A5100693208- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Single-cell and spatial transcriptomics
- Inflammasome and immune disorders
- Higher Education and Teaching Methods
- Glycosylation and Glycoproteins Research
- Innovative Educational Techniques
- Pain Mechanisms and Treatments
- Immune cells in cancer
- Microbial Metabolic Engineering and Bioproduction
- Metabolism, Diabetes, and Cancer
- Photonic and Optical Devices
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Ideological and Political Education
Wuhan Ship Development & Design Institute
2025
Nantong University
2017-2025
Affiliated Hospital of Jining Medical University
2024-2025
Anhui University
2013-2025
First Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Affiliated Hospital of Nantong University
2020-2025
Affiliated Hospital of Qingdao University
2021-2024
Zhejiang Ocean University
2023-2024
Harbin Normal University
2024
The molecular mechanism underlying brain regeneration in vertebrates remains elusive. We performed spatial enhanced resolution omics sequencing (Stereo-seq) to capture spatially resolved single-cell transcriptomes of axolotl telencephalon sections during development and regeneration. Annotated cell types exhibited distinct distribution, features, functions. identified an injury-induced ependymoglial cluster at the wound site as a progenitor population for potential replenishment lost...
Abstract Spatial transcriptomics measures in situ gene expression at millions of locations within a tissue 1 , hitherto with some trade-off between transcriptome depth, spatial resolution and sample size 2 . Although integration image-based segmentation has enabled impactful work this context, it is limited by imaging quality heterogeneity. By contrast, recent array-based technologies offer the ability to measure entire subcellular across large samples 3–6 Presently, there exist no...
Heart failure with preserved ejection fraction (HFpEF) is a difficult disease high morbidity and mortality rates lacks an effective treatment. Here, we report the therapeutic effect of dapagliflozin, sodium-glucose cotransporter 2 inhibitor (SGLT2i), on hypertension + hyperlipidemia-induced HFpEF in pig model. pigs were established by infusing combination deoxycorticosterone acetate (DOCA) angiotensin II (Ang II), Western diet (WD) feeding for 18 weeks. In 9th week, half randomly assigned to...
Aging is a risk factor for many human pathologies and characterized by extensive metabolic changes. Using targeted high-throughput metabolite profiling in Drosophila melanogaster at different ages, we demonstrate that methionine metabolism changes strikingly during aging. Methionine generates the methyl donor S-adenosyl-methionine (SAM), which converted via methylation to S-adenosyl-homocysteine (SAH), accumulates A RNAi screen against pathway components revealed significant life span...
Mesenchymal stem cells (MSCs) have been demonstrated to be involved in tumor progression and the modulation of microenvironment, partly through their secretome. Extracellular vesicles (EVs) are membranous nanovesicles secreted by multiple types mediate intercellular communication both physiological pathological conditions. However, numerous questions still remain regarding underlying mechanisms functional consequences these interactions. The purpose this study was investigate effects human...
Brain and muscle arnt-like protein 1 (Bmal1) is a crucial transcription factor, regulating circadian rhythm involved in multiple heart diseases. However, it unknown whether Bmal1 promotes diabetic cardiomyopathy (DCM) pathogenesis. The objective of this investigation was to ascertain the vital role progression DCM. Mice with T2D H9c2 cardiomyoblasts exposed high glucose palmitic acid (HGHP) were used. Cardiomyocyte-specific knockout mouse (CKB) also generated, cardiac overexpressed type 2...
Abstract Epilepsy is a network disorder, involving neural circuits at both the micro- and macroscale. While local excitatory-inhibitory imbalances are recognized as hallmark microscale, dynamic role of distinct neuron types during seizures remain poorly understood. At macroscale, interactions between key nodes within epileptic network, such central median thalamic nucleus (CMT), critical to the, hippocampal process. However, precise mechanisms underlying these unclear. In this study, we...
Globally, liver cancer has the third highest mortality rate among all types of due to invasive and metastatic capacities tumor cells. MicroRNA (miR) is a class non-coding RNAs that participate in development cancer. The aim present study was explore molecular mechanisms by which miR-221-3p miR-15b-5p promote proliferation invasion cells through targeting axis formation inhibitor 2 (Axin2) identify suitable targets for treatment expression levels were determined tissues quantitative PCR,...
An improved achromatic holographic waveguide display system with high efficiency is proposed, which composed of an in-coupled planar hologram and outcoupled volume hologram. The improved, compared the previous proposed by Shi et al. (Appl. Opt.51, 4703–4078 [2012]10.1364/AO.51.004703APOPAI1559-128X), loss resulting from multiple exposures reduced combination basic idea principles are described, experiments performed. experimental results demonstrate that can achieve higher diffraction reduce...
ε-Polylysine (ε-PL) was studied for the growth inhibition of Shewanella putrefaciens (S. putrefaciens). The minimal inhibitory concentration (MIC) ε-PL against S. measured by broth dilution method, while membrane permeability and metabolism were assessed after treatment. Additionally, curves, content alkaline phosphatase (AKP), electrical conductivity (EC), UV absorbance scanning electron microscope (SEM) data used to study cellular morphology. impact on cell also investigated different...
// Juan Wang 1 , Guomu Liu Qiongshu Li Fang Fei Xie Ruiping Zhai Yingying Guo Tanxiu Chen Nannan Zhang Weihua Ni Hongyan Yuan and Guixiang Tai Department of Immunology, College Basic Medical Science, Jilin University, Changchun, China Correspondence to: Tai, email: Keywords : Mucin1, HCC, JNK, TGF-β, Smad2L/C Received March 20, 2015 Accepted May 13, Published 25, Abstract Mucin1 (MUC1), as an oncogene, plays a key role in the progression tumorigenesis many human adenocarcinomas. In this...
Previous studies have investigated heavy metal exposure could increase the occurrence of congenital heart defects (CHDs). However, there are limited data regarding relationship between to nickel and CHDs in offspring. The aim this study was analyze association mothers risk offspring.To explore CHD, a case-control with 490 controls 399 cases China were developed. concentrations hair pregnant woman fetal placental tissue measured used logistic regression analysis CHD.The median 0.629 ng/mg, P...