A5100601551- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Axon Guidance and Neuronal Signaling
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Fibrosis and Remodeling
- ATP Synthase and ATPases Research
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Iron Metabolism and Disorders
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Advanced biosensing and bioanalysis techniques
- interferon and immune responses
- Hippo pathway signaling and YAP/TAZ
- Maternal Mental Health During Pregnancy and Postpartum
- Memory and Neural Mechanisms
Nanjing University of Chinese Medicine
2011-2024
Jiangsu Province Hospital
2011-2024
Northeast Agricultural University
2024
Nankai University
2023
Guangzhou Medical University
2020-2021
Nanjing Medical University
2008-2020
Nanjing University
2020
Liaocheng People's Hospital
2017
Medical University of South Carolina
2008
NLRP3 inflammasome is a critical part of the innate immune system and plays an important role in variety inflammatory diseases. However, effects on periodontitis have not been fully studied.We used ligature-induced models knockout mice (NLRP3KO ) their wildtype (WT) littermates to compare alveolar bone phenotypes. We further Lysm-Cre/RosanTnG mouse trace changes Lysm-Cre+ osteoclast precursors with or without MCC950 treatment. At last, we explored as potential drug for treatment vivo...
Abstract Cognitive deficits, including spatial memory impairment, are very common after ischemic stroke. Neurogenesis in the dentate gyrus (DG) contributes to forming brain. Fluoxetine, a selective serotonin reuptake inhibitor, can enhance neurogenesis hippocampus physiological situations and some neurological diseases. However, whether it has effects on ischemia‐induced cognitive impairment hippocampal not been determined. Here we report that fluoxetine treatment (10 mg kg −1 , i.p.) for 4...
Abstract Peripheral stimulation and physical therapy can promote neurovascular plasticity functional recovery after CNS disorders such as ischemic stroke. Using a rodent model of whisker‐barrel cortex stroke, we have previously demonstrated that whisker activity promotes angiogenesis in the penumbra barrel cortex. This study explored potential increased peripheral to neurogenesis neural progenitor migration toward Three days focal ischemia adult mice, whiskers were manually stimulated (15...
Mitochondrial dysfunction has been suggested to be the key factor in development and progression of cardiac hypertrophy. The onset mitochondrial mechanisms underlying hypertrophy (CH) are incompletely understood. present study is based on use multiple bioinformatics analyses for organization analysis scRNA‐seq microarray datasets from a transverse aortic constriction (TAC) model examine potential role pathophysiology CH. results showed that NADH:ubiquinone oxidoreductase core subunit S1‐...
Mechanical force across sutures is able to promote suture osteogenesis. Orthodontic clinics often use this biological characteristic of treat congenital cranio-maxillofacial malformations. However, the underlying mechanisms still remain poorly understood. Craniofacial provide a special growth source and support primary sites Here, we isolated rat sagittal cells (rSAGs), which had mesenchymal stem cell characteristics differentiating abilities. Cells were then subjected mechanical tension (5%...
Qishen Gubiao granules, a traditional Chinese medicine preparation composed of nine herbs, have been widely used to prevent and treat coronavirus disease 2019 with good clinical efficacy. In the present study, an integrated strategy based on chemical profiling followed by network pharmacology molecular docking was employed, explore active components potential mechanisms granules in therapy 2019. Using ultra‐high performance liquid chromatography coupled quadrupole time‐of‐flight mass...
Abstract Background To detect the development, function and therapeutic potential of epicardial adipose tissue (EAT); analyze a related gene expression dataset, including data from neonates, infants, children with congenital heart disease (CHD); compare to identify codifferentially expressed (DE) mRNAs lncRNAs corresponding miRNAs; generate competitive endogenous RNA (ceRNA) network; assess involvement immunocyte infiltration in development EAT. Methods Multiple algorithms for linear models...
Aim and Objective: Zuogui pill (ZGP) is the traditional Chinese medicine for tonifying kidney yin. Clinical animal studies have shown that ZGP effectively enhances neurologic impairment after ischemic stroke, which may be related to promoting neurite outgrowth. This investigation aimed prove pro-neurite outgrowth impact of define underlying molecular pathway in vitro. Materials Methods:: The major biochemical components were investigated using UPLC-QTOF-MS. All-trans retinoic acid (ATRA) was...
Neural stem cell (NSC) transplantation has emerged as a promising approach for the treatment of neurological disorders such cerebral ischemia. As majority newly generated cells from exogenous NSCs fail to integrate into ischemic brain and establish functional synaptic networks, NSC stroke experiences limited function recovery. Augment endogenous neurite growth in process differentiation is an avenue promote networks. Phosphatase tensin homolog (PTEN), tumor suppressor, been established...
Mesenchymal stem cells (MSCs) have been intensively investigated and widely applied in regenerative medicine immune modulation. However, their efficacy declines during the aging or disease process. Thus, genome-edited MSCs with over-expression inhibition of specific genes hold a great deal promise terms therapeutic application. Here we optimized direct PCR approach for rapid identification only ten required, which reduces time labor to expand MSC colonies. Combined our previously guide RNA...
Background/Aims: The target genome editing technology not only plays an important role in basic biology studies but also holds a great promise for potential clinical applications. new generation of engineered nuclease RGEN (RNA Guided EndoNuclease) is much easier to construct and modify, attracts more attentions. In the current study, we compared different plasmid construction strategies Cas9-gRNA (guide RNA). Methods: Different were compared. And modifications introduced into strategy....
Abstract Background: Immune-inflammatory mediators might modulate a wide range of immune and inflammatory processes，resulting in an increased risk depression. The objective this study was to assess the association between Systemic Immune-inflammation Index (SII) depression through population-based retrospective cohort National Health Nutrition Examination Survey from 2005 2020. Methods: 2005–2020 data enrolled participants were selected. Among them, non-pregnant adults with complete SII...
Abstract Background This study aimed to unravel the heterogeneity of cardiomyocytes and probed out hub genes pathways for cardiac hypertrophy based on transverse aortic constriction (TAC) mouse models using single-cell RNA sequencing (scRNA-seq). Methods scRNA-seq data TAC were retrieved from GSE95140 dataset. After filtering, cell clusters detected data, followed by identification differentially expressed (DEGs). Then, functional enrichment analysis DEGs was presented. GSVA scores...