A5103079841- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Oral Health Pathology and Treatment
- Autoimmune Bullous Skin Diseases
- Nanoplatforms for cancer theranostics
- Platelet Disorders and Treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Metabolism, Diabetes, and Cancer
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- Oral and gingival health research
- Advanced Battery Materials and Technologies
- Photodynamic Therapy Research Studies
- Microtubule and mitosis dynamics
- Advanced Nanomaterials in Catalysis
- Respiratory Support and Mechanisms
- Thermal Expansion and Ionic Conductivity
- Laser Applications in Dentistry and Medicine
- Dyeing and Modifying Textile Fibers
- dental development and anomalies
- Neurofibromatosis and Schwannoma Cases
- Radiomics and Machine Learning in Medical Imaging
- Skin Diseases and Diabetes
- Medical Imaging and Analysis
Sichuan University
2017-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Nanjing Medical University
2024-2025
Lanzhou University
2025
Zhengzhou University
2024-2025
Henan Academy of Sciences
2025
Shandong Agricultural University
2025
Jinan University
2025
Henan Provincial People's Hospital
2024
Harbin Medical University
2021-2023
Purpose: In prostate focal therapy, it is important to accurately localize malignant lesions in order increase biological effect of the tumor region while achieving a reduction dose noncancerous tissue. this work, we proposed transfer learning–based deep learning approach, for classification multiparametric magnetic resonance imaging images. Methods: Magnetic images were preprocessed remove bias artifact and normalize data. Two state-of-the-art convolutional neural network models,...
Proteasome activator 28γ (PA28γ) plays a critical role in malignant progression of various tumors, however, its and regulation are not well understood. Here, using oral squamous cell carcinoma (OSCC) as main research model, we discovered that PA28γ interacted with complement 1q binding protein (C1QBP), which is dependent on the N-terminus C1QBP rather than known functional domain (amino acids 168-213). Notably, found enhances stability OSCC. Functionally, contributes to OSCC by affecting...
FAT1 cadherin exhibits dual tumor suppressor and oncogenic roles across various cancers, but its function in breast cancer remains unclear due to conflicting reports of mutational loss overexpression. In this study, we demonstrate that mRNA protein levels are reduced during mammary transformation, an effect linked promoter methylation rather than events. Subtype-specific analysis reveals high expression correlates with poor outcomes basal-like/triple-negative (TNBC), while elevated luminal...
Abstract Glioblastoma (GBM) is a highly vascular malignant brain tumor that overexpresses endothelial growth factor (VEGF) and phosphofructokinase 1 platelet isoform (PFKP), which catalyzes rate-limiting reaction in glycolysis. However, whether PFKP VEGF are reciprocally regulated during GBM remains unknown. Here, we show can promote EGFR activation-induced expression HIF-1α-dependent -independent manners cells. Importantly, demonstrate EGFR-phosphorylated Y64 has critical roles both...
The driving force of the malignant transformation epithelial cells during oral submucous fibrosis (OSF) is an unsettled debate. We hypothesized that expression and accumulation cancer stem (CSCs) are accompanied by atrophy in OSF.The levels Ki67 (proliferation marker), SOX2, Bmi1 (CSC marker) epithelium early, middle, late stages OSF were measured immunohistochemistry. At same time, we focused on three proteins patients with benign hyperkeratosis dysplasia.The clinical cohort study showed...
Primary cilia, evolutionally conserved organelles involving multiple cell functions, are frequently lost in various cancers. However, little is known about the role of primary cilia oral squamous carcinoma (OSCC).Immunofluorescence staining was applied to detect normal, leukoplakia (OLK) and OSCC tissues. Differentially expressed ciliary genes were screened from TCGA database. Immunohistochemical analysis used for validating correlation between expression interested proteins their regulatory...
In recent years, the application of nanoimaging technology on standardize tumor diagnosis has become a new research hotspot, especially nanoprobes. Our group synthesized kind nanocarrier, mPEG2000-GPLGIAGQ-DSPE, which characteristic matrix metalloproteinase-2 (MMP2) sensitive ability in microenvironment. Meanwhile, encapsulation method is adopted to prepare MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe with mPEG2000-GPLGIAGQ-DSPE as carrier. