A5101545179- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Advancements in Battery Materials
- RNA Research and Splicing
- Advanced Battery Materials and Technologies
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
- Advanced Battery Technologies Research
- Protease and Inhibitor Mechanisms
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- CRISPR and Genetic Engineering
- Spondyloarthritis Studies and Treatments
- S100 Proteins and Annexins
- RNA modifications and cancer
- Vibrio bacteria research studies
Xi'an Jiaotong University
2016-2025
Royal College of Surgeons in Ireland
2025
Jiangsu Vocational College of Medicine
2025
Xi'an Honghui Hospital
2018-2025
First Hospital of Shanxi Medical University
2018-2024
Shanxi Medical University
2018-2024
Harbin Institute of Technology
2024
Ningxia University
2024
First Affiliated Hospital of Kunming Medical University
2017-2023
Kunming Medical University
2017-2023
Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy circular RNAs (circRNAs) play critical roles cancer progression chemoresistance. However, function mechanism of circRNA autophagy regulation LSCC remain unclear. The autophagy-suppressive circPARD3 was identified via RNA sequencing 107 tissues paired adjacent normal mucosal (ANM) high-content screening. RT-PCR, Sanger sequencing, qPCR fluorescence situ hybridization were performed...
Graphite has been serving as the key anode material of rechargeable Li-ion batteries, yet is difficultly charged within a quarter hour while maintaining stable electrochemistry. In addition to defective edge structure that prevents fast entry, high-rate performance graphite could be hampered by co-intercalation and parasitic reduction solvent molecules at anode/electrolyte interface. Conventional surface modification pitch-derived carbon barely isolates electrons, usually lead inadequate...
Abstract Background Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck. LSCC patients have seriously impaired vocal, respiratory, swallowing functions with poor prognosis. Circular RNA (circRNA) has attracted great attention in cancer research. However, expression patterns roles circRNAs remain largely unknown. Methods sequencing was performed on 57 pairs matched adjacent normal mucosa tissues to construct circRNA, miRNA, mRNA profiles. RT-PCR, qPCR,...
Laryngeal squamous cell carcinoma (LSCC) is a common form of head and neck cancer with poor prognosis. However, the mechanism underlying pathogenesis LSCC remains unclear. Here, we demonstrated increased expression fascin actin-bundling protein 1 (FSCN1) decreased microRNA-145-5p (miR-145-5p) in clinical cohort LSCC. Luciferase assay revealed that miR-145-5p negative regulator FSCN1. Importantly, low was correlated TNM (tumor, node, metastasis) status metastasis. Moreover, cases...
Abstract Chemokines, cytokines, and inflammatory cells mediate the onset progression of many diseases through induction an response. LncRNAs have emerged as important regulators gene expression signaling pathways. Increasing evidence suggests that lncRNAs are key players in response, making it a potential therapeutic target for various diseases. From perspective factors, we summarized level regulatory mechanisms human diseases, such cardiovascular disease, osteoarthritis, sepsis, chronic...
Abstract Graphite has been serving as the key anode material of rechargeable Li‐ion batteries, yet is difficultly charged within a quarter hour while maintaining stable electrochemistry. In addition to defective edge structure that prevents fast entry, high‐rate performance graphite could be hampered by co‐intercalation and parasitic reduction solvent molecules at anode/electrolyte interface. Conventional surface modification pitch‐derived carbon barely isolates electrons, usually lead...
Spindle and kinetochore-associated complex subunit 3 (SKA3) is a well-known regulator of chromosome separation cell division, which plays an important role in proliferation. However, the mechanism SKA3 regulating tumor proliferation via reprogramming metabolism unknown. Here, identified as oncogene laryngeal squamous carcinoma (LSCC), high levels are closely associated with malignant progression poor prognosis. In vitro vivo experiments demonstrate that promotes LSCC chemoresistance through...
Abstract Bacteroides fragilis, one of the potential next-generation probiotics, but its protective mechanism is not yet known. We aimed to characterize anti-inflammatory effect B. fragilis ATCC25285 and elucidate through in vivo vitro experiments. An model inflammation by induction colonic cells with TNF-a, co-cultured detect cell viability, apoptosis invasive capacity. Furthermore, critical proteins TLR/NF-κB pathway inflammatory cytokines were measured. For animal trials, C57BL/6 J male...
About one-third of breast cancers express a functional estrogen (beta-estradiol [E2]) receptor (ER) and are initially dependent on E2 for growth survival but eventually progress to hormone independence. We show here that ER(+), E2-independent MCF-7/LCC1 cells derived from E2-dependent MCF-7 contain elevated basal NF-kappaB activity expression the transcriptional coactivator Bcl-3 compared with parental line. LCC1 consists primarily p50 dimers, although low levels p65/p50 complex also...
