A5052653233- Electronic Health Records Systems
- Neonatal Respiratory Health Research
- Healthcare Systems and Technology
- Patient Safety and Medication Errors
- Telemedicine and Telehealth Implementation
- Cardiac Arrhythmias and Treatments
- Healthcare Operations and Scheduling Optimization
- Malaria Research and Control
- Healthcare Technology and Patient Monitoring
- Mobile Health and mHealth Applications
- Infant Nutrition and Health
- Infant Development and Preterm Care
- Neonatal and Maternal Infections
- Hospital Admissions and Outcomes
- Neuroscience of respiration and sleep
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Cardiovascular Conditions and Treatments
- Pharmaceutical studies and practices
- Interprofessional Education and Collaboration
- Parvovirus B19 Infection Studies
- Clinical Reasoning and Diagnostic Skills
- Clinical Laboratory Practices and Quality Control
- Calpain Protease Function and Regulation
- Pharmaceutical Practices and Patient Outcomes
Klinikum Braunschweig
2025
Vanderbilt University Medical Center
2017-2025
Monroe Carell Jr. Children's Hospital
2024
Hatch (Canada)
2024
Vanderbilt University
2014-2021
University of South Alabama
2013
Universitätsklinikum Gießen und Marburg
2013
Inserm
1982
<h3>Importance</h3> Infection in neonates remains a substantial problem. Advances for this population are hindered by the absence of consensus definition sepsis. In adults, Sequential Organ Failure Assessment (SOFA) operationalizes mortality risk with infection and defines The generalizability neonatal SOFA (nSOFA) late-onset infection-related unknown. <h3>Objective</h3> To determine nSOFA across multiple sites. <h3>Design, Setting, Participants</h3> A multicenter retrospective cohort study...
We describe the Clickbusters initiative implemented at Vanderbilt University Medical Center (VUMC), which was designed to improve safety and quality reduce burnout through optimization of clinical decision support (CDS) alerts.We developed a 10-step Clickbusting process program that included curriculum, CDS alert inventory, oversight process, gamification. carried out two 3-month rounds VUMC. completed descriptive analyses changes made alerts during firing rates before after program.Prior...
The characteristics of clinician activities while interacting with electronic health record (EHR) systems can influence the time spent in EHRs and workload. This study aims to characterize EHR as tasks define novel, data-driven metrics.We leveraged unsupervised learning approaches learn from sequences events audit logs. We developed metrics characterizing prevalence unique event repetition applied them categorize into 4 complexity profiles. Between these profiles, Mann-Whitney U tests were...
ABSTRACT Indomethacin is commonly used in the Neonatal Intensive Care Unit (NICU) for intraventricular hemorrhage (IVH) prophylaxis and patent ductus arteriosus (PDA) treatment, yet unpredictable clinical efficacy toxicity occur with standard weight‐based dosing. Model‐informed precision dosing (MIPD) produces individualized doses to overcome deficiencies of To identify an indomethacin therapeutic index MIPD target, exposure–response relationships (ERRs) were determined. pharmacokinetic...
Sepsis is a major cause of neonatal mortality and morbidity worldwide. A recent report suggested that murine host defense against infection could be compromised by immunosuppressive CD71(+) erythroid splenocytes. We examined the impact splenocytes on to endotoxin challenge or polymicrobial sepsis characterized circulating (CD235a(+)) cells in human neonates. Adoptive transfer an Ab-mediated reduction did not alter survival challenge. Ex vivo immunosuppression stimulated adult CD11b(+) was...
In extremely low birth weight (ELBW) infants, levels of hypercapnia (Paco 2) > 60 mm Hg are considered a risk factor for severe intraventricular hemorrhage (IVH). Since cerebral vasoreactivity depends on arterial pH (apH) rather than Paco 2, we hypothesize that the role mild-to-moderate (45-60 Hg) in occurrence IVH is modulated by metabolic component acid-base status. ELBW infants (n = 580, born < 28 wk gestation, and BW 1,000 g) were separated into "high-base deficit (BD)" 291) "low-BD"...
Collaborative multicenter research has significantly increased our understanding of fetal Ebstein anomaly, delineating risk factors for adverse outcomes as well predictors postnatal management. These data are incorporated into prenatal care and therapeutic strategies inform family counseling delivery planning to optimize care. This report details the translation findings from studies multidisciplinary a fetus with supraventricular tachycardia, circular shunt, including transplacental therapy...
Objective: This study explored the association between workload and level of burnout reported by clinicians in our neonatal intensive care unit (NICU). A qualitative analysis was used to identify specific factors that contributed modulated clinician NICU. Study Design: We conducted a utilizing postshift surveys explore 42 NICU advanced practice providers physicians over 6-month period. multinomial logistic regression models determine associations burnout. descriptive design with an inductive...
Abstract Background Management of neonatal parenteral protein intake for preterm infants is challenging and requires daily modifications the dose to account infant's postnatal age, birth weight, current volume concentration concurrent enteral nutrition. The objective this study was create evaluate Parenteral Protein Calculator (PPC), a clinical decision support system improve accuracy who require nutrition (PN). Materials Methods We integrated PPC into computerized provider order entry...
Health care organizations (HCOs) adopt strategies (eg. physical distancing) to protect clinicians and patients in intensive units (ICUs) during the COVID-19 pandemic. Many activities physically performed before pandemic have transitioned virtual systems These transitions can interfere with collaboration structures ICU, which may impact clinical outcomes. Understanding differences help HCOs identify challenges when transitioning setting post-COVID-19 era.This study aims leverage network...
Background Collaboration is vital within health care institutions, and it allows for the effective use of collective worker (HCW) expertise. Human-computer interactions involving electronic records (EHRs) have become pervasive act as an avenue quantifying these collaborations using statistical network analysis methods. Objective We aimed to measure HCW collaboration its characteristics by analyzing concurrent EHR usage. Methods By extracting usage events from audit log data, we defined...
Abstract Objective Acetaminophen and indomethacin are used for medical management of a patent ductus arteriosus. This study compared the efficacy these agents in ELBW infants. Study design was retrospective all courses acetaminophen. Baseline characteristics, details pharmacologic therapy, toxicity, acetaminophen serum concentrations were collected. The primary analysis rates closure with versus using Pearson’s Chi-squared test. Results Ductus after single course therapy similar between 16%...
A 1,612-g female born at 37 weeks’ gestation is noted to be small for gestational age and microcephalic. She was a 27-year-old gravida 1, para 0 white mother who has been on citalopram depression anxiety. Maternal prenatal tests show immunity rubella negative serology results hepatitis B surface antigen, syphilis, human immunodeficiency virus (HIV). First- second-trimester sonograms demonstrated normal fetal growth. However, performed during the third trimester showed intrauterine growth...