A5014559643- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- COVID-19 Clinical Research Studies
- Vascular Malformations and Hemangiomas
- MicroRNA in disease regulation
- Tumors and Oncological Cases
- Endoplasmic Reticulum Stress and Disease
- Histiocytic Disorders and Treatments
- RNA modifications and cancer
- Anesthesia and Neurotoxicity Research
- Viral Infections and Immunology Research
- Long-Term Effects of COVID-19
- Congenital heart defects research
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Clinical Nutrition and Gastroenterology
- Ocular Oncology and Treatments
- Ion Transport and Channel Regulation
- Developmental Biology and Gene Regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Gut microbiota and health
- Venous Thromboembolism Diagnosis and Management
- Nutrition and Health in Aging
- Calpain Protease Function and Regulation
First Hospital of Jilin University
2016-2025
Jilin University
2016-2025
Guangzhou Medical University
2021-2024
Guangzhou Women and Children Medical Center
2021-2024
Shanghai Ninth People's Hospital
2020-2024
Shanghai Jiao Tong University
2016-2024
University of California, Riverside
2024
Songjiang District Central Hospital
2022-2024
Southwest University
2024
Chinese Academy of Sciences
2023
As a reversible scar repair reaction, liver fibrosis can be blocked or even reversed by proper intervention during its formation. Our work suggests that acid-sensitive ion channel 1a (ASIC1a) participates in and presents novel mechanism involving m6 A modification miR-350/SPRY2. We demonstrated the expression of ASIC1a was significantly increased tissue patients with animal models fibrosis, as well PDGF-BB-induced activated HSC-T6. After downregulating ASIC1a, degree is reduced HSC...
Abstract Chronic alcohol consumption is a major risk factor for alcoholic steatohepatitis (ASH). Previous studies have shown that direct injury of hepatocytes the key in its occurrence and development. However, our study shows role Kupffer cells ASH cannot be ignored. We isolated from livers mice found induced cell pyroptosis increased release interleukin‐1β (IL‐1β). Furthermore, we screened related m6A enzyme methyltransferase‐like 3 (METTL3) liver cells, silencing METTL3 alleviated...
Acid-sensing ion channel 1a (ASIC1a) allows Na+ and Ca2+ flow into cells. It is expressed during inflammation, in tumour ischaemic tissue, the central nervous system non-neuronal injury environments. Endoplasmic reticulum stress (ERS) caused by accumulation of misfolded proteins that interferes with intracellular calcium homoeostasis. Our recent reports showed ASIC1a ERS are involved liver fibrosis progression, particularly hepatic stellate cell (HSC) activation. In this study, we...
Abstract Background Colorectal adenomatous polyps (CAPs) are considered precancerous lesions of colorectal cancer (CRC). The gut microbiota participates in the process digestion and, process, produces metabolites, mainly short-chain fatty acids (SCFAs), secondary bile and conjugated linoleic acid (CLA). This study aimed to investigate constituents metabolites faeces CAP patients identify or that can be used as sensitive biological predictors provide a theoretical basis for clinical treatment...
// Jing Zhang 1, * , Lei Liu 2, Yunyan Sun 1 Jiandong Xiang Dongmei Zhou Li Wang Huali Xu Xiaoming Yang Na Du Meng 3 Qin Yan Xiaowei Xi Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People’s Hospital, Shanghai, China 2 Ren Ji School Medicine, University, Pathology, Fudan Cancer Center, These authors contributed equally to this work Correspondence to: Xi, e-mail: xixiaowei1966@126.com Yan, yanqin76@126.com Keywords: miR-520g, epithelial ovarian...
Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) plays a vital role in the development of malignant tumors; however, its biological and underlying mechanism epithelial ovarian cancer (EOC) remain unclear. In this study, we aimed to investigate function clinical significance LGR5 human EOC. We evaluated expression EOC cell lines tissues from patients by qPCR, Western blotting, immunohistochemical analysis. Cell proliferation, colony formation, transwell invasion assay,...
Hepatitis B virus (HBV) is a top contributor to hepatoma. Circular RNAs (circRNAs) have been elucidated close connection with HBV-induced This study aimed explore the role of circRNA BTB domain and CNC homolog 1 (circBACH1) in HBV replication hepatoma progression, as well potential mechanistic pathway.Quantitative real-time polymerase chain reaction (qRT-PCR) assay was performed assess expression circBACH1, microRNA (miR)-200a-3p, mitogen-activated protein kinase 2 (MAP3K2). determined by...
