A5101681174- Congenital Heart Disease Studies
- Tracheal and airway disorders
- Coronary Artery Anomalies
- Congenital Diaphragmatic Hernia Studies
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Diabetes Treatment and Management
- Cardiac Fibrosis and Remodeling
- Cardiovascular and Diving-Related Complications
- Mitochondrial Function and Pathology
- Aortic Disease and Treatment Approaches
- ATP Synthase and ATPases Research
- Vascular Anomalies and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- Cardiac Arrhythmias and Treatments
- Cardiovascular Health and Disease Prevention
- Intensive Care Unit Cognitive Disorders
Guangzhou Medical University
2015-2025
Third Affiliated Hospital of Guangzhou Medical University
2025
First Hospital of Lanzhou University
2012-2024
Lanzhou University
2012-2024
Guangzhou Women and Children Medical Center
2013-2023
Central South University
2022
Ningxia Medical University
2014-2022
Xiangya Hospital Central South University
2022
First Affiliated Hospital of Chinese PLA General Hospital
2014
TED University
2014
Background: Given the importance of microvascular injury in infarct formation and expansion, development therapeutic strategies for protection against myocardial ischemia/reperfusion (IRI) is great interest.Here, we explored molecular mechanisms underlying protective effects SGLT2 inhibitor dapagliflozin (DAPA) cardiac dysfunction mediated by IRI.Methods: DAPA were evaluated both vivo, mice subjected to IRI, vitro, human coronary artery endothelial cells (HCAECs) exposed...
Abstract Background Empagliflozin has been reported to protect endothelial cell function, regardless of diabetes status. However, the role empagliflozin in microvascular protection during myocardial ischemia reperfusion injury (I/R) not fully understood. Methods Electron microscopy, western blots, immunofluorescence, qPCR, mutant plasmid transfection, co-immunoprecipitation were employed explore whether could alleviate damage and cardiac I/R injury. Results In mice, attenuated injury-induced...
Mitochondrial dysfunction has been suggested to be the key factor in development and progression of cardiac hypertrophy. The onset mitochondrial mechanisms underlying hypertrophy (CH) are incompletely understood. present study is based on use multiple bioinformatics analyses for organization analysis scRNA‐seq microarray datasets from a transverse aortic constriction (TAC) model examine potential role pathophysiology CH. results showed that NADH:ubiquinone oxidoreductase core subunit S1‐...
Limited study has shown whether NT-proBNP is related to the prognosis of children wth ventricular septal defect (VSD) surgery. The was conducted determine predictive value on outcomes with VSD A total 798 surgery were enrolled, measured at preoperatively and 24-h postoperatively. short- mid-term clinical recorded. Propensity scores (PS) performed acquire pre-op post PS-matched cohorts for comparisons between groups. In pre cohort, higher NT pro-BNP group had longer hospitalization time lower...
The present study aimed to analyze the risk factors affecting prognosis children with fulminant myocarditis. medical records of all patients (n = 40) who were diagnosed myocarditis and admitted Cardiac Intensive Care Unit (CICU) Pediatric (PICU) at Guanzhou Women Children's Medical Center, Guangzhou University between January 2014 December 2023 retrospectively analyzed. Patients divided into two groups based on their in-hospital prognosis, namely, a survival group 32) an non-survival 8)....
<title>Abstract</title> <bold>Introduction</bold> Heart failure with preserved ejection fraction（HFpEF） constitutes nearly half of patients heart failure, but there is still a lack treatment options to improve prognosis. Empagliflozin one the novel hypoglycemic agent sodium glucose cotransporter 2 inhibitors（SGLT2i），however, its impact on exercise tolerance in HFpEF remains unclear. Further clinical investigations are warranted elucidate role SGLT2i HFpEF. This study aims evaluate efficacy...
Ischemic stroke (IS) is a multifactorial disease caused by the interaction of variety environmental and genetic factors, which can lead to severe disability heavy social burden. This study aimed find potential biomarkers related T cell exhaustion (TEX) in IS. Based on GSE16561 dataset, differentially expressed genes (DEGs) were screened from IS control groups, their enriched biological pathways explored. The TEX enrichment score for each sample was calculated using GSEA algorithm, gene...
