A5100398504- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Glycosylation and Glycoproteins Research
- Reproductive System and Pregnancy
- Advanced Vision and Imaging
- Glioma Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Occupational and environmental lung diseases
- Pregnancy and preeclampsia studies
- Computer Graphics and Visualization Techniques
- RNA Interference and Gene Delivery
- Sperm and Testicular Function
- Piezoelectric Actuators and Control
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Cancer Research and Treatments
- X-ray Diffraction in Crystallography
- RNA Research and Splicing
- Virus-based gene therapy research
- Lung Cancer Research Studies
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- 3D Shape Modeling and Analysis
- Renal and related cancers
- Neutropenia and Cancer Infections
Children's Hospital of Chongqing Medical University
2022-2025
Chongqing Medical University
2022-2025
West China Medical Center of Sichuan University
2003-2025
Guangxi Medical University
2022-2025
Beijing Ditan Hospital
2023-2025
Capital Medical University
2022-2025
Jinan University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Kunming Medical University
2025
Northwestern Polytechnical University
2025
Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis.
Purple corn anthocyanins are important natural colourants with cheap prices and rich bioactivities. However, their stability is limited. Microencapsulation an effective way to improve anthocyanin the influence of type wall material on encapsulated very important. In this study, maltodextrin (MD) its combination whey protein isolate (WPI) or gum arabic (GA) were utilised as materials obtain purple (PCAs) (MD-PCA, MD-WPI-PCA, MD-GA-PCA) using spray drying. The effect amount was determined by...
Abstract With the continuous development of human life and society, medical field is constantly improving. However, modern medicine still faces many limitations, including challenging previously unsolvable problems. In these cases, artificial intelligence (AI) can provide solutions. The research application generative adversarial networks (GAN) are a clear example. While most researchers focus on image augmentation, there few one-dimensional data augmentation examples. radiomics feature...
During cancer progression, tumorigenic and immune signals are spread through circulating molecules, such as cell-free DNA (cfDNA) RNA (cfRNA) in the blood. So far, they have not been comprehensively investigated gastrointestinal cancers. Here, we profile 4 categories of omics data from patients with colorectal stomach adenocarcinoma then assay 15 types genomic, epigenomic, transcriptomic variations. We find that multi-omics more appropriate for detection genes compared single-omics data. In...
Abstract Aim To explore the trajectories of consciousness recovery and prognosis‐associated predictors in children with prolonged disorder (pDoC). Method This single‐centre, retrospective, observational cohort involved 134 (87 males, 47 females) diagnosed pDoC hospitalized at Department Rehabilitation Children's Hospital Chongqing Medical University China. The median onset age was 30 (interquartile range [IQR] 18–54) months, ages ranging from 3 to 164 months. Least absolute shrinkage...
Establishment of adequate levels sialylation is crucial for sperm survival and function after insemination; however, the mechanism addition sialome has not been identified. Here, we report evidence several different mechanisms that contribute to establishment mature sialome. Directly quantifying source nucleotide sugar CMP-beta-N-acetylneuraminic acid in epididymal fluid indicates transsialylation occurs upper epididymis. Western blots low-molecular-mass sialoglycoprotein (around 20-50 kDa)...
Thyroid function has a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential associated thyroid function. We aimed to assess relationship among them using data from National Health and Nutrition Examination Survey (NHANES). This study was cross-sectional study, where weighted multivariable linear regression, subgroup analyses, interaction terms were employed. assessed by eight indexes, including total free T4 T3, Tg, TgAb, TPOAb, TSH. A of 2346...
Abstract Background Histone deacetylases (HDACs) have been shown to be involved in tumorigenesis, but their precise role and molecular mechanisms gastric cancer (GC) not yet fully elucidated. Methods Bioinformatics screening analysis, qRT-PCR, immunohistochemistry (IHC) were used identify the expression of HDAC4 GC. In vitro vivo functional assays illustrated biological function HDAC4. RNA-seq, GSEA pathway western blot revealed that activated p38 MAPK signalling. Immunofluorescence, blot,...
Colorectal cancer (CRC) is a common malignancy worldwide, and chronic stress has been considered as significant risk factor for CRC.However, the role of in CRC progression unclear.The present study showed that pre-exposure to facilitated tumor growth mice, epinephrine promoted cell proliferation vitro.Metabolomics analysis revealed reshaped metabolic pathways enhance glycolysis.Additional studies have shown enhanced expression levels glycolytic-associated enzymes, including GLUT1, HK2...
Leaf senescence is an orderly and highly coordinated process, finely regulated by ethylene nitrogen (N), ultimately affecting grain yield nitrogen-use efficiency (NUE). However, the underlying regulatory mechanisms on crosstalk between ethylene- N-regulated leaf remain a mystery in maize. In this study, biosynthesis gene ZmACS7 overexpressing (OE-ZmACS7) plants were used to study role of regulating response N deficiency, they exhibited premature accompanied increased release, decreased...
Mutations in human angiogenin (hANG), an angiogenic member of the RNase A superfamily, have been recently reported patients with amyotrophic lateral sclerosis (ALS), a progressive late-onset neurodegenerative disorder. However, very little is known about expression and subcellular distribution ANG nervous system or its role differentiation. Here we report that mouse angiogenin-1 (mAng-1) strongly expressed developing during embryogenesis neuroectodermal differentiation pluripotent P19...
Oxidation states (OS) are the charges on atoms due to electrons gained or lost upon applying an ionic approximation their bonds. As a fundamental property, OS has been widely used in charge-neutrality verification, crystal structure determination, and reaction estimation. Currently, only heuristic rules exist for guessing oxidation of given compound with many exceptions. Recent work developed machine learning models based structural features predicting metal ions. However, composition-based...