A5084692665- Effects and risks of endocrine disrupting chemicals
- Computational Drug Discovery Methods
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Pharmaceutical and Antibiotic Environmental Impacts
- Toxic Organic Pollutants Impact
- Cancer Immunotherapy and Biomarkers
- Environmental Toxicology and Ecotoxicology
- Animal testing and alternatives
- Estrogen and related hormone effects
- Metabolomics and Mass Spectrometry Studies
- Air Quality and Health Impacts
- Chemistry and Chemical Engineering
- Hematopoietic Stem Cell Transplantation
- Analytical chemistry methods development
- Health, Environment, Cognitive Aging
- Nutritional Studies and Diet
- Pharmacological Effects of Natural Compounds
- Air Quality Monitoring and Forecasting
- Thyroid Disorders and Treatments
- Metastasis and carcinoma case studies
- Neonatal Respiratory Health Research
- Phosphorus and nutrient management
- Chemical Analysis and Environmental Impact
- Environmental remediation with nanomaterials
State Key Laboratory of Pollution Control and Resource Reuse
2019-2025
Nanjing University
2019-2025
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Jiangsu Province Hospital
2023-2025
Nanjing University of Chinese Medicine
2023-2025
Tongji University
2022-2024
Ministry of Ecology and Environment
2022-2024
Shanghai Institute of Pollution Control and Ecological Security
2022
Xian Center for Disease Control and Prevention
2017-2022
The rapid increase in both the quantity and complexity of data that are being generated daily field environmental science engineering (ESE) demands accompanied advancement analytics. Advanced analysis approaches, such as machine learning (ML), have become indispensable tools for revealing hidden patterns or deducing correlations which conventional analytical methods face limitations challenges. However, ML concepts practices not been widely utilized by researchers ESE. This feature explores...
While capacitive deionization (CDI) is a promising technology for the recovery of nutrients from wastewater, selective phosphate wastewater containing high concentrations competing ions still huge challenge. Herein, we reported ferrocene-polyaniline-functionalized carbon nanotube (Fc-PANI/CNT) electrode prepared through amidation reaction and chemical oxidation polymerization, aiming highly phosphorus wastewater. The Fc-PANI/CNT with unique structure conductivity could efficiently adsorb...
Objectives The prevalence of cardiovascular disease risk factors has increased worldwide. However, the and clustering among Tibetans is currently unknown. We aimed to explore Tibetan adults in China. Methods In 2011, 1659 (aged ≥18 years) from Changdu, China were recruited this cross-section study. questionnaire, physical examinations laboratory testing completed factors, including hypertension, diabetes, overweight/obesity, dyslipidemia, current smoking, counted. association between...
Although previous studies have confirmed the association between phthalate esters (PAEs) exposure and endocrine disorders in humans, few to date systematically assessed threats of new PAE alternatives disruptions. Herein, zebrafish embryos were continuously exposed two PAEs [di-n-butyl (DBP) diisobutyl (DiBP)], structurally related [diiononyl (DINP) diisononyl hexahydrophthalate (DINCH)], non-PAE substitutes [dipropylene glycol dibenzoate (DGD) glyceryl triacetate (GTA)],...
Endocrine-disrupting chemicals (EDCs) can inadvertently interact with 12 classic nuclear receptors (NRs) that disrupt the endocrine system and cause adverse effects. There is no widely accepted understanding about what structural features make thousands of EDCs able to activate different NRs as well how these exert their functions induce outcomes at cellular level. This paper applies hierarchical characteristic fragment methodology high-throughput screening molecular docking comprehensively...
Antimicrobial transformation products (ATPs) in the environment have raised extensive concerns recent years due to their potential health risks. However, only a few ATPs been investigated, and most of pathways antimicrobials not completely elucidated. In this study, we developed nontarget screening strategy based on molecular networks detect identify pharmaceutical wastewater. We identified 52 49 (TPs) with confidence level three or above. Thirty TPs had previously reported environment....
Background and Purpose—Early presentation is critical for receiving effective reperfusion therapy acute ischemic stroke, therefore, we undertook a national survey of awareness responses to stroke symptoms in China. Methods—We cross-sectional community-based study 187 723 adults (age ≥40 years) presenting 69 administrative areas across China between January 2017 May determine the recognition rate correct action rate. Multivariable logistic regression models were used identify factors...