Background Despite advancements in medical examination equipment and techniques, fever of unknown origin (FUO) remains challenging internal medicine. Purpose This study evaluates the diagnostic efficacy necessity 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) patients with FUO. Methods We retrospectively analyzed results 18F-FDG PET/CT a cohort 284 FUO admitted to Department Infection at First Hospital Jilin University between January 2018 March...
A number of studies have demonstrated that resveratrol (RES) has a variety biological functions, including cardiovascular protective effects, treatment mutations, and anti‑inflammatory, anti‑tumor antiviral effects. In the present study, RES‑loaded nanoparticles (RES‑NPs) were used to protect rhabdosarcoma (RD) cells from enterovirus 71 (EV71) infection, relevant mechanisms also explored. An amphiphilic copolymer, monomethoxy poly (ethylene glycol)‑b‑poly (D,L‑lactide), was as vehicle...
The formation of keloid scars is normally induced by cutaneous injuries, however, the detailed mechanisms underlying remain largely unknown. present study aimed to investigate effects circular RNA_101238 (circ_101238) on proliferation and apoptosis fibroblasts identify molecular these effects. Reverse transcription-quantitative (RT-q)PCR was performed determine expression levels circ_101238, microRNA (miRNA/miR)-138-5p cyclin-dependent kinase 6 (CDK6) in keloids normal skin tissues....
This study aimed to analyze the clinical significance of serum ferritin, procalcitonin (PCT), and C-reactive protein (CRP) in patients with hemorrhagic fever renal syndrome (HFRS). The demographical, clinical, laboratory data 373 HFRS northeastern China were retrospectively analyzed. levels ferritin PCT severe (n = 108) significantly higher than those mild 265, p < 0.001) associated severity. area under receiver operating characteristic curve (AUC) values for predicting severity 0.732 (95%...
In clinical practice, some patients diagnosed with anxiety disorder (AD) may develop bipolar (BD) many years later, and cases of AD be cured by the use mood stabilizers. However, relationship between BD should explored further. To track how turned to discover differences them, we recruited 48 BD, who were assigned group for retrospective analysis, also 186 at enrolment; this latter was asked complete follow-up surveys conducted 3 months, 6 12 months 18 after primary stage study. We defined...
Gene expression and DNA methylation levels affect the outcomes of patients with cancer. The present study aimed to establish a multigene risk model for predicting cervical cancer (CerC) treated or without radiotherapy. RNA sequencing training data matched profiles were downloaded from Cancer Genome Atlas database. Patients divided into radiotherapy non‑radiotherapy groups according treatment strategy. Differently expressed methylated genes between two identified, 8 prognostic identified...
Abstract Purpose To explore the relationships between episcleral hemangioma distribution patterns and trabeculotomy prognosis in young Sturge–Weber syndrome (SWS) patients. Methods syndrome‐induced glaucoma patients less than 4 years of age who underwent our Ophthalmology Department from February 2016 to June 2017 were included. Every patient could be divided into simple vascular abnormal network (SEVAN) or multiple (MEVAN) groups according their patterns. The intraocular pressure (IOP) was...
Increasing evidence shows that the calpain regulatory subunit Capn4 can modulate proliferation and metastasis of cancer cells, plays an important role in development malignant tumors. However, there is no information on clinical significance epithelial ovarian carcinoma (EOC) or molecular mechanisms by which promotes growth EOC. Therefore, aim this study was to clarify EOC.We evaluated osteopontin (OPN) expression EOC cell lines tissues from patients with western blotting immunohistochemical...
Hand, foot, and mouth disease (HFMD) have been recognized over the past several years as a highly infectious in children. Enterovirus 71 (EV71) coxsackievirus A16 (CVA16) are two major causative agents. The objective of this study was to determine optimal time method HFMD detection, explore seroconversion IgM IgG antibodies, examine response neutralizing antibody (NtAb) EV71 or CVA16. Between January 2016 December 2017, total 460 patients, diagnosed with based on clinical symptoms...
Tumor-related coagulation dysfunction has been reported to be closely associated with poor prognosis. The present study is aimed evaluate the prognostic prediction of an elevated plasma D-dimer cut-off value in advanced non-small cell lung cancer (NSCLC).A total 233 patients initially diagnosed NSCLC were retrospectively analyzed, 981 ng/mL D-dimer, which was instead clinical 500 mg/mL, used determine high and low. Univariate analysis using Kaplan-Meier method log-ranking test, multivariate...