A5101611380- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Viral Infections and Vectors
- Tissue Engineering and Regenerative Medicine
- Uterine Myomas and Treatments
- Cancer Cells and Metastasis
- Viral Infections and Outbreaks Research
- Hepatitis B Virus Studies
- Bioenergy crop production and management
- Advanced Computing and Algorithms
- Mesenchymal stem cell research
- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Erythrocyte Function and Pathophysiology
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Animal Virus Infections Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- E-commerce and Technology Innovations
- RNA modifications and cancer
Fudan University
2023-2025
Zhongshan Hospital
2024-2025
Xiangya Hospital Central South University
2019-2024
Central South University
2019-2024
Guangdong Academy of Medical Sciences
2019-2021
Guangdong Provincial People's Hospital
2019-2021
Shandong Agricultural University
2021
Zhangqiu City People's Hospital
2018-2020
Beijing University of Chinese Medicine
2017-2020
Emory University
2017-2019
Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis.
Background: Conventional methods for predicting treatment response to neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC) are limited. Methods: This study retrospectively recruited 134 LARC who underwent standard nCRT followed by total mesorectal excision surgery our institution. Based on pre-operative axial T2-weighted images, machine learning radiomics was performed. A receiver operating characteristic (ROC) curve performed test the efficiencies of...
Abstract Background Total mesorectal excision following neoadjuvant chemoradiotherapy (nCRT) is recommended in the latest treatment of locally advanced rectal cancer (LARC). Objective To predict whether patients with LARC can achieve pathologic complete response (pCR), comparing MRI‐based radiomics between before and after radiotherapy (nRT) was performed. Methods One hundred sixty‐five features axial T2‐weighted images were obtained quantitatively from Imaging Biomarker Explorer Software....
Abstract Miscanthus , a member of the Saccharinae subtribe that includes sorghum and sugarcane, has been widely studied as feedstock for cellulosic biofuel production. Here, we report sequencing assembly floridulus genome by integration PacBio Hi-C mapping, resulting in chromosome-scale, high-quality reference genus . Comparisons among genomes suggest Sorghum split first from common ancestor Saccharum which subsequently diverged each other, with two successive whole-genome duplication events...
Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) plays a vital role in the development of malignant tumors; however, its biological and underlying mechanism epithelial ovarian cancer (EOC) remain unclear. In this study, we aimed to investigate function clinical significance LGR5 human EOC. We evaluated expression EOC cell lines tissues from patients by qPCR, Western blotting, immunohistochemical analysis. Cell proliferation, colony formation, transwell invasion assay,...
The incidence of colorectal cancer in patients younger than 50 years has been increasing recent years.Develop and validate prognostic nomograms predicting overall survival (OS) cancer-specific (CSS) for early-onset locally advanced colon (EOLACC) based on the Surveillance, Epidemiology, End Results (SEER) database.The entire cohort comprised 13,755 with EOLACC. nomogram OS EOLACC displayed that T stage contributed most to prognosis, followed by N stage, regional nodes examined (RNE) surgery....
Previous studies reported that Follistatin-like 3 (FSTL3) is abundantly expressed in several solid tumors and participate the regulation of cell metabolism. However, clinico-pathological significance, biological role molecular mechanism FSTL3 colorectal cancer (CRC) still unclear. Here we report expression level colon specimens was significantly higher, compared to normal tissue interestingly, related lymph node metastasis, tumor stage, size, intravascular emboli (IVE). As an upstream event,...
N6-methyladenosine (m6A) modifications of RNAs are involved in various aspects colorectal carcinogenesis via regulation mRNA stability, splicing, and translation. KIAA1429, an m6A methyltransferase, was found deregulated multiple cancer types. However, its role remains elusive. By analyzing TCGA GEPIA database, we that KIAA1429 highly expressed. In addition, used immunohistochemistry, western blotting, QRT-PCR to detect the expression samples cell lines, overexpressed sample line....
Although cisplatin is frequently used to treat gastric cancer, the resistance main obstacle for effective treatment. mRNA modification, N6-methyladenosine (m6A), involved in tumorigenesis of many types cancer. As one largest m6A methyltransferase complex components, KIAA1429 bridges catalytic such as METTL3. In was reported promote cell proliferation. However, whether cancer remains unclear. Here, we generated resistant lines, and compared content between cells wild type cells. The well...
Intravenous leiomyomatosis (IVL) is a histologically well differentiated smooth muscle tumor with aggressive behavior, capable of extending throughout the venous system. Understanding how IVL occurs and develops really important for diagnosing treating it. Unfortunately, because quite rare, there aren't many comprehensive studies available. In our research, we carried out an extensive multi-omics study, gathering tissue samples from cases, uterine fibroid, normal myometrium. The single-cell...
