A5100449925- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Plant Virus Research Studies
- Nanoparticle-Based Drug Delivery
- CRISPR and Genetic Engineering
- Adenosine and Purinergic Signaling
- Liver Disease Diagnosis and Treatment
- Platelet Disorders and Treatments
- Biomarkers in Disease Mechanisms
- Alzheimer's disease research and treatments
- Gout, Hyperuricemia, Uric Acid
- Ferroptosis and cancer prognosis
- Congenital Heart Disease Studies
- Adrenal and Paraganglionic Tumors
- Coronary Artery Anomalies
- Intracerebral and Subarachnoid Hemorrhage Research
- Animal Disease Management and Epidemiology
- Zeolite Catalysis and Synthesis
- Cancer, Hypoxia, and Metabolism
- Respiratory viral infections research
- Advanced Drug Delivery Systems
Union Hospital
2025
Huazhong University of Science and Technology
2024-2025
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2024
Union Hospital
2024
Zhejiang University
2023-2024
University of Science and Technology of China
2016-2023
North Sichuan Medical University
2022
Peking University People's Hospital
2022
Peking University
2022
First Affiliated Hospital of Zhengzhou University
2022
A gas-phase reaction network involving reactive intermediates such as alkyl and peroxide radicals hydroperoxides have long remained a mystery in oxidative coupling of methane (OCM) dehydrogenation ethane (ODHE) reactions. Herein we report direct observations including CH2, CH3•, C2H5•, CH3OO•, C2H5OO•, CH3OOH, C2H5OOH during OCM ODHE reactions over Li/MgO catalysts with an online synchrotron VUV photoionization mass spectrometer connected to catalytic reactor adjustable distances between the...
Although inflammation has been proposed to be a candidate risk factor for cerebral small vessel disease (CSVD), previous findings remain largely inconclusive and vary according status study designs. The present aimed investigate possible associations between inflammatory biomarkers MRI markers of CSVD.A group 15 serum representing variety those putatively involved in the cascade was grouped assessed cross-sectional involving 960 stroke-free subjects. biomarker panel as follows: systemic...
Purpose: Type II diabetes mellitus (T2DM) has been found to increase the mortality of patients with hepatocellular carcinoma (HCC).Therefore, this study aimed establish and validate a machine learning-based explainable prediction model prognosis in HCC T2DM undergoing transarterial chemoembolization (TACE).Patients Methods: The was developed using data from derivation cohort comprising three medical centers, followed by external validation utilizing patient extracted another center.Further,...
Patients with type 2 diabetes mellitus (T2DM) are at a high risk of cognitive impairment, insulin resistance playing pivotal role. β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is considered predictor Alzheimer's disease. However, the potential roles BACE1 in and impairment T2DM remain unclear.We measured plasma levels, cleavage activities for Swedish mutant (APPsw) receptor β subunit (INSR-β), soluble INSR (sINSR) levels clinical cohort study.T2DM patients or without exhibited...
ABSTRACT Activation of inflammasomes—immune system receptor sensor complexes that selectively activate inflammatory responses—has been associated with diverse human diseases, and many nanomedicine studies have reported structurally chemically inorganic nanomaterials cause excessive inflammasome activation. Here, in stark contrast to reports other nanomaterials, we find nickel-cobalt alloy magnetic nanocrystals (NiCo NCs) actually inhibit activation NLRP3, NLRC4 AIM2 inflammasomes. We show...
Abstract Transcription factor EB (TFEB) is a master regulator of autophagy and lysosomal biogenesis. Here, silver nanoparticles (Ag NPs)‐induced cytoprotective required TFEB shown. Ag NPs‐induced nucleus translocation through well‐established mechanism involving dephosphorylation at serine‐142 serine‐211 but independent both the mTORC1 ERK1/2 pathways. precedes induced by NPs leads to enhanced expression autophagy‐essential genes. Knocking down attenuates induction demonstrated, in meantime,...
The possible adverse effects of engineered nanomaterials on human health raise increasing concern as our research nanosafety intensifies. Upon entry into a body, whether intended for theranostic purpose or through unintended exposure, tend to accumulate in the liver, leading hepatic damage. A variety nanoparticles, including rare earth upconversion nanoparticles (UCNs), have been reported elicit hepatotoxicity, most cases inducing immune response activating reactive oxygen species. Many...
Activation of the nod-like receptor protein 3 (NLRP3) inflammasome by monosodium urate (MSU) crystals has been identified as molecular basis for acute inflammatory response in gouty arthritis. However, MSU alone are not sufficient to induce arthritis (AGA). Adenosine triphosphate (ATP) is an endogenous signaling molecule involved NLRP3 activation. We aimed explore role ATP crystal-induced AGA development. In peripheral blood mononuclear cell-derived macrophages obtained from gout patients,...
The diverse biological effects of nanomaterials form the basis for their applications in biomedicine but also cause safety issues. Induction autophagy is a cellular response after nanoparticles exposure. It may be beneficial some circumstances, yet autophagy‐mediated toxicity raises an alarming concern. Previously, it has been reported that upconversion (UCNs) elicit liver damage, with contributing most this toxicity. However, detailed mechanism unclear. This study reveals persistent...
