A5103239253- Endometrial and Cervical Cancer Treatments
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Listeria monocytogenes in Food Safety
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Nitric Oxide and Endothelin Effects
- Cancer-related molecular mechanisms research
- Management of metastatic bone disease
- Drug Solubulity and Delivery Systems
- Venomous Animal Envenomation and Studies
- Hedgehog Signaling Pathway Studies
- Healthcare and Venom Research
- Advanced Drug Delivery Systems
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Advanced Radiotherapy Techniques
- Cerebrospinal fluid and hydrocephalus
- Bacterial biofilms and quorum sensing
- Gastric Cancer Management and Outcomes
- Protist diversity and phylogeny
- Lung Cancer Treatments and Mutations
University of Shanghai for Science and Technology
2022-2025
Shaanxi Normal University
2025
Xuzhou Medical College
2021-2024
Xi'an Jiaotong University
2013-2024
Anhui Medical University
2016-2024
Lu'an First People's Hospital
2024
Jinzhou Medical University
2018-2023
Guiyang Medical University
2020-2023
Affiliated Hospital of Guizhou Medical University
2020-2023
Guangdong Pharmaceutical University
2012-2022
Abstract Background MicroRNAs are regulators that can play an essential role in tumorigenesis. Although miR-302 families have been suggested to be tumor repressors human cancer, the mechanism by which they suppress development remains defined. In this study, we discover miR302b suppresses proliferation may due directly targeting EGFR hepatocellular carcinoma (HCC). Methods QRT-PCR was used assess miR-302b and expression 27 pairs of clinical tissues their corresponding adjacent nontumorous...
Serotonin receptor 5-HT6 is involved in cognition and Alzheimer's disease (AD) development. However, the mechanism of AD pathology not clear. Since almost exclusively expressed primary cilia, using immunostaining we examined number cilia hippocampus animal model APP/PS1 mice. By overexpressing knocking down cultured hippocampal neurons, investigated roles alternating ciliary morphology. Furthermore, antagonist was applied to confirm its Morris water maze test, Y maze, fear conditioning. In...
Circulating tumor cells (CTC) have been represented by different phenotypes due to the epithelial–mesenchymal transition (EMT), which are epithelial CTC (E-CTC), mesenchymal (M-CTC), and mixed (epithelial, mesenchymal) (EM-CTC). Limited work has systematically discussed associations of number, especially proportions E-CTC, M-CTC, EM-CTC in total CTC, with colorectal cancer (CRC) progressions via a simple method high performances. To achieve this goal, paper presents fabrication novel...
Abstract Circulating tumor cells (CTCs) are widely considered as a reliable and promising class of markers in the field liquid biopsy. As CTCs undergo epithelial‐mesenchymal transition (EMT), phenotype detection heterogeneous based on EMT is great significance. In this report, an integrated analytical strategy that can simultaneously capture differentially detect epithelial‐ mesenchymal‐expressed bloods non‐small cell lung cancer (NSCLS) patients proposed. First, commercial biomimetic...
Acid-sensing ion channel 1a (ASIC1a) allows Na+ and Ca2+ flow into cells. It is expressed during inflammation, in tumour ischaemic tissue, the central nervous system non-neuronal injury environments. Endoplasmic reticulum stress (ERS) caused by accumulation of misfolded proteins that interferes with intracellular calcium homoeostasis. Our recent reports showed ASIC1a ERS are involved liver fibrosis progression, particularly hepatic stellate cell (HSC) activation. In this study, we...
MicroRNAs (miRNAs) are a class of small, non‑coding, endogenous RNAs that important in tumor cell biological processes as they regulate gene expression. miR-195 has been demonstrated to be repressor numerous types human cancer. However, the mechanism by which miR‑195 suppresses development remains elucidated. The aim this study was investigate effect on functions HepG2 hepatocellular carcinoma (HCC) cells and identify association between Wnt3a HCC. mRNA expression levels HCC tissues lines...
