A5100333544- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Multiple Myeloma Research and Treatments
- Renal cell carcinoma treatment
- Long-Term Effects of COVID-19
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Liver physiology and pathology
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Bone health and treatments
- Ovarian cancer diagnosis and treatment
- Signaling Pathways in Disease
Union Hospital
2014-2025
Huazhong University of Science and Technology
2015-2025
Hubei Provincial Center for Disease Control and Prevention
2025
Weatherford College
2024
Union Hospital
2011-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2019-2024
Chengdu Medical College
2024
Eastern Hepatobiliary Surgery Hospital
2023
Second Military Medical University
2023
Ministry of Education of the People's Republic of China
2023
Abstract Background The 2019 novel coronavirus has caused the outbreak of acute respiratory disease in Wuhan, Hubei Province China since December 2019. This study was performed to analyze clinical characteristics patients who succumbed and recovered from (COVID-19). Methods Clinical data were collected two tertiary hospitals Wuhan. A retrospective investigation conducted fatal cases COVID-19 (death group) we compare them with (recovered group). Continuous variables analyzed using...
The role of interleukin (IL)-6 in the pathogenesis cardiac myocyte hypertrophy remains controversial.To conclusively determine whether IL-6 signaling is essential for development pressure overload-induced left ventricular (LV) and to elucidate underlying molecular pathways.Wild-type knockout (IL-6(-/-)) mice underwent sham surgery or transverse aortic constriction (TAC) induce overload. Serial echocardiograms terminal hemodynamic studies revealed attenuated LV superior preservation function...
Deregulated microRNAs (miRNAs) and their roles in cancer development have attracted much attention. Two miRNAs, miR-15a miR-16, which act as putative tumor suppressor by targeting the oncogene BCL2 , been implicated cell cycle, apoptosis proliferation. In this study, we investigated possible role of miR-15a/16 angiogenesis multiple myeloma (MM). Using a stem-loop quantitative reverse transcription–PCR, analyzed expressions bone marrow samples from newly diagnosed MM patients panel lines....
BCMA-specific chimeric antigen receptor-T cells (CAR-Ts) have exhibited remarkable efficacy in refractory or relapsed multiple myeloma (RRMM); however, primary resistance and relapse exist with single-target immunotherapy. Bispecific CARs are proposed to mitigate these limitations.We constructed a humanized bispecific BM38 CAR targeting BCMA CD38 tested the antimyeloma activity of CAR-Ts vitro vivo. Twenty-three patients RRMM received infusions phase I trial.BM38 showed stronger cytotoxicity...
Objectives: An ongoing outbreak of coronavirus disease 2019 is spreading globally. Acute hypoxemic respiratory failure the most common complication 2019. However, clinical effectiveness early high-flow nasal oxygen treatment in patients with acute has not been explored. This study aimed to analyze and identify variables predicting failure. Design: A multicenter, retrospective cohort study. Setting: Three tertiary hospitals Wuhan, China. Patients: Forty-three confirmed adult treated oxygen....
Background This study aimed to evaluate the longitudinal progression of residual lung abnormalities (ground-glass opacities, reticulation and fibrotic-like changes) pulmonary function at 3 years following coronavirus disease 2019 (COVID-19). Methods prospective, cohort enrolled COVID-19 survivors who exhibited upon discharge from two hospitals. Follow-up assessments were conducted 6 months, 12 2 post-discharge, included tests, 6-min walk distance (6MWD), chest computed tomography (CT) scans...
Abstract Pyroptosis is a form of programmed cell death (PCD) that plays vital role in immunity and diseases. Although it was recently reported chemotherapy drugs can induce pyroptosis through caspase‐3‐dependent cleavage gasdermin E (GSDME), the osteosarcoma (OS) with dioscin less understood. In this study, we explored effects on OS vitro vivo further elucidated underlying molecular mechanisms found dioscin‐triggered GSDME‐dependent GSDME‐N generated by caspase‐3. Furthermore, inhibited...
Chromosome 17p deletions are present in 10% of patients with newly diagnosed multiple myeloma (MM), and associated inferior prognosis. miR‐324‐5p is located on chromosome 17p, shows diverse functions different types cancers. However, its role MM largely unknown. Here we found the expression was decreased MM, especially del(17p) MM. In contrast, hedgehog (Hh) signaling components elevated, indicating a correlation between Hh important for pathogenesis maintenance stem cell compartment....
Inherent or acquired resistance to chemotherapeutic drugs is still an obstacle for the treatment of multiple myeloma (MM). MicroRNA dysregulation related development chemoresistance in cancers. However, its role MM largely unknown. Here we demonstrated that miR-221/222 were upregulated plasma cells from patients with MM, especially those relapsed refractory disease. Moreover, expression levels inversely correlated dexamethasone (Dex) sensitivity human cell lines. Importantly, found Dex...
