A5100776889- Drug Transport and Resistance Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Phytochemicals and Antioxidant Activities
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Agriculture, Soil, Plant Science
- MicroRNA in disease regulation
- Attachment and Relationship Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Effects and Toxicity Studies
- Cancer Cells and Metastasis
- Ion Channels and Receptors
- Helicobacter pylori-related gastroenterology studies
- Liver physiology and pathology
- Music Therapy and Health
- Environmental Policies and Emissions
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Energy and Environmental Systems
- Marine and Coastal Research
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- Maternal and Perinatal Health Interventions
- Olfactory and Sensory Function Studies
- Gastrointestinal motility and disorders
Korea Institute for International Economic Policy
2014-2023
University of California, Los Angeles
2012-2020
EuBiologics (South Korea)
2018
Seoul National University Hospital
2017
Korea Rural Economic Institute
2016
Kyungpook National University
2015-2016
Chung-Ang University
2016
Korea University
2016
Yonsei University
1995-2015
Wonkwang University
2004-2013
Multidrug resistance protein 2 (MRP2, ABCC2) is involved in the transport of antiepileptic drugs and upregulated brain tissues patients with epilepsy. Therefore, genetic variations MRP2 gene may affect individual drug responses to agent carbamazepine.Associations between polymorphisms adverse reactions (ADRs) carbamazepine were analyzed using an integrated population genetics molecular functional approach. In initial case-control study, five tag single nucleotide 146 Patients divided into...
Atopy or atopic syndrome is an allergic hypersensitivity subject to hereditary influences. Aberrant expression of chitinase 3-like 1 (CHI3L1), also known as YKL-40 HC gp-39, involved in the pathogenesis inflammatory and diseases.The genetic contribution CHI3L1 gene susceptibility was investigated using integrated population molecular analysis.Genetic variations were identified genotyped 295 unrelated patients with atopy 180 control subjects. Serum IgE levels analyzed according genotype. The...
Cancer stem cells (CSCs) are defined as a small subpopulation of cancer within tumor and responsible for initiation maintenance growth. Thus, understanding molecular regulators CSCs is paramount importance the development effective therapies. Here, we identified jumonji domain-containing protein 6 (JMJD6) novel regulator oral CSCs. JMJD6 highly expressed in CSC-enriched populations human squamous cell carcinoma (OSCC) lines. Moreover, immunohistochemical staining revealed significantly high...
// Sung Hee Lee 1 , Nicole Kristina Rigas Chang-Ryul April Bang Sonal Srikanth 2 Yousang Gwack Mo K. Kang 1,3 Reuben H. Kim No-Hee Park 1,3,4 and Ki-Hyuk Shin The Shapiro Family Laboratory of Viral Oncology Aging Research, UCLA School Dentistry, Los Angeles, CA, USA Department Physiology, David Geffen Medicine at UCLA, 3 Jonsson Comprehensive Cancer Center, 4 Medicine, Correspondence to: Shin, email: Keywords : Orai1, OSCC, cancer stem cells, NFAT, SOCE Received May 20, 2016 Accepted 26,...
Objectives To compare tinnitus patients who have normal hearing between 250 Hz and 8 kHz with controls regard to the ability of each group hear extended high-frequency pure tone thresholds. Methods We enrolled 18 patients, whom had a threshold HL <25 dB differences <10 ears at frequencies 500 1, 2, 4, kHz. also age- gender-matched volunteers (10 ears), for patient. Extended high frequency audiometry was performed, mean thresholds 10, 12, 14, 16 ear were compared those 10 sex-matched ears....
High-risk human papillomaviruses (e.g., HPV16, HPV18) are closely associated with the development of head and neck cancers including oral/oropharyngeal squamous cell carcinoma (OSCC). We previously demonstrated immortalization normal oral keratinocytes by introducing high-risk HPV whole genome, suggesting that infection plays an important role in early stage carcinogenesis. Although may occur different stages cancer development, roles exacerbating malignant phenotypes already-transformed...
We investigated whether the 2677G>T/A and 3435C>T polymorphisms of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) affect efficacy ondansetron to prevent postoperative nausea vomiting. One hundred ninety-eight patients undergoing general anaesthesia were enrolled. Thirty minutes before end surgery, 0.1 mg.kg⁻¹ was administered intravenously. The incidence vomiting compared between genotypes in ABCB1. lower with 2677TT genotype (TT vs Non-TT = 25.9% 53.0%, p 0.01) 3435TT...
In the present study, we investigated whether speech-related cognitive function and speech recognition ability under background noise in adults with hearing impairment are improved use of aids.Participants were recruited from ENT Department Eulji Hospital September 2008 to July 2009. The study group comprised 18 participants (mean age, 69.5±8.3 years) sensorineural loss who fitted aids, control 11 equivalent age 63.1±11.8 not aids. All assessed using computerized Korean visual verbal...
Periodontitis is a local and systemic inflammatory condition risk factor of atherosclerosis, but no studies investigated the effect statin on atherogenesis affected by severe periodontitis. In this study, we rosuvastatin (RSV) in Apolipoprotein E-deficient mice receiving silk ligature placement around maxillary second molars. Mice with developed periodontitis vascular inflammation. RSV significantly inhibited development inflammation remarkably blocked increased lipid deposition atherogenic...
Multidrug resistance protein 1 (MRP1, ABCC1) transports antidepressive agents in the endothelial cells of blood-brain barrier. Therefore, polymorphisms MRP1 gene may affect treatment response antidepressants. This study was aimed to identify association between genetic variations MRP1/ABCC1 and therapeutic antidepressant citalopram. One hundred twenty-three patients who had been treated with citalopram monotherapy control their major depressive disorder were recruited, genotype data from 64...
Nuclear factor of activated T cells (NFATc1-c4), a family transcription factors, is involved in many biological processes by regulating various downstream target genes. However, their role cancer progression remains controversial. We here report that NFATc3 the dominant isoform NFAT human oral epithelial cells, and its expression was increased stepwise manner during oral/oropharyngeal squamous cell carcinoma (OSCC). More importantly, highly enriched self-renewing stem-like (CSCs) OSCC....
Abstract High-risk human papillomaviruses (HPVs) are involved in the development of several cancers, including oropharyngeal squamous cell carcinomas. However, many studies have demonstrated that HPV alone is not sufficient for oncogenic transformation normal epithelial cells, indicating additional cofactors required conversion HPV-infected cells. Inasmuch as chronic inflammation also closely associated with carcinogenesis, we investigated effect exposure to tumor necrosis factor α (TNFα),...