...
ace and ethnicity, socioeconomic status (SES), geography have been associated with differential outcomes in congenital heart disease death.In patients hypoplastic left syndrome (HLHS), lower SES has increased complications 1-year survival. 1o previous study examined how sociodemographics affect neonatal death among prenatally diagnosed HLHS.The goal was to investigate infants a prenatal diagnosis of HLHS understand associations between maternal patient characteristics hospital discharge...
A member of the Tennessee state legislature recently proposed a bill that would mandate all newborn infants to undergo pulse oximetry screening for purpose identifying those with critical structural heart disease before discharge home. The Task Force on Screening Newborn Infants Critical Congenital Heart Defects was convened September 29, 2005. This group reviewed current medical literature this topic, as well data obtained from Department Health, and debated merits potential detriments...
Background Tetralogy of Fallot with absent pulmonary valve is associated high mortality, but it remains difficult to predict outcomes prenatally. We aimed identify risk factors for mortality in a large multicenter cohort. Methods and Results Fetal echocardiograms clinical data from 19 centers over 10-year period were collected. Primary outcome measures included fetal demise overall mortality. Of 100 fetuses, pregnancy termination/postnatal nonintervention was elected 22. 78 intention treat,...
Families who receive a prenatal diagnosis of complex congenital heart disease (cCHD) often experience severe psychological distress and identify uncertainty as key source that distress. This study examined clinician-family conversations during initial fetal cardiology consultations to the topics discussed. In this observational, qualitative study, were audio-recorded, transcribed verbatim, coded by two independent coders. A codebook was inductively deductively developed applied. content...
An infant with a diagnosis of acute infantile cardiomyopathy was subsequently shown to have mucopolysaccharidosis VI. The mucopolysaccharidoses should be included in the differential cardiomyopathy.
Abstract Objective: To better understand parents’ accounts of their prenatal and postnatal experience after diagnosis CHD – particularly emotional processing coping mechanisms to identify strategies improve support. Methods: This single-centre, longitudinal qualitative study included pregnant mothers support persons seen in Fetal Cardiology Clinic at Vanderbilt Children’s Hospital from May through August 2019 for probable complex CHD. Twenty-seven individuals 17 families participated 62...
Collaborative multicenter research has significantly increased our understanding of fetal Ebstein anomaly, delineating risk factors for adverse outcomes as well predictors postnatal management. These data are incorporated into prenatal care and therapeutic strategies inform family counseling delivery planning to optimize care. This report details the translation findings from studies multidisciplinary a fetus with supraventricular tachycardia, circular shunt, including transplacental therapy...
The way clinicians communicate with parents during pregnancy about congenital heart disease (CHD) can significantly influence parental understanding of and psychological response to the diagnosis. A necessary first step improving communication used in fetal cardiology consultations is understand describe language currently used, which this paper aims do. Nineteen initial were audio-recorded, transcribed verbatim, coded by two independent coders. codebook was inductively developed applied all...