N6-methyladenosine (m6A), as the most pervasive internal modification of eukaryotic mRNA, plays a crucial role in various cancers, but its multiple myeloma (MM) pathogenesis has not yet been investigated. In this study, we revealed significantly decreased m6A methylation plasma cells (PCs) from MM patients and showed that abnormal level resulted mainly upregulation demethylase fat mass obesity-associated protein (FTO). Gain- loss-of-function studies demonstrated FTO tumor-promoting...
To evaluate the efficacy and safety of transarterial chemoembolization (TACE) combined with camrelizumab (hereafter, TACE-camrelizumab) in treatment patients recurrent hepatocellular carcinoma (R-HCC) after curative resection.R-HCC who underwent TACE plus or TACE-alone from January 2016 to August 2021 were retrospectively evaluated. Patients assessed for tumor response, progression-free survival, survival rates adverse events.Seventy-one included this study, including 20 TACE- group 51...
Objectives To compare the safety and efficacy of lenvatinib (LEN) combined with camrelizumab plus transcatheter arterial chemoembolization (TACE-LEN-C) TACE LEN (TACE-LEN) in patients unresectable hepatocellular carcinoma (uHCC). Methods Eighty-three uHCC treated TACE-LEN-C or TACE-LEN from September 2018 to May 2021 were enrolled this retrospective study. Overall survival (OS), progression-free (PFS), local tumor response, adverse events (AEs) evaluated. Univariate multivariate analyses...
Abstract Background The prognostic significance of the CRAFITY score ( CR P and AF in I mmuno T herap Y ) has been demonstrated hepatocellular carcinoma (HCC) patients receiving immunotherapy. purpose this study was to investigate utility predictive value HCC after transarterial chemoembolization (TACE) combination with tyrosine kinase inhibitors (TKIs) Materials methods Data from advanced treated TACE plus TKIs PD-1 inhibitor January 2019 June 2022 were collected analyzed retrospectively....
Browning white adipocytes may be a new target in anti-obesity therapy. Pentamethylquercetin (PMQ) has been shown to have effects monosodium glutamate-induced obese mice. Here, we aimed study the of PMQ vitro and vivo determine if adipose browning is involved mechanism underlying PMQ. We evaluated on cell proliferation, differentiation, glucose consumption, cellular lipid metabolism, related brown gene expression 3T3-L1 adipocytes. also investigated mouse model high-fat diet (HFD)-induced...
Objective This study was designed to determine whether a transjugular intrahepatic portosystemic shunt (TIPS) combined with embolotherapy superior TIPS alone. Methods Seventy-nine patients were included in the (43 and group 36 alone group). Embolotherapy performed after using coils tissue adhesive agent. The pressure gradient (PPG) lower than 12 mm Hg all patients. Multivariate analyses Cox regression model, probabilities of survival rebleeding estimated Kaplan-Meier method. Results Baseline...
4507 Background: Chinese patients (pts) account for more than 50% of hepatocellular carcinoma (HCC) cases in the world and have special features etiology, biological behavior, treatment strategy prognosis. The aim this study was to evaluate efficacy safety apatinib, an inhibitor targeting vascular endothelial growth factor receptor-2, pts with pretreated advanced HCC. Methods: In randomized, placebo-controlled, double-blind, phase 3 trial done 31 sites China, HCC who had received at least...
To evaluate the efficacy and safety of transarterial chemoembolization (TACE) combined with tyrosine kinase inhibitors (TKIs: sorafenib, lenvatinib, apatinib) plus camrelizumab (TACE-TKIs-C) vs TACE TKIs (TACE-TKIs) for advanced hepatocellular carcinoma (HCC).In this two-center retrospective study, patients HCC treated TACE-TKIs-C or TACE-TKIs were enrolled between January 1, 2018, to October 2020. A total 260 eligible received (N=70) (N=190). The differences in overall survival (OS),...
Purpose: Type II diabetes mellitus (T2DM) has been found to increase the mortality of patients with hepatocellular carcinoma (HCC).Therefore, this study aimed establish and validate a machine learning-based explainable prediction model prognosis in HCC T2DM undergoing transarterial chemoembolization (TACE).Patients Methods: The was developed using data from derivation cohort comprising three medical centers, followed by external validation utilizing patient extracted another center.Further,...
AIM:To compare the outcomes of laparoscopic and open splenectomy azygoportal devascularization for portal hypertension. METHODS:From June 2006 to March 2009, disconnection (LSD) were performed on 28 patients with cirrhosis, bleeding due hypertension, secondary hypersplenism.Success was achieved in 26 patients.Demographic, intraoperative, postoperative variables compared.RESULTS: Success all but two (7.14%) who required (OSD).The operation time significantly longer undergoing LSD than those...
Adiponectin is an adipocyte-derived hormone that plays a pivotal role in the regulation of lipid and glucose metabolism. Up-regulation adiponectin expression production has been shown to benefit for metabolic disorders, including type 2 diabetes, hyperlipidemia, etc. The present study investigated whether novel polymethoxylated flavonoid pentamethylquercetin (PMQ), member flavonoids family which seabuckthorn (Hippophae L.) would affect differentiated 3T3-L1 adipocytes. It was found PMQ...