A5100342831- Traditional Chinese Medicine Studies
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Maternal Mental Health During Pregnancy and Postpartum
- Acute Ischemic Stroke Management
- Medical Research and Treatments
- Healthcare and Venom Research
- Urological Disorders and Treatments
- Neuroscience of respiration and sleep
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Corneal Surgery and Treatments
- Pediatric health and respiratory diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Acupuncture Treatment Research Studies
- Energy and Environment Impacts
- Pressure Ulcer Prevention and Management
- CCD and CMOS Imaging Sensors
- Signaling Pathways in Disease
- Cancer, Lipids, and Metabolism
- Stress Responses and Cortisol
- Oral microbiology and periodontitis research
- COVID-19 Clinical Research Studies
Shanghai First Maternity and Infant Hospital
2025
Southern Medical University
2017-2025
Nanfang Hospital
2020-2025
Key Laboratory of Guangdong Province
2025
Shenzhen Children's Hospital
2025
Shanghai Sixth People's Hospital
2018-2024
Shanghai Jiao Tong University
2018-2024
Tianjin Municipal Research Institute for Family Planning
2018-2024
Nanjing Normal University
2023-2024
Chinese National Human Genome Center
2017-2024
Abstract There is a clinical need to predict sensitivity of metastatic hormone receptor-positive and HER2-negative (HR+/HER2−) breast cancer endocrine therapy, targeted RNA sequencing (RNAseq) offers diagnostic potential measure both transcriptional activity functional mutation. We developed the SET ER/PR index gene expression microarray probe sets that were correlated with receptors ( ESR1 PGR ) robust preanalytical analytical influences. tested in biopsies metastastic HR+/HER2− against...
Plants adapt their growth and development in response to perceived salt stress. Although DELLA-dependent restraint is thought be an integration of the plant's stress, little known about how histone modification confers stress and, turn, affects development. Here, we report that floral initiator Shk1 kinase binding protein1 (SKB1) histone4 arginine3 (H4R3) symmetric dimethylation (H4R3sme2) integrate responses plant developmental progress Mutation SKB1 results hypersensitivity, late...
Abstract To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting total 1,782 plasma samples from 869 donors Wuhan, China and test specific antibody responses. The results show that positive rate IgG against receptor-binding domain spike protein (RBD-IgG) to severe acute respiratory syndrome 2 (SARS-CoV-2) COVID-19 exceeded 70% for 12 months post diagnosis. level RBD-IgG...
Most evidences regarding ambient PM2.5 or PM10 (particulate matter of median aerodynamic diameter ≤2.5 μm ≤10 μm) and preterm birth (PTB) come from western countries which has relatively low PM pollution exposure, the results are still inconsistent. This study aims to examine whether exposure high concentrations was associated with PTB (<37 weeks) near term (37-38 weeks).We established a cohort 1,280,524 singleton pregnancies who delivered Dec 1st, 2013 Nov 30th, 2014 matched their home...
Diabetic nephropathy (DN) is characterized by inflammation of renal tissue. Glomerular endothelial cells (GEnCs) play an important role in and protein leakage urine DN patients. Chemerin its receptor ChemR23 are inducers inflammation. The aim this study was to investigate the function chemerin/ChemR23 GEnCs Immunohistochemical staining qRT-PCR were used measure expression chemerin, inflammatory factors tissues Db/db mice as animal model. knocked down injecting LV3-shRNA into tail vein....
Background Epidemiological evidence on the association between long‐term exposure to ambient fine particulate matter (with an aerodynamic diameter ≤2.5 μm; PM 2.5 ) and hypertension is mixed. We investigated particles in reproductive‐age adults. Methods Results This analysis included 39 348 119 (20–49 years) participants from National Free Preconception Health Examination Project April 22, 2010 December 31, 2015 across China. The estimation of annual average concentrations for each community...
Background and Purpose—Early presentation is critical for receiving effective reperfusion therapy acute ischemic stroke, therefore, we undertook a national survey of awareness responses to stroke symptoms in China. Methods—We cross-sectional community-based study 187 723 adults (age ≥40 years) presenting 69 administrative areas across China between January 2017 May determine the recognition rate correct action rate. Multivariable logistic regression models were used identify factors...
Introduction Previous studies have shown that obesity has a positive effect on bone mineral density (BMD). However, excessive is harmful to health, especially in older adults. In addition, it unclear what body mass index (BMI) and waist circumference (WC) maintain for the most beneficial BMD Methods Multivariate logistic regression models were used investigate association between BMI, WC, femoral neck using recent data from 2017–2020 National Health Nutrition Examination Survey (NHANES)....
The goal of this study was to estimate the relationships among principal leadership, teacher-related factors (e.g. job satisfaction, self-efficacy teaching, and collaboration), student achievement in science. With United States sample Programme for International Student Assessment (PISA) 2015 data, we used a series two-level structural equation models examine direct, indirect, moderated effect leadership. results revealed that (a) teachers' rating leadership had direct positive relationship...
<h3>Importance</h3> Maternal thyrotropin levels during gestation have a profound effect on pregnancy outcomes; however, few studies to date evaluated the importance of preconception levels. <h3>Objective</h3> To investigate associations between and outcomes. <h3>Design, Setting, Participants</h3> This population-based cohort study enrolled Chinese women aged 20 49 years from National Free Prepregnancy Checkups Project in China. Participants conceived within 6 months after examination...
Abstract Background Comorbidities, any other coexisting diseases in patients with a particular index disease, are known to increase the mortality of stroke. However, association pre-existing comorbidities stroke risk has not been fully studied. Methods This study included 16,246 adults from prospective community-based cohort baseline survey conducted 2013 China. Participants were followed up hospitalization records and Cause Death Registry. The eight (coronary heart hyperlipidemia,...
Accurate pretreatment prediction for disease progression of nasopharyngeal carcinoma is key to intensify therapeutic strategies high-risk individuals. Our aim was evaluate the value baseline MRI-based radiomics machine-learning models in predicting patients who achieved complete response after treatment.In this retrospective study, 171 with pathologically confirmed were included. Using hold-out cross validation scheme (7:3), relevant radiomic features selected least absolute shrinkage and...
Background: Older patients undergoing noncardiac surgery are at risk of postoperative cardiovascular events. Accurate assessment is important for informed decision-making. Methods: This prospective cohort study enrolled older elective major surgery. A frailty index based on preoperative geriatric assessments (FI-PGA) was constructed using 32 health-related parameters. The primary outcome the occurrence any events within 30 days after associations between FI-PGA and outcomes were assessed...
Background The effect of second‐hand smoking, especially husband on wife's hypertension has not been well studied. current study was aimed to assess the association smoking with among females aged 20 49 years. Methods and Results This included 5 027 731 along their husbands from National Free Pre‐pregnancy Checkup Projects conducted across 31 provinces in China 2014. Smoking/passive status collected by a standard questionnaire blood pressure measured an electronic device after 10 minutes...
Abdominal aortic aneurysm (AAA) affects more than 5% of the population in developed countries and pharmacotherapies for AAA are limited. Here, we explored whether melatonin regulates development AAA. In smooth muscle cells, treatment decreases angiotensin II-induced matrix metalloproteinase 2 (MMP2) MMP9 expression. Human antigen R (HuR) could bind with adenylateuridylate-rich elements MMP2 mRNAs 3' untranslated region, resulting increased stability mRNAs. HuR is required Moreover,...