Background: Recent studies revealed that miR-424-5p regulates the malignant behavior of multiple cancer types. However, expression and function in laryngeal squamous cell carcinoma (LSCC) is unclear. Purpose: This study aimed to evaluate association level with clinical features LSCC investigate effect potential mechanism on progression. Methods: The paired adjacent normal margin (ANM) tissues from 106 patients were analyzed by quantitative PCR (qPCR), significance was analyzed. Target genes...
At present, no blood-based biomarkers have been used in clinical practice for laryngeal squamous cell carcinoma (LSCC). Increasing evidence suggests that circulating exosomal microRNAs (miRNAs) may serve as potential diagnostic various cancers. This study aims to identify and evaluate serum miRNAs LSCC diagnosis. The ExoQuick solution (EQ), which provides a high-yield is highly efficient exosome isolation method, was selected isolate exosomes the current study. In samples, concentrations...
CD133+CD44+ cancer stem cells previously isolated from laryngeal squamous cell carcinoma (LSCC) lines showed strong malignancy and tumorigenicity. However, the molecular mechanism underlying enhanced remained unclear.Cell proliferation assay, spheroid-formation experiment, RNA sequencing (RNA-seq), miRNA-seq, bioinformatic analysis, quantitative real-time PCR, migration invasion luciferase reporter assay were used to identify differentially expressed mRNAs, lncRNAs, circRNAs miRNAs,...
Abstract Background Colorectal adenomatous polyps (CAPs) are considered precancerous lesions of colorectal cancer (CRC). The gut microbiota participates in the process digestion and, process, produces metabolites, mainly short-chain fatty acids (SCFAs), secondary bile and conjugated linoleic acid (CLA). This study aimed to investigate constituents metabolites faeces CAP patients identify or that can be used as sensitive biological predictors provide a theoretical basis for clinical treatment...
Polymer-derived silicon oxycarbide (SiOC) composites have recently attracted considerable attention because of their potential as high capacity electrode for rechargeable lithium ion batteries.
This study explored the proteomic landscape of inflammatory protein dysregulation in ankylosing spondylitis (AS), a chronic disorder primarily affecting axial skeleton and strongly associated with HLA-B27 allele, particularly HLA-B2705 HLA-B2704 subtypes prevalent Chinese populations. Blood samples from HLA-B27-positive AS patients normal controls (NC) were analyzed using Olink Target 96 inflammation panel to profile 92 proteins. subtyping was performed via PCR-SSP. To identify key proteins...
With the detection rate increasing each year, highly resistant and virulent CRKP has been a serious challenge to clinical treatment because of high morbidity mortality. Considering virulence is closely related over-expression siderophore, entB ybtS genes in may be an important reason for phenotype CRKP. Therefore, this study, single/double knockout complemented strains siderophore were constructed clarify effect on CRKP.1.The wire drawing experiment, mucus screening PCR amplification used...
Dysregulation of fascin actin-bundling protein 1 (FSCN1) enhances cell proliferation, invasion, and motility in laryngeal squamous carcinoma (LSCC), while the mechanism remains unclear. Here, co-immunoprecipitation mass spectrometry is utilized to identify potential FSCN1-binding proteins. Functional annotation proteins are performed by Gene Ontology Kyoto Encyclopedia Genes Genomes pathway analysis. Furthermore, protein-protein interaction network FSNC1-binding constructed interactions...
// Xin-Xing Zhu 1, 2, * , Ya-Wei Yan Chun-Zhi Ai 1 Shan Jiang Shan-Shan Xu Min Niu 3 Xiang-Zhen Wang 4 Gen-Shen Zhong 5 Xi-Feng Lu 6 Yu Xue 7 Shaoqi Tian 8 Guangyao Li 9 Shaojun Tang 10 Yi-Zhou Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, China 2 Key Laboratory of Optoelectronic Devices and Systems Ministry Education College Engineering, Department Statics, University Wisconsin-Madison, Madison, WI, USA Maternal Child Health Hospital Nanshan District, The First...
This study intends to investigate the transcriptional regulatory role of miR-145-5p in laryngeal squamous cell carcinoma (LSCC). LSCC line TU-177 is transfected with mimics, generating miR-145-5p-overexpression cells. Whole transcriptome microarrays are used differentially expressed lncRNAs, circRNAs, mRNAs, and miRNAs. The target genes miRNAs predicted performed functional annotation. Additionally, mRNAs that interact predicted, then competing endogenous RNAs (ceRNAs) predicted. Microarray...