A5066059009- Liver physiology and pathology
- Pancreatic function and diabetes
- Ubiquitin and proteasome pathways
- Erythrocyte Function and Pathophysiology
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
- Bioinformatics and Genomic Networks
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Microbial Metabolic Engineering and Bioproduction
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Yersinia bacterium, plague, ectoparasites research
- Hemoglobinopathies and Related Disorders
- Macrophage Migration Inhibitory Factor
- Acute Myeloid Leukemia Research
- Liver Disease and Transplantation
- Advanced Proteomics Techniques and Applications
- 14-3-3 protein interactions
- Organ Transplantation Techniques and Outcomes
Beijing Proteome Research Center
2016-2025
Beijing University of Technology
2023-2025
State Key Laboratory of Proteomics
2009-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023-2024
Tianjin University
2013-2023
Shanghai Jiao Tong University
2009-2023
Beijing Radiation Center
2009-2023
China National Biotechnology (China)
2023
Affiliated Hospital of Nantong University
2023
International Peace Maternity & Child Health Hospital
2021-2023
Thiolutin, an inhibitor of the BRISC deubiquitinating enzyme complex, specifically and potently inhibits NLRP3 inflammasome activation.
Abstract Background PCBP1 (or alpha CP1 or hnRNP E1), a member of the PCBP family, is widely expressed in many human tissues and involved regulation transcription, transportation process, function RNA molecules. However, role CD44 variants splicing still remains elusive. Results We found that enforced expression inhibited including v3, v5, v6, v8, v10 HepG2 cells, knockdown endogenous induced these splicing. Invasion assay suggested played negative tumor invasion re-expression v6 partly...
SALL4 plays important roles in the development and progression of many cancers. However, role molecular mechanism endometrial cancer remain elusive. In present research, we have demonstrated that expression was upregulated correlated positively with tumor stage, metastases poor survival patients. The overexpression promoted invasiveness cells, as indicated by upregulation mesenchymal cell marker N-cadherin downregulation epithelial E-cadherin, invasion assays vitro. Additionally, there also...
miRNA-486 (miR-486) was first identified from the human fetal liver cDNA library and considered to be associated with hepatocellular carcinoma (HCC) development. Its roles in regulation of HCC metastasis chemosensitivity have not been explored yet.miR-486 expression tissues, cell lines serum evaluated by real-time polymerase chain reaction. miR-486 overexpression or downregulation SMMC-7721/LM3 conducted lentivirus transfection. Cell proliferation, migration apoptosis were quantitated using...
Abraxas brother 1 (ABRO1) has been reported to be a component of the BRISC complex, multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. However, current knowledge functions ABRO1 is limited. Here we report frequently downregulated in human liver, kidney, breast and thyroid gland tumour tissues. Depletion cancer cells reduces p53 levels enhances clone formation cellular transformation. Conversely, overexpression suppresses cell proliferation p53-dependent manner. We...
// Chao Liu 1, 2, * , En-Dong Yun-Xiao Meng 3, Xiao-Ming Dong 4 Ya-Lan Bi 3 Huan-Wen Wu Yan-Chao Jin 2 Ke Zhao Jian-Jie Li 5 Miao Yu Yi-Qun Zhan Hui Chen Chang-Hui Ge Yang and Chang-Yan 1 An Medical University, Hefei, 230032, China State Key Laboratory of Proteomics, Beijing Proteome Research Center, Institute Radiation Medicine, Beijing, 100850, Department Pathology, Peking Union College Hospital, Chinese Academy Sciences College, Tsinghua 100730, Tianjin School Chemical Engineering...
In this paper, the preliminary application of a new type cement-based piezoelectric sensor developed recently for monitoring traffic flows is proposed and investigated. The was made by bonding between two cubes hardened cement sand paste with commercially available ceramic plate encapsulated sealant especially sensor's fabrication, its property tested dynamic loadings including harmonic loading, random pulse loading. Two experiments were carried out to prove feasibility reliability person...
A Yersinia pestis-human protein interaction network is reported here to improve our understanding of its pathogenesis. Up 204 interactions between 66 Y. pestis bait proteins and 109 human were identified by yeast two-hybrid assay then combined with 23 previously published construct a protein-protein network. Topological analysis the revealed that targeted significantly enriched in are central Analysis this showed signaling pathways important for host immune responses preferentially pestis,...
Early diagnosis and treatment of ulcerative colitis (UC) is clinically challenging. To overcome this problem, we explored the interrelated multiplex signaling pathway to identify molecular signatures in UC by using integrated strategy proteomics. Intestinal mucosa 12 cases normal controls underwent comparative proteomic analysis. A total 26 unique differential proteins were identified, including up-regulated 14 down-regulated group. protein cluster, consisting 11 involved p38...
The nonreceptor tyrosine kinase c-ABL controls cell growth but its contributions in solid tumors are not fully understood. Here we report that the Polo-like PLK1, an essential mitotic regulator, is important downstream effector of regulating cervical cancer. interacted with and phosphorylated PLK1. Phosphorylation PLK1 by inhibited ubiquitination degradation enhanced activity, leading to cell-cycle progression tumor growth. Both were overexpressed carcinoma. Notably, phosphorylation...
Abstract BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated pathophysiological of acute failure using mice model induced by D-galactosamine (D-GalN) plus lipopolysaccharide (LPS). We found expression components was dramatically increased kupffer cells (KCs) upon LPS treatment vitro or injection D-GalN-sensitized mice. D-GalN LPS-induced...
THAP11 physically interacts with PCBP1 by anti bait coimmunoprecipitation (View interaction) tag Interaction: 1, 2) and colocalize fluorescence microscopy
Toll‐like receptor‐5 (TLR5) signaling regulates the immune privileged status of liver and is involved in hepatic disorders. However, role TLR5 has not yet been investigated experimental models concanavalin A (Con A)–mediated injury. Here, we show that highly up‐regulated mononuclear cells mice during Con A–induced hepatitis. Increased mortality histopathology TLR5‐deficient correlated with excessive production proinflammatory cytokines, suggesting knockout were more susceptible to We also...
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder. Despite advancements in genetic research and novel therapies, ALS remains an incurable condition with limited treatment options poor prognosis. This study explores alternative approach to management through the Guan Yin Citta Dharma Door, spiritual practice rooted Buddhist principles. The integrates three core methods—making vows, reciting scriptures, performing life liberation—to address karmic causes of...