<b><i>Objectives:</i></b> Heterotaxy syndrome is a recognized risk factor for surgical cardiac interventions. We evaluated the early- and middle-term results of intervention patients with heterotaxy syndrome. <b><i>Methods:</i></b> A total 42 were enrolled (September 2008 to March 2015). Left right atrial isomerism identified in 26% (11 out 42) 74% (31 42), respectively. The median age at time surgery was 6.8 months (range: 5 days 22.3 years)....
To describe the prevalence and demographic characteristics of corneal blindness in an urban rural region Ningxia, located northwest part China.A stratified, randomized sampling procedure was employed study, including area all age group. Visual acuity, anterior segment ocular fundus were checked. Related factor disease, age, gender, education status, ethnic group, location occupation, identified according to uniform customized protocol. An eye defined be if visual acuity <20/400 due a...
Myocardial ischemia-reperfusion (I/R) damage is characterized by mitochondrial in cardiomyocytes.Transmembrane BAX inhibitor motif containing 6 (TMBIM6) and presenilin-2 (PS2) participate multiple pathways; thus, we investigated the impact of these proteins on homeostasis during an acute reperfusion injury.Myocardial post-ischemic stress impaired myocardial function, induced structural abnormalities promoted cardiomyocyte death disrupting integrity wild-type mice, but not TMBIM6 transgenic...
Background Disturbed cerebral autoregulation has been reported in children with congenital heart disease before and during cardiopulmonary bypass surgery, but not after. We sought to characterize the status early postoperative period relation perioperative variables brain injuries. Methods Results A prospective observational study was conducted 80 patients first 48 hours following cardiac surgery. Cerebral oximetry/pressure index (COPI) retrospectively calculated as a moving linear...
Abstract Background To detect the development, function and therapeutic potential of epicardial adipose tissue (EAT); analyze a related gene expression dataset, including data from neonates, infants, children with congenital heart disease (CHD); compare to identify codifferentially expressed (DE) mRNAs lncRNAs corresponding miRNAs; generate competitive endogenous RNA (ceRNA) network; assess involvement immunocyte infiltration in development EAT. Methods Multiple algorithms for linear models...
The aim of this study was to review the early and mid-term outcomes total cavopulmonary connection (TCPC) procedure evaluate risk factors for prolonged pleural effusions.The clinical records 82 consecutive patients, who underwent a TCPC operation between January 2008 December 2013, were reviewed incidence effusions, duration ventilation time drainage, length intensive care unit (ICU) stay, morbidity mortality.The median age at surgery 3.0 years. main single ventricle diagnoses included 18...
The postoperative risk factors for electroencephalogram(EEG) abnormalities after paediatric cardiopulmonary bypass (CPB) remain to be identified. We investigated the characteristics of EEG and in routine clinical management post-CPB.EEG cerebral oxygen saturation (ScO2) were monitored 96 patients (aged 3 days, 37 months, median 5 months) 72 h post-CPB. Clinical measurements included 4-hourly arterial central venous pressure, blood gases, doses inotropic vasoactive drugs, daily C-reactive...
Objective: Adverse factors of postoperative hemodynamic and myocardial performance remain largely unexplored in children with congenital heart disease following cardiopulmonary bypass due to technical limitations. Pressure recording analytical method (PRAM) is a continuous monitoring technique based on beat-to-beat arterial pressure waveform. Using PRAM, we examined the temporal trends adverse factors, clinical management, these performances. Methods: We monitored blood pressure, cardiac...
Objectives Dysnatremia is a common electrolyte disturbance after cardiopulmonary bypass (CPB) surgery for congenital heart disease (CHD) and known risk factor adverse neurological events clinical outcomes. The objective of this study was to evaluate the association dysnatremia with worse abnormal EEG patterns, brain injuries detected by magnetic resonance imaging (MRI) early Methods We monitored continuous in 340 children during initial 48 h following cardiac surgery. Demographics...
To screen mutations in the retinitis pigmentosa 1 (RP1) gene and rhodopsin (RHO) Chinese patients with sine pigmento (RPSP) describe genotype-phenotype relationship of mutations.Twenty affected, unrelated individuals RPSP (4 autosomal dominant RPSP, 12 recessive 4 unknown inheritance pattern) were recruited between 2009 2012. The clinical features determined by complete ophthalmologic examinations. Polymerase chain reaction (PCR) direct DNA sequencing used to entire coding region splice...