There is no conclusion about the most important contributor to upswing of locally advanced colorectal cancer (LACRC) survival.Data from Surveillance, Epidemiology, and End Results (SEER) database was extracted identify adenocarcinoma patients at stage II III diagnosed in two periods 1989-1990 2009-2010. The statistical methods included Pearson's chi-squared test, log-rank Cox regression model propensity score matching.The showed that hazard ratio (HR) non-surgery dropped 11.529 3.469 right...
Background: Colorectal cancer (CRC) ranks as the third most frequent type and second leading cause of cancer-related death worldwide.The liver is common metastatic site CRC with 20%-34% patients suffering synchronous metastasis.Patients colorectal liver-limited metastasis account for one-third deaths from cancer.Moreover, some evidence indicated that disease encounter a worse prognosis more disseminated state comparing develops metachronously.Methods: Data in this retrospective analysis were...
Purpose: To identify the clinical predictive factors of tumor response and to evaluate significance primary gross volume (pGTV), obtained from radiotherapy planning, in predicting response. Materials Methods: We retrospectively analyzed data consecutive locally advanced rectal cancer (LARC) patients who were treated with neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery at our institution between March 2009 December 2017. independent predictors nCRT statistical analysis....
Background: Small intestine cancers, as an extremely rare tumor type, account only for 3% of all gastrointestinal tumors. adenocarcinoma (SIA), representing approximately one-third small bowel has received relatively little attention, both in research efforts and clinical cognizance. Owing to anatomical proximity rarity, adenocarcinomas are frequently grouped with colorectal adenocarcinomas. Therefore, a large SIA patient cohort is needed develop validate new nomogram prognostic models...
This study is aimed at investigating predictive and prognostic factors of synchronous colorectal lung-limited metastasis (SCLLM) based on The Surveillance, Epidemiology, End Results (SEER) database. A multivariate logistic regression model was constructed to identify independent predictors SCLLM. Cox proportional hazards used distinguish factors. enrolled 168,007 cancer (CRC) patients without metastatic diseases 1,298 cases with Eight features, involving race, tumor location, pathological...
Abstract Clinical reports on hepatotoxicity that arise from Rhizoma Paridis have recently received widespread attention. Because the mechanism is little understood, this research strived to investigate of extracts based iTRAQ quantitative proteomics and metabonomics. The extraction solutions were administrated rats for 7 days by gavage, was assessed through quantification biochemical indexes Oil red O staining. Additionally, investigated metabonomics upon GC-MS proteomics. histopathological...
Abnormal cell proliferation and invasion of vascular smooth muscle cells are among the primary causes cardiovascular disease. Studies have shown that microRNA(miR)‑342‑5p participates in development diseases. The current study aimed to explore role miR‑342‑5p differentiation mouse aortic (MOVAS) cells. MOVAS were transfected with mimics, inhibitor or their respective negative controls, co‑transfected small interfering (si)RNA targeting phosphatidylinositol 3‑kinase regulatory subunit α...
Background: Rectal cancer accounts for approximately 30–50% of colorectal cancer. Despite its widespread use and convenience, the American Joint Committee on Cancer (AJCC) staging system predicting survival is prone to inaccuracy, even including a paradox locally advanced rectal (LARC). An accurate risk stratification LARC essential proper treatment selection prognostic evaluation. Therefore, we aimed create nomograms capable assessing overall (OS) cancer-specific (CSS) precisely intuitively.
SUMMARY North Korea conducted sixth underground nuclear test on 3 September 2017. Unlike its previous tests, a rare subsequent collapse event occurred after about 8.5 min. As two types of distinctive shallow seismic events, accurate inversion their focal mechanisms is important for identification CTBT. In this paper, we carry out moment tensor the and with gCAP using waveform data from dense regional stations. And are further constrained surface wave amplitude ratio. The results show that...
Total mesorectal excision (TME), chemotherapy (CT), and radiotherapy (RT) are usually integrated into the comprehensive treatment of stage II/III rectal cancer (RC). Neoadjuvant (nRT) has become standard for RC patients to help reduce size a tumor or kill cells that have spread. Adjuvant RT is delivered after resection destroy remaining used mainly in who not received preoperative radiotherapy, such as those suffered from bowel obstruction before surgery. It controversial whether can improve...
BACKGROUND Despite recent advancements in surgical techniques, chemotherapy, and radiotherapy, the 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) remains an unsatisfactory ~8%. MATERIAL AND METHODS Data were extracted to identify non-metastatic diagnosed periods 1988-1996 2010-2014 Surveillance, Epidemiology, End Results (SEER) database. The statistical analyses performed log-rank test, Pearson's chi-square propensity score matching, Cox regression model....
Background: Chemotherapy is suggested to use in all stages of pancreatic cancer. Is it reasonable recommend chemotherapy for PDAC patients? It necessary distinguish low-risk patients underwent pancreatectomy, who may not lose survival time due missed and need endure pain, nausea, tiredness, drowsiness, breath shortness caused by chemotherapy. Methods: Nomograms were constructed with basis from the multivariate Cox regression analysis. X-tile software was utilized perform risk stratification....