A5102825968- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Wave and Wind Energy Systems
- Cancer Mechanisms and Therapy
- Histiocytic Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Pharmacological Effects of Natural Compounds
- Neurological Disease Mechanisms and Treatments
- Multiple and Secondary Primary Cancers
- Cardiac Ischemia and Reperfusion
- Metastasis and carcinoma case studies
- Traditional Chinese Medicine Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Pediatric Hepatobiliary Diseases and Treatments
- Ocean Waves and Remote Sensing
- Gastric Cancer Management and Outcomes
- Coastal and Marine Dynamics
- Cancer Research and Treatments
- Barrier Structure and Function Studies
- Gallbladder and Bile Duct Disorders
Anhui Provincial Hospital
2024
Beijing Chaoyang Emergency Medical Center
2023
Capital Medical University
2023
Yahoo (United Kingdom)
2023
National Centre for the Performing Arts
2023
Sun Yat-sen University
2002-2022
Sun Yat-sen University Cancer Center
2002-2022
Heilongjiang Institute of Technology
2018-2021
Kennedy Krieger Institute
2021
Johns Hopkins Medicine
2021
This is an Accepted Manuscript, which has been through the RSC Publishing peer review process and accepted for publication. manuscripts are published online shortly after acceptance. version of article will be replaced by fully edited, formatted proof read Advance Article as soon this available.
4046 Background: Adding a claudin18.2 antibody to chemotherapy is clinically validated approach for patients with high CLDN18.2 expressing tumors. TST001 best in class differentiated whose improved affinity and enhanced antibody-dependent cellular cytotoxicity, leads anti-tumor activity low medium expressors gastric cancer cells. Pre-clinical studies also showed that has stronger tumor regression effects than the IMAB362-analog at same dose. Methods: The efficacy safety of osemitamab CAPOX...
4507 Background: Chinese patients (pts) account for more than 50% of hepatocellular carcinoma (HCC) cases in the world and have special features etiology, biological behavior, treatment strategy prognosis. The aim this study was to evaluate efficacy safety apatinib, an inhibitor targeting vascular endothelial growth factor receptor-2, pts with pretreated advanced HCC. Methods: In randomized, placebo-controlled, double-blind, phase 3 trial done 31 sites China, HCC who had received at least...
There is increasing evidence suggesting that the establishment of Pim-3 involved in tumorigenesis. This study aimed to investigate expression and clinicopathological significance colorectal cancer (CRC). Clinical pathology data were collected from 410 CRC patients who received radical resection pathologically confirmed at Sun Yat-Sen University Cancer Center between October 2002 December 2008. We compared primary focus liver metastasis investigated correlations with other...
Abstract Purpose To explore the relationships between episcleral hemangioma distribution patterns and trabeculotomy prognosis in young Sturge–Weber syndrome (SWS) patients. Methods syndrome‐induced glaucoma patients less than 4 years of age who underwent our Ophthalmology Department from February 2016 to June 2017 were included. Every patient could be divided into simple vascular abnormal network (SEVAN) or multiple (MEVAN) groups according their patterns. The intraocular pressure (IOP) was...
We investigated possible links between the etiology of liver disease and gallstone risk in Chinese patients with chronic (CLD). compared outcomes 267 CLD gallstones those a control group 1,015 without gallstones. Logistic regression analyses adjusting for demographic features other factors revealed that cirrhosis increased development twofold [adjusted odds ratio (AOR); 95% confidence interval (95% CI): 2.343 (1.710-3.211)]. HCV infection 1-2-fold [AOR; CI: 1.582 (1.066-2.347)] higher than...
We investigated the possible link between liver cirrhosis and gallstone risk in chronic hepatitis C (CHC) patients China. To analyze association development, we compared outcomes of 133 Chinese CHC with gallstones an age-, sex-, virus RNA level-matched control group 431 without gallstones. found that was more prevalent (40.6%) than (24.4%). Logistic regression analyses adjusting for demographic features other factors revealed increased development 2-fold (adjusted odds ratio [AOR]: 2.122;...
4076 Background: C+A combination therapy displayed high objective response rate, disease control and durable with a manageable safety profile in patients (pts) advanced HCC. Here we performed an updated analysis of OS to characterize the benefit HCC pts. Methods: 70 pts first-line cohort 120 second-line were enrolled. Median 2-year rate evaluated via data (data cutoff, 3 January, 2021). time from enrollment cutoff total population (N = 190) was 29.1 months (range, 24.0-33.7). Results: events...
e16602 Background: Outcomes remain poor for patients with advanced hepatocellular carcinoma (HCC). Hepatic arterial infusion chemotherapy (HAIC), antiangiogenic agents, and immune checkpoint inhibitors (ICIs) are available monotherapy options. Considering different anti-malignancy mechanisms, combining these three modalities may improve outcomes. We aimed to assess the efficacy safety in a small cohort treated HAIC combined Apatinib ICI (Toripalimab) HCC patients. Methods: performed...