In this paper, we prepared doxorubicin-loaded folic acid-functionalized pH-sensitive photothermal therapy (PTT) traceable hollow mesoporous silica nanoparticles (DOX-HPCF) as a drug carrier for liver cancer treatment. According to TEM characterization, (HMSN) are monodispersed spherical particles with structure. vitro release experiments showed that HPCF exhibited release. Cell uptake was successfully absorbed by SMMC-7721 cells. addition, DOX-HPCF significantly inhibited the proliferation...
Hyaluronic acid functionalized mesoporous hollow alumina nanoparticles (HMHA) were used as a tumor-targeted delivery carrier for liver cancer therapy. Paclitaxel (PAC) incorporated in the by adsorption method was analyzed X-ray diffraction and differential scanning calorimetry. PAC found to be an amorphous state. The hyaluronic coated on surface of (MHA) regulated drug release rate loaded samples obtained sustained release. In vitro experiments demonstrated that paclitaxel-hyaluronic...
Superoxide dismutase 3 (SOD3) is an extracellular enzyme with the capacity to modulate redox conditions by catalyzing dismutation of superoxide hydrogen peroxide. In addition synthesis and release this protein via secretory pathway, several studies have shown that also localizes intracellular compartments in neutrophils macrophages. Here we show human macrophages SOD3 from compartment within 30 min following LPS stimulation. This acutely increases level on cell surface as well environment....
Listeria monocytogenes is a major foodborne pathogen that can adhere to or form biofilm on food contact surfaces, depending the environmental conditions. The purpose of this work determine adhesion and formation boundaries for L. ST9 under combination environments temperature (5, 15, 25 °C), NaCl concentration (0%, 3%, 6%, 9% (w/v)) pH (5.0, 6.0, 7.0, 8.0). probability models were built using logistic regression. For adhesion, only terms linear T are significant (p < 0.05), whereas T, NaCl,...
Purpose: To improve the solubility and bioavailability of atorvastatin calcium (ATC), a poorly watersoluble 3-hydroxy 3-methyl glutaryl CoA (HMG-CoA) reductase inhibitor, by solid dispersion technique using polyethylene glycol 6000 (PEG 6000) or polyvinylpyrrolidone k30 (PVP K30).Methods: The dispersions were characterised differential scanning calorimetry (DSC), powder x-ray diffraction (PXRD) Fourier transformed infrared (FT-IR) spectroscopy. dissolution characteristics formulations...
Vascular endothelial growth factor and its tyrosine kinase receptors have been identified as key mediators of the regulation pathologic blood vessel maintenance in promotion angiogenesis tumor growth. Therefore, an alternative approach to destroying endothelium would be make this tissue particularly sensitive VEGF-mediated drug delivery. To verify hypothesis, we generated a protein containing VEGF165 fused melittin. Melittin is small linear peptide composed 26 amino acid residues that can...
MDR1 encodes an adenosine triphosphate (ATP)-dependent efflux transporter that protects the body from environmental xenobiotics to maintain optimal health. Five single nucleotide polymorphisms (SNPs) of MDR1, T-2410C, T-129C, C1236T, G2677T/A and C3435T, were identified in our previous study. To investigate further biological significance these SNPs, we genotyped SNPs 135 patients with diffuse large B-cell lymphoma (DLBCL) 376 age- sex-matched controls. Statistical analysis indicated...
The aim of this study was to design a chitosan-coated hollow tin dioxide nanosphere (CS-HSn) for loading febuxostat (FEB) using an adsorption method obtain sustained-release system (CS-HSn-FEB) improve the oral bioavailability FEB. morphological characteristics nanospheres (HSn) and CS-HSn were analyzed by transmission electron microscopy (TEM) dynamic light scattering (DLS). hemolysis test CCK-8 used assess biosafety HSn CS-HSn. Powder X-ray diffraction (PXRD) differential scanning thermal...
In this study, we prepared PTX-loaded mesoporous hollow SnO 2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a structure. The average outer diameter was 200 nm, the wall thickness 50 nm. DSC XRD study that PTX in channels of present an amorphous state. vitro release experiments demonstrated could efficiently improve dissolution rate PTX. Both cell vivo antitumor SFNFP inhibit growth cells. Therefore, is promising...