Abstract Recombinant human thrombopoietin (rHuTPO) is a drug that used clinically to promote megakaryocyte and platelet generation. Here, we report the mitigative effect of rHuTPO (administered after exposure) against severe whole body irradiation in mice. Injection for 14 consecutive days following exposure significantly improved survival rate lethally irradiated RHuTPO treatment notably increased bone marrow cell density LSK numbers mice sub-lethal primarily by promoting residual HSC...
Short-term spinal cord stimulation (st-SCS) has been widely used to treat herpetic-related neuralgia (HN) in China for several years, but is still heavily debated as it no strong evidence clinical application. Therefore, a questionnaire survey among the Chinese pain specialist workgroup of Neuromodulation Society and Medical Doctor Association was carried out achieve consensus about use st-SCS HN treatment.The contents include basic information doctors (hospital level, work experience,...
DM with positive anti-melanoma differentiation-related gene 5 (MDA5) antibody is an autoimmune disease multiple complications. Interstitial lung diseases (ILDs) are significantly associated and particularly related to MDA5+ DM. This article aims explore potential molecular mechanisms develop new diagnostic biomarkers for DM-ILD.The series matrix files of non-specific interstitial pneumonia (NSIP) were downloaded from the Gene Expression Omnibus (GEO) database identify differentially...
Hemipteran insects transmit viruses when infesting plants, during which vectors activate salicylic acid (SA)-regulated antiviral defenses. How vector-borne plant circumvent these defenses is largely unexplored. During co-infections of begomoviruses and betasatellites in betasatellite-encoded βC1 proteins interfere with SA signaling reduce the activation resistance. inhibits SA-induced degradation NbNPR3 (Nicotiana benthamiana nonexpressor pathogenesis-related genes 3), a negative regulator...
The pharmacokinetics of terbinafine was studied in six healthy fasted cats following a single intravenous and oral administration at dose 10 mg/kg 30 mg/kg, respectively, according to two-period crossover design. Plasma concentrations were determined using reverse phase liquid chromatographic method. pharmacokinetic parameters calculated by non-compartmental analysis with WinNonlin 5.2.1 software. After administration, the terminal half-life area under curve from time 0 infinity 10.40 ± 4.56...
Several studies have suggested that caffeic acid phenethyl ester (CAPE) can induce the expression of hypoxia inducible factor-1α (HIF-1α) protein. We determined whether CAPE has a novel function in improving homing and engraftment haematopoietic stem/progenitor cells (HSPCs) by regulating HIF-1α gene bone marrow (BM) niche.For survival experiments, lethally irradiated C57BL/6 mice were injected with low number BM mononuclear (MNCs) according to indicated schedule. Homing efficiency analysis...
NLRP3 inflammasome activation is a central process in initiating gout flares. The unique conformational rearrangement of the P2X7 receptor (P2X7R) upon ATP binding critical for inflammasome. However, studies on allosteric modulation P2X7R treatment are limited. Here, we aimed to investigate therapeutic implications targeting by designing inhibitor and validating inhibitory function activation. Through virtual screening, identified Z1456467176 (N-{3-[(2-aminoethyl) sulfamoyl]...
<b><i>Purpose:</i></b> To assess whether parameters on preprocedural CT can be utilized to predict the response of NETLM transcatheter arterial bland embolization (TAE). <b><i>Methods:</i></b> We retrospectively reviewed 135 target lesions from 48 patients who underwent TAE and with complete multiphasic CT. Parameters including longest diameter, mean attenuation value in nonenhanced, arterial, portal-venous phases were collected each lesion....
Hepatitis B virus (HBV) reactivation (HBVr) is a major concern for hepatocellular carcinoma (HCC) patients undergoing hepatic arterial infusion chemotherapy (HAIC) using mFOLFOX6 regimen. There insufficient evidence to support the routine use of HAIC combined with immunotherapy in HCC HBVr. The aim this study was examine adverse events (AEs) related HBVr after HAIC, or without immunotherapy, and assess effectiveness antiviral prophylaxis
Abstract We reported a novel function of recombinant human thrombopoietin (TPO) in increasing hematopoietic stem and progenitor cell (HSPC) homing to the bone marrow (BM). Single doses TPO treatment recipients immediately after BM transplantation showed significantly improved HSPCs BM, which subsequently resulted enhanced short- long-term engraftment mice. found that could downregulate expression secretion matrix metalloproteinase 9 cells. As result, SDF-1α level was increased niche....
Sensitive detection of adenosine and deoxyadenosine isomers in food.
Endothelin-converting enzyme-1 (ECE1) plays a key role in the development of subset neural crest lineages such as cardiogenesis. Genetic variants ECE1 C338A (rs213045) and T839G (rs213046) have been shown to alter expression. This observation led us hypothesize that two polymorphisms might influence susceptibility sporadic congenital heart disease (CHD). We conducted case-control study comprised 945 CHD cases 972 non-CHD controls Chinese population. tested our hypothesis by genotyping...
<b><i>Background:</i></b> Although inflammation is found to be related arteriopathy pathogenesis, it yet determined the distinct correlations of specific inflammatory biomarker types contributing different cerebral large vessel diseases. We aimed investigate association between multiple biomarkers and atherosclerosis dolichoectasia in a community-based sample. <b><i>Methods:</i></b> A total 960 participants Shunyi study were included. panel 14...