We investigated associations between inflammatory marker levels and hepatitis C virus (HCV)-related compensated liver cirrhosis risk in patients with chronic (CHC) infection China. used a case-control design data from the records of 110 Chinese CHC for study; 458 who did not have diagnosis were matched to case group by age sex characteristics. also fatty disease factors. The had lower platelet-to-lymphocyte ratio (PLR) values (60.63 [44.09, 89.31]) compared control (80.24 [57.85, 111.08])....
Objective This study was performed to clarify the influence of nonalcoholic fatty liver disease (NAFLD) on stiffness measurement (LSM) and establish a new diagnostic model. Methods A retrospective cohort 601 patients with chronic hepatitis B (CHB) enrolled as derivation group, prospective 30 concurrent CHB NAFLD validation group. Results The area under receiver operating characteristic curve LSM in without (0.792) higher than that (0.720) diagnosing significant fibrosis. Patients had...
527 Background: Microvascular invasion (MVI) is a risk factor for recurrence after hepatectomy hepatocellular carcinoma (HCC) patients. This study aimed to investigate efficacy and safety of postoperative adjuvant transarterial infusion chemotherapy (TAI) with FOLFOX regimen HCC patients MVI. Methods: In this prospective, phase III, randomized, open-labeled, controlled clinical trial, histologically confirmed MVI were randomly assigned (1:1) receive either 1-2 cycles TAI (AT group) or...
Abstract Background To evaluate the choroidal changes in Sturge-Weber syndrome (SWS) secondary glaucoma and non-glaucoma port-wine stain (PWS) patients by enhanced depth imaging optical coherence tomography (EDI-OCT). Methods SWS PWS who were over 3 years old treated or screened at our ophthalmology department included study. Baseline demographics, EDI-OCT fundus photography data collected from all patients. Results Overall, 46 (NGPWS) 35 (SG) included, with mean ages of 16.52 ± 13.63 13.94...
346 Background: This study aimed to understand patient decision-making factors for post-operative adjuvant treatment after resection of hepatocellular carcinoma (HCC) in China. Methods: Patients who had received surgical HCC the last 2 years at 27 hospitals China were surveyed using a questionnaire (https://pro.wenjuan.com/t/jUZFU). Feedback was collected by telephone or online. The survey covered three domains: decision making, selection regimen and influence recurrence risk on willingness...
<title>Abstract</title> Relapse is a major cause of death after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia (AML). Treatment options patients who relapse are very limited. Programmed (PD)-1 blockade has shown therapeutic activity in selected hematologic malignancies, but would trigger severe graft-<italic>versus</italic>-host disease (GvHD), which obstacle to its success. Herein, we reported the results sequential PD-1 therapy with relapsed AML umbilical...
Abstract Clone 14G11 is a mouse anti-Claudin 18.2 monoclonal antibody developed by Transcenta. The was generated against linear epitope located on the extracellular domain of loop1 and has binding site that overlaps with therapeutic Osemitamab. It selected to further develop for detection Claudin expression in human cancer. Agilent Technologies, Inc. developing IHC pharmDx as an immunohistochemical (IHC) assay protein gastric gastroesophageal junction (GEJ) adenocarcinoma support clinical...
5532 Background: To evaluate the safety and efficacy of nimotuzumab plus concurrent intensity-modulated radiation therapy (IMRT) chemotherapy for treatment locally advanced cervical squamous cell cancer (LACSCC). Methods: From December 2013 to March 2017, 31 patients with stage (FIGO 2009) IB2-IVA were enrolled in this single-arm clinical trial at an academic medical center received chemoradiotherapy nimotuzumab. All underwent least 1 year follow-up. The prescription dose was 50.4 Gy/28 F on...
Abstract Background Both stereotactic body radiotherapy (SBRT) and radiofrequency ablation (RFA) are effective local treatments for hepatocellular carcinoma (HCC), but whether RFA is superior to SBRT still controversial. Therefore, we performed a meta-analysis compare the treatment outcomes of with as curable or bridge intention.Methods We searched online databases studies that compared outcome RFA. Eligibility criteria included evaluation control, overall survival (OS), transplant rate,...