A5005004039- Clinical Nutrition and Gastroenterology
- Sepsis Diagnosis and Treatment
- Nutrition and Health in Aging
- Respiratory Support and Mechanisms
- Pancreatitis Pathology and Treatment
- Immune Response and Inflammation
- Acute Kidney Injury Research
- Inflammation biomarkers and pathways
- Pancreatic and Hepatic Oncology Research
- Abdominal Surgery and Complications
- Anesthesia and Pain Management
- Nausea and vomiting management
- Dental Anxiety and Anesthesia Techniques
- Electrochemical Analysis and Applications
- Calpain Protease Function and Regulation
- Enhanced Recovery After Surgery
- Gallbladder and Bile Duct Disorders
- Metabolomics and Mass Spectrometry Studies
- Advanced Computational Techniques and Applications
- Hemodynamic Monitoring and Therapy
- Advanced biosensing and bioanalysis techniques
- Menopause: Health Impacts and Treatments
- Artificial Intelligence in Healthcare and Education
- Spinal Cord Injury Research
- Tendon Structure and Treatment
Huazhong University of Science and Technology
2021-2024
Shanxi Academy of Medical Sciences
2020-2024
Shanxi Medical University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Peking Union Medical College Hospital
2023-2024
Tongji Hospital
2022-2024
Buchang Pharma (China)
2024
Second Affiliated Hospital of Zhejiang University
2023
Union Hospital
2023
Cixian People's Hospital
2023
In 2012, the European Society of Intensive Care Medicine proposed a definition for acute gastrointestinal injury (AGI) based on current medical evidence and expert opinion. The aim present study was to evaluate feasibility using AGI grading system investigate association between severity grades with clinical outcome in critically ill patients. Adult patients at 14 general intensive care units (ICUs) an expected ICU stay ≥24 h were prospectively studied. grade assessed daily basis (GI)...
Objective This study was designed to observe the effect of toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway activity on sepsis-associated acute kidney injury (SA-AKI), thereby providing new considerations for prevention and treatment SA-AKI.
Abstract Background Previous cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficiently powered study is therefore warranted to ascertain effects guideline implementation on patient-centered outcomes. Methods We conducted a multicenter, cluster-randomized, parallel-controlled trial intensive care units (ICUs) across China. developed...
Sensitive determination of C-reactive protein (CRP) is great significance because it an early indicator inflammation in cardiovascular disease and acute myocardial infarction. A disposable electrode with integrated three-electrode system (working, reference, counter electrodes) has potential the detection biomarkers. In this work, electrochemical immunosensing platform was fabricated on screen-printed carbon (SPCE) by introducing nanochannel arrays gated signals, which can achieve sensitive...
Abstract Background Hospital and ICU structural factors are key affecting the quality of care as well patient outcomes. However, data from China scarce. This study was designed to investigate how differences in outcomes associated with hospital structure variables throughout 2019. Methods a multicenter observational study. Data total 2820 hospitals were collected using National Clinical Improvement System that reports information China. collection consisted a) on factors, including type,...
The role of platelet-derived extracellular vesicles (PEVs) in the development sepsis was investigated this study.After collection blood samples from patients and normal volunteers, (EVs) were separated, followed by isolation PEVs rats. Next, a rat model constructed cecal ligation puncture (CLP), rats received tail vein injection to explore sepsis. Subsequently, nanoparticle tracking analysis (NTA) transmission electron microscopy (TEM) adopted determine diameter EVs observe morphology PEVs,...
The rapid and sensitive detection of the important biomarker C-reactive protein (CRP) is great significance for monitoring inflammation tissue damage. In this work, an electrochemiluminescence (ECL) aptasensor was fabricated based on dual signal amplification CRP in serum samples. sensor constructed by modifying a silica nanochannel array film (SNF) cost-effective indium tin oxide (ITO) electrode using Stöber solution growth method. Gold nanoparticles (AuNPs) were grown situ within...
Abstract Background The 2012 European Society of Intensive Care Medicine (ESICM) guidelines provided a clear definition feeding intolerance (FI). study aimed to investigate the association between FI based on current ESICM and clinical outcome further explore effect duration mortality. Methods Adult patients from 14 general intensive care units (ICUs) with an expected ICU stay ≥24 hours were prospectively studied. Based in first week admission ICU, was categorized as 7‐day persistent...
There is a lack of large-scale epidemiological data on the clinical practice enteral nutrition (EN) feeding in China. This study aimed to provide such Chinese hospitals and investigate factors associated with EN delivery.This cross-sectional was launched 118 intensive care units (ICUs) 116 mainland conducted April 26, 2017. At 00:00 all patients these ICUs were included. Demographic variables 25 obtained. The dates hospitalization, ICU admission initiation reviewed. outcome status 28 days...
Abstract Purpose To investigate the effects of ICU quality control indicators on VAP incidence rate and mortality in China throughout 2019. Methods This was a retrospective study. A total 1267 ICUs from 30 provinces mainland were included. Data collected using National Clinical Improvement System that report information. Ten related analyzed, including 5 structural factors (patient-to-bed ratio, physician-to-bed nurse-to-bed patient-to-physician patient-to-nurse ratio), 3 process (unplanned...
The purpose of the present study is to screen hub genes associated with sepsis, comprehensively understand occurrence and progress mechanism provide new targets for clinical diagnosis treatment sepsis.The microarray data GSE9692 GSE95233 were downloaded from Gene Expression Omnibus (GEO) database. dataset contained 29 children sepsis 16 healthy children, while included 102 septic subjects 22 volunteers. Differentially expressed (DEGs) screened by GEO2R online analysis. DAVID database was...
Many studies have focused on the accuracy rate of intraarticular injection. However, sometimes, even when needle enters joint cavity accurately, it can be difficult to obtain a sufficient amount fluid. This problem may attributable position knee during arthrocentesis. The purpose this prospective study was determine which position, supine or sitting, would yield more fluid arthrocentesis.In study, 40 knees belonging 30 patients with osteoarthritis were examined. randomized between group (20...
Sepsis is a global public health burden. The sequential organ failure assessment (SOFA) the most commonly used scoring system for diagnosing sepsis and assessing severity. Due to widespread use of endotracheal intubation sedative medications in sepsis, accuracy Glasgow Coma Score (GCS) lowest SOFA. We designed this multicenter, cross-sectional study investigate predictive efficiency SOFA with or without GCS on ICU mortality patients sepsis.
Acute traumatic spinal cord injury (tSCI) results in a lifetime of paralysis associated with host medical complications. The developing secondary complications tSCI may result further chronic neurodegenerative diseases. Sevoflurane preconditioning (SF-PreCon) has shown guaranteed protective effects myocardial or cerebral ischemic/reperfusion injury. However, the role SF-PreCon still remains to be elucidated. Here, we found that ameliorated through reducing apoptosis rate and secretion...
In order to explore the effective markers of presepsis in prediction clinical disease and severity, predictive effect lactic acid (Lac) combined with cardiac troponin T (cTnT) 5‐hydroxytryptophan (5‐HT) on severity sepsis intensive care unit (ICU) patients its correlation prognosis is investigated. A total 85 admitted ICU our hospital from January 2020 June 2021 are selected establish group, 72 health examination who received physical during same period included healthy control group. The...
BACKGROUND:We sought to create a model that incorporated ultrasound examinations predict the risk of acute kidney injury (AKI) after percutaneous coronary intervention (PCI) or cardiopulmonary bypass (CPB) surgery. MATERIAL AND METHODS:A total 292 patients with AKI PCI CPB surgery were enrolled for study. Afterwards, treatment-related information, including data pertaining examination, was collected. A random forest and multivariate logistic regression analysis then used establish predictive...
The objective of this study was to explore rehabilitation patients with acute kidney injury (AKI) treated Xuebijing injection by using intelligent medical big data analysis system. Based on Hadoop distributed processing technology, designed a system and tested its performance. Then, used systematically analyze sepsis AKI injection. It is found that the computing time does not increase obviously cases. results systematic showed glomerular filtration rate (59.31 ± 3.87% vs 44.53 3.53%) in...
Foundation models have transformed AI by leveraging large-scale data to efficiently perform diverse tasks, and their applications in bioinformatics are primarily focused on data-centric tasks like cell type annotation gene expression analysis. However, potential extends beyond analysis, offering significant opportunities software development optimization, such as code refinement, tutorial generation, advanced visualization. For example, OpenAI Codex can suggest optimized snippets generate...
Objective: To investigate the feasibility of utilizing current acute gastrointestinal injury(AGI) grading system, and explore association severity AGI grade with clinical outcome in critically ill patients. Methods: The adult patients from 14 general ICUs Zhejiang Province an expected admission to ICU for at least 24 h were recruited, all clinical, laboratory, survival data prospectively collected. was daily assessed based on GIsymptoms, feeding details organ dysfunctionon first week ICU.The...
Objective To investigate the prevalence of feeding intolerance (FI), and to explore FI within 7 days ICU admission in association with clinical outcome critically ill patients. Methods The adult patients from 14 general ICUs Zhejiang Province an expected for at least 24h were recruited March 2014 August 2014, all clinical, laboratory, survival data prospectively collected. The AGI (acute gastrointestinal injury) grade was daily assessed based on (GI) symptoms, details organ...