A5051947094- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Ultrasound and Hyperthermia Applications
- Psoriasis: Treatment and Pathogenesis
- Atomic and Subatomic Physics Research
- Advanced X-ray and CT Imaging
- Blood Pressure and Hypertension Studies
- Acute Ischemic Stroke Management
- MRI in cancer diagnosis
- Ovarian function and disorders
- Diversity and Career in Medicine
- Kawasaki Disease and Coronary Complications
- Cardiovascular Syncope and Autonomic Disorders
- Reproductive Biology and Fertility
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Structural Anomalies and Repair
- Peripheral Artery Disease Management
- Biomarkers in Disease Mechanisms
- Hospital Admissions and Outcomes
- Opioid Use Disorder Treatment
- Pharmaceutical industry and healthcare
United Lincolnshire Hospitals NHS Trust
2024
Northumbria Healthcare NHS Foundation Trust
2024
Freeman Hospital
2024
Newcastle University
2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2024
Ulverscroft (United Kingdom)
2024
NIHR Clinical Research Network
2024
Cooper University Health Care
2024
Cooper Medical School of Rowan University
2024
University Hospitals of Leicester NHS Trust
2017-2022
In patients with stable angina, two strategies are often used to guide revascularization: one involves myocardial-perfusion cardiovascular magnetic resonance imaging (MRI), and the other invasive angiography measurement of fractional flow reserve (FFR). Whether a MRI-based strategy is noninferior an FFR-based respect major adverse cardiac events has not been established.We performed unblinded, multicenter, clinical-effectiveness trial by randomly assigning 918 typical angina either or more...
BackgroundWhether a conservative strategy of medical therapy alone or plus invasive treatment is more beneficial in older adults with non–ST-segment elevation myocardial infarction (NSTEMI) remains unclear.MethodsWe conducted prospective, multicenter, randomized trial involving patients 75 years age NSTEMI at 48 sites the United Kingdom. The were assigned 1:1 ratio to best available an coronary angiography and revascularization therapy. Patients who frail had high burden coexisting...
In patients with stable coronary artery disease (CAD), decisions regarding revascularisation are primarily driven by the severity and extent of luminal stenoses as determined invasive angiography. More recently, based on fractional flow reserve (FFR) have shown improved event free survival. Cardiovascular magnetic resonance (CMR) perfusion imaging has been to be non-inferior nuclear in a multi-centre setting superior single centre trial. addition, it is similar invasively FFR therefore...
BackgroundAmblyopia, the most common visual impairment of childhood, is a public health concern. An extended period optical treatment before patching recommended by clinical guidelines several countries. The aim this study was to compare an intensive regimen, with and without (EOT), in randomised controlled trial.MethodsEuPatch trial conducted 30 hospitals UK, Greece, Austria, Germany, Switzerland. Children aged 3–8 years newly detected, untreated amblyopia (defined as interocular difference...
Ovarian hyperstimulation syndrome (OHSS) can be a severe and potentially life-threatening complication of ovarian stimulation for IVF. Coasting or withholding gonadotrophin relies on frequent estimation serum oestradiol to identify patients at risk. A modified coasting protocol was developed in which identification risk OHSS based ultrasound monitoring. Serum concentrations were measured only with >20 follicles (high risk). If <3000 pmol/l, the dose maintained; if >/=3000 pmol/l but <13200...
To determine whether quantitative wall motion assessment by CMR myocardial feature tracking (CMR-FT) would reduce the impact of observer experience as compared to visual analysis in patients with ischemic cardiomyopathy (ICM).15 consecutive ICM referred for hibernating myocardium were studied at 3 Tesla using SSFP cine images rest and during low dose dobutamine stress (5 10 μg/kg/min dobutamine). Conventional visual, qualitative was performed independently blinded an experienced...
AimsTo assess the feasibility of high-resolution quantitative cardiovascular magnetic resonance (CMR) voxel-wise perfusion imaging using clinical 1.5 and 3 T sequences to validate it fluorescently labelled microspheres in combination with a state art cryomicrotome novel, isolated blood-perfused MR-compatible free beating pig heart model without respiratory motion.
<sec> <title>BACKGROUND</title> Transcatheter aortic valve implantation (TAVI) has become a potential treatment modality for symptomatic patients with severe stenosis (AS) across all surgical risk profiles. However, peri-procedural stroke remains persistent and serious complication significant implications patient outcomes healthcare systems. Reported incidence ranges between 2-7%. As the benefit of cerebral protection devices optimal antithrombotic regime following TAVI remain unclear,...
Technical advances in perfusion cardiovascular magnetic resonance (CMR), particularly accelerated data acquisition methods, allow myocardial imaging with unprecedented spatial resolution. However, it is not clear how implementation of these recent affects image quality, signal and contrast to noise ratios (SNR & CNR) the occurrence important artefacts routine clinical imaging. The objective this study was therefore compare a standard an advanced, high-resolution sequence. A ultrafast...
Perfusion cardiovascular magnetic resonance (CMR) and fractional flow reserve (FFR) are emerging as the most accurate tools for assessment of myocardial ischemia noninvasively or in catheter laboratory. However, there is limited data comparing CMR FFR patients with multi-vessel disease. This study aims to evaluate correlation between detected by multivessel coronary disease at angiography. Forty-one (123 vascular territories) angiographic 2- 3-vessel artery (visual stenosis >50 %) underwent...
Controlled ovarian stimulation for IVF and embryo transfer outcome parameters were compared retrospectively in 31 women with clomiphene-resistant polycystic syndrome (PCOS). Of these women, 15 had previously undergone laparoscopic diathermy before (group A, total 22 cycles) 16 not surgical treatment B, 24 cycles). No statistically significant differences observed the number of oocytes retrieved, although embryos available was significantly higher group B (7.1 +/- 3.8 versus 4.6 2.7, P <...
Background Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a promising novel method for quantification of wall mechanics from standard steady-state free precession (SSFP) images. We sought to determine whether field strength affects the intra-observer reproducibility CMR-FT strain analysis. Methods studied 2 groups, each consisting 10 healthy subjects, at 1.5 or 3 Tesla. Analysis was performed baseline and after 4 weeks using dedicated prototype software (Tomtec,...
ObjectiveTo describe a novel hardware MR-perfusion phantom to model first-pass of bolus contrast in the cardiac cavities and large thoracic vessels (arterial input function, AIF) myocardium, allowing for acquisition dynamic data precise control output myocardial perfusion true validation quantification.
Background Coronary angiography and the extent of coronary luminal stenosis has historically been main factor used in guiding decisions regarding revascularisation patients with stable artery disease. More recently, based on invasive fractional flow reserve (FFR) measurements shown to result a significant benefit for event free survival. Cardiac magnetic resonance (CMR) perfusion imaging be superior nuclear potential become non-invasive test choice. Methods The MR-INFORM study is...
There are limited data around sex differences in the risk profile, treatments and outcomes of percutaneous coronary intervention (PCI) chronic total occlusion (CTO) lesions contemporary interventional practice. We investigated impact on clinical procedural characteristics, complications a national cohort.We created longitudinal cohort (2006-2018, n = 30,605) patients with stable angina who underwent CTO PCI British Cardiovascular Intervention Society (BCIS) database. Clinical, demographic,...