A5101579290- Immune cells in cancer
- Gallbladder and Bile Duct Disorders
- Nutrition and Health in Aging
- Immune Response and Inflammation
- Clinical Nutrition and Gastroenterology
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Cardiac Health and Mental Health
- Cardiac Arrest and Resuscitation
- Inflammation biomarkers and pathways
- Obesity, Physical Activity, Diet
- Respiratory Support and Mechanisms
- NF-κB Signaling Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sirtuins and Resveratrol in Medicine
- IL-33, ST2, and ILC Pathways
- Hydrogen's biological and therapeutic effects
- Liver Diseases and Immunity
- Biliary and Gastrointestinal Fistulas
- Muscle and Compartmental Disorders
- Complementary and Alternative Medicine Studies
- Traditional Chinese Medicine Analysis
Chongqing Medical University
2013-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2013-2025
Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis.
Abstract Background Previous cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficiently powered study is therefore warranted to ascertain effects guideline implementation on patient-centered outcomes. Methods We conducted a multicenter, cluster-randomized, parallel-controlled trial intensive care units (ICUs) across China. developed...
The impairment of immunity characterized by T cell exhaustion is the main cause death in patients with sepsis after acute phase. Although PD-1 blockade highly touted as a promising treatment for improving prognosis, actual results are not satisfactory mice model. A recent study revealed LAG3 can resist therapeutic effect tumor, which inspired us to understand their role sepsis. We enrolled 26 from 422 candidates using strict inclusion criteria. Follow-up analysis that expression levels were...
Overwhelming inflammation and extensive alveolar-endothelial injury are characteristic pathological features of acute respiratory distress syndrome (ARDS)). MicroRNAs involved in the regulation a variety cellular processes including endothelial damage inflammatory responses. However, little is known about their function molecules regulating lung microvascular injury. Here, we determined levels microRNA-92a (miR-92a) lipopolysaccharide (LPS)-induced human pulmonary cells (HPMECs). We found...
Compared with other diseases similar global burdens, little is known about how lifestyle factors than smoking affect respiratory health, and few studies have systematically investigated the combined associations between diet health. The aim of this research was to examine Dietary Inflammation Index (DII), Healthy Eating (HEI)-2015, individual food nutrient multiple outcomes. This study a cross-sectional prospective cohort evaluate data from adults aged 40 years or older (N = 13,227) 4...
Although the drug therapeutic targets of acute respiratory distress syndrome (ARDS) are still unclear and no specific drugs for ARDS treatment have been found, some breakthroughs gradually made in biological target pathways such as endothelial injury. The Traditional Chinese Medicine Systems Pharmacology (TCMSP) database suggests that Acetyl-11-keto-β-boswellic acid (AKBA), a processed product boswellic acid, may be an effective intervention ARDS. After preliminary vitro vivo verification...
There is a lack of large-scale epidemiological data on the clinical practice enteral nutrition (EN) feeding in China. This study aimed to provide such Chinese hospitals and investigate factors associated with EN delivery.This cross-sectional was launched 118 intensive care units (ICUs) 116 mainland conducted April 26, 2017. At 00:00 all patients these ICUs were included. Demographic variables 25 obtained. The dates hospitalization, ICU admission initiation reviewed. outcome status 28 days...
Abstract Background To investigate the difference in severity of illness, organ dysfunction, and prognosis acute cholangitis due to different pathogenic bacterial infection types. Methods A retrospective observational study was performed. Patients who met selection criteria according blood culture bile results were divided into groups. The groups analyzed compared comprehensively. Results total 424 patients included, no growth developed 111 (26.2%). Among 313 (73.8%) with growth, 155 had...
Acute respiratory distress syndrome (ARDS) is a public health problem with high morbidity and mortality worldwide due to lacking known characteristic biomarkers timely intervention. Pulmonary edema caused by inflammation pulmonary microvascular endothelial cell disfunction the main pathophysiological change of ARDS. Circulating microRNAs (miRNAs) are differentially expressed between subjects who did not develop Many miRNAs have been exemplified be involved in ARDS could represent novel...
<b><i>Background:</i></b> Continuous renal replacement therapy (CRRT) and other extracorporeal therapies for acute kidney injury (AKI) organ dysfunction syndromes in critically ill patients are common the intensive care unit (ICU). Many studies have focused on clinical practice managing these conditions. However, there few that describe utilization of therapies, especially CRRT, with sepsis-associated AKI. <b><i>Summary:</i></b> Two hundred ICU...
To evaluate the risk factors and prognosis of patients with acute cholangitis recurrence.A total 503 admitted to First Affiliated Hospital Chongqing Medical University between July 2013 January 2022 were included in this retrospective observational study, who followed up for 360 days divided into relapse group non-recurrence according recurrence cholangitis. Risk analyzed by univariate, multivariate analyses proportional hazards model.A 161 recurrent identified. Recurrent usually occurred...
To identify the risk factors and prognosis of carbapenem-resistant organisms (CRO) in patients with acute cholangitis.This retrospective observational study was conducted to explore CRO infection 503 cholangitis diagnosed between July 2013 January 2022 at First Affiliated Hospital Chongqing Medical University, who were divided into a group non-CRO based on presence or absence CRO. Univariate, multivariate analyses, proportional hazards model used compare suffering cholangitis.We identified...
This study aimed to investigate the role of serum uric acid (UA) in early identification severity, prognosis and complications patients with severe acute pancreatitis (SAP). The clinical data SAP were collected retrospectively (n=268), divided into high UA group low based on median level. Propensity score matching was used make baseline comparable, 85 selected each group. Spearman correlation analysis performed assess relationship between level severity prognosis. ROC curve designed evaluate...
To observe the influence of pre-B-cell colony enhancing factor (PBEF) on intercellular cell adhesion molecule-1 (ICAM-1) and vascular (VCAM-1) in lung tissue rats with acute injury/acute respiratory distress syndrome (ALI/ARDS) induced by oleic acid.A total 40 male adult Sprague-Dawley (SD) were divided into control, model, drug intervention vehicle control groups according to random digits table 10 each group. ALI/ARDS was reproduced injection acid (0.15 ml/kg) through tail vein. The...
Sepsis is a life-threatening organ dysfunction resulting from dysregulated host response to infection. Early recognition and appropriate management improve in-hospital mortality in patients with sepsis. However, many progress chronic critical illness (CCI). Persistent inflammation, immunosuppression, catabolic syndrome (PICS), new phenotype of CCI, characterized by low-grade catabolic-dominant weight loss. Due the complexity pathophysiologic mechanisms PICS, there no effective treatment...