A5071177256- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- DNA Repair Mechanisms
- Cell death mechanisms and regulation
- Heat shock proteins research
- DNA and Nucleic Acid Chemistry
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- PARP inhibition in cancer therapy
- NF-κB Signaling Pathways
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- ATP Synthase and ATPases Research
- Hair Growth and Disorders
- Antioxidant Activity and Oxidative Stress
- Dermatology and Skin Diseases
- Alzheimer's disease research and treatments
- Cardiac Fibrosis and Remodeling
- Advanced Glycation End Products research
- Chemotherapy-induced cardiotoxicity and mitigation
- Fatty Acid Research and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- RNA modifications and cancer
- Cancer therapeutics and mechanisms
Yonsei University
2005-2023
CHA University
2014-2023
Cardiovascular Institute Hospital
2012-2023
Gangnam Severance Hospital
2023
Bioscience (China)
2023
Life University
2021
Government of the Republic of Korea
2021
CHA Bundang Medical Center
2020
Sangmyung University
2020
Bridge University
2020
Bone marrow mesenchymal stem cells (MSCs) have shown potential for cardiac repair following myocardial injury, but this approach is limited by their poor viability after transplantation. To reduce cell loss transplantation, we introduced the fibroblast growth factor-2 (FGF-2) gene ex vivo before The isolated MSCs produced colonies with a fibroblast-like morphology in 2 weeks; over 95% expressed CD71, and 28% cardiomyocyte-specific transcription factor, Nkx2.5, as well α-skeletal actin,...
Abstract Mesenchymal stem cell (MSC) therapy for myocardial injury has inherent limitations due to the poor viability of MSCs after transplantation. In this study, we directly delivered Hsp70, a protein with protective functions against stress, into MSCs, using Hph-1 transduction domain ex vivo high transfection efficiency and low cytotoxicity. Compared control in vitro hypoxic conditions, Hph-1-Hsp70 (Hph-1-Hsp70-MSCs) displayed higher anti-apoptotic properties, including Bcl2 increase,...
Meteorin-like (metrnl) is a recently identified adipomyokine that beneficially affects glucose metabolism; however, its underlying mechanism of action not completely understood. We here show the level metrnl increases in vitro under electrical pulse stimulation and vivo exercised mice, suggesting secreted during muscle contractions. In addition, uptake via calcium-dependent AMPKα2 pathway skeletal cells phosphorylation HDAC5, transcriptional repressor GLUT4, an AMPKα2-dependent manner....
Transcriptional factor nuclear factor-kappaB (NF-κB) plays a crucial role in human breast cancer cell invasion and metastasis. The carboxyl terminus of Hsc70-interacting protein (CHIP) is U-box-type ubiquitin ligase that induces ubiquitination proteasomal degradation its substrate proteins. In this study, we investigated the CHIP NF-κB pathway MDA-MB-231 cells, highly aggressive line. We showed overexpression significantly inhibits cells. suppressed expression urokinase plasminogen activator...
Quercetin, an abundant flavonol found in fruits and vegetable, has been implicated lowering the risk of cardiovascular disease that is often associated with high plasma levels low density lipoprotein (LDL) cholesterol. Here we investigated whether quercetin could modulate expression LDL receptors (LDLR) HepG2 cells possible underlying mechanisms to exert quercetin's effects. We was able induce LDLR at least a 75 µ m concentration, which accompanied by increase nuclear sterol regulatory...
Insulin inhibits ischemia/reperfusion-induced myocardial apoptosis through the PI3K/Akt/mTOR pathway. Survivin is a key regulator of anti-apoptosis against doxorubicin-induced cardiotoxicity. increases survivin expression in cardiac myocytes to mediate cytoprotection. However, mechanism by which mediates protective effect insulin doxorubicin-associated injury remains be determined. In this study, we demonstrated that pretreatment H9c2 with resulted significant decrease apoptotic cell death...
Lysophosphatidylcholine (lysoPC) induces vascular smooth muscle cell (VSMC) proliferation and migration, which has been proposed to initiate the intimal thickening in coronary atherosclerotic lesions. Berberine is an alkaloid Berberis aquifolium many other plants. Recently, it shown have beneficial effects on cardiovascular system, such as anti-hyperglycemic cholesterol-lowering activity. In this study, we investigated its lysoPC-induced VSMC migration. inhibited DNA synthesis VSMCs, well...
Velocity-vector imaging (VVI) represents a valuable new method for noninvasive quantification of vascular properties associated with aging. The purpose this study was to assess the correlations between VVI parameters and histological changes aging.Fourteen mongrel dogs were classified as either young (n=7; age, 1-2 years; female; weighing 22-29 kg) or senescent 8-12 36-45 kg). short-axis image descending thoracic aorta obtained analysis transesophageal echocardiography. location identified...
Heat shock protein 90 (HSP90), one of the most abundant proteins in cardiac cells is essential for cell survival. Previous studies have shown that angiotensin II induces hypertrophy. However, role HSP90 II-induced hypertrophy unclear. In this study, we showed regulated via maintenance IκB kinase (IKK) complex stability cells. An inhibitor, geldanamycin (GA), significantly suppressed [3H]leucine incorporation and atrial natriuretic factor expression GA also inhibited NF-κB activation induced...