Since a large number of contaminants are detected in source waters (SWs) and tap (TWs), it is important to perform comprehensive effect evaluation key contributor identification. A reduced human transcriptome (RHT)-based effect-directed analysis, which consisted concentration-dependent RHT reveal the effects noteworthy pathways systematic identification contributors based on interactions between compounds pathway effects, was developed applied typical SWs TWs along Yangtze River. By RHT, 42%...
A growing number of environmental contaminants have been proved to reproductive toxicity males and females. However, the unclear toxicological mechanism toxicants limits development virtual screening methods. By consolidating androgen (AR)-/estrogen receptors (ERs)-mediated adverse outcome pathways (AOPs) with more than 8000 chemical substances, we uncovered relationships between features, a series pathway-related effects, apical outcomes─changes in sex organ weights. An AOP-based...
Ubiquitous chemicals in the environment may pose a threat to human health and ecosystem, so comprehensive toxicity information must be obtained. Due inability of traditional experimental methods meet needs testing large number chemicals, vivo vitro assays have been shifted new paradigm, computer-assisted virtual screening. However, commonly used screening techniques, including read-across machine learning-based quantitative structure–activity relationship (QSAR), limitations assessing...
Short-chain chlorinated paraffins (SCCPs) have attracted attention because of their toxicological potential in humans and wildlife at environmentally relevant doses. However, limited information is available regarding mechanistic differences across species terms the biological pathways that are impacted by SCCP exposure. Here, a concentration-dependent reduced human transcriptome (RHT) approach was conducted to evaluate 15 SCCPs HepG2 cells compared with our previous results using zebrafish...
The difficulty in associating diverse pollutants with mixture effects has led to significant challenges identifying toxicants combined pollution. In this study, pathways were used link and toxicants. By evaluated by the concentration-dependent transcriptome, individual extended molecular mechanisms encompassing 135 corresponding 6 biological processes. Accordingly, mechanism-based identification of was achieved constructing a pathway toxicant database containing 2413 chemical–pathway...
Heavy metals complexed with organic ligands are among the most critical carcinogens threatening global water safety. The challenge of efficiently and cost-effectively removing recovering these has long eluded existing technologies. Here, we show a strategy coordinating mediator-based electro-reduction (CMBER) for single-step recovery heavy from wastewater contaminated metal-organic complexes. In CMBER, amidoxime superior abilities over traditional is immobilized by an amidoximation reaction...
Safer chemical alternatives to bisphenol (BP) have been a major pursuit of modern green chemistry and toxicology. Using similarity-based approach, it is difficult identify minor structural differences that contribute the significant changes toxicity. Here, we used omics computational toxicology features associated with BP analogue-induced embryonic toxicity, offering valuable insights inform design safer alternatives. The zebrafish acute behavioral effects, concentration-dependent...
Abstract In this prospective, open-label, exploratory study (RENMIN-213), patients with previously untreated, HER2-negative, advanced G/GEJ adenocarcinoma signet ring cell carcinoma or peritoneal metastasis, were enrolled to receive 8 cycles of apatinib, tislelizumab, and chemotherapy every 3 weeks, a maintenance therapy apatinib plus tislelizumab for maximum 1 year. Homogeneous receiving ICIs combined at the same time deemed as control group efficacy. The primary endpoint was...
Background: The intricate relationship between the gut microbiome and myopia is increasingly recognized, underscoring need to explore its causal dynamics. Despite emerging evidence, influence of Gut Microbiota (GM) on ocular development remains underexplored. Methods: This study utilized Mendelian Randomization (MR) investigate impact GM myopia. Instrumental variables (IVs) were identified from Genome- Wide Association Studies (GWAS), focusing genetic variants significantly associated with...
<p>Supplementary Figure 2. Waterfall plot for tumor markers change is shown 33 patients who had unresectable advanced or recurrent gastric gastroesophageal junction adenocarcinoma after receiving apatinib combined with tislelizumab and chemotherapy. Increase range more than 100% considered as 100%.</p>
<p>Supplementary Figure 1. Overall survival for patients received apatinib combined with tislelizumab and chemotherapy. The median overall reached 20.9 months (95% CI: 14.60–27.20).</p>
<div>Abstract<p>In this prospective, open-label, exploratory study (RENMIN-213), patients with previously untreated, HER2-negative, advanced G/GEJ adenocarcinoma signet ring cell carcinoma or peritoneal metastasis were enrolled to receive eight cycles of apatinib, tislelizumab, and chemotherapy every 3 weeks, a maintenance therapy apatinib plus tislelizumab for maximum 1 year. Homogeneous receiving immune checkpoint inhibitors combined at the same time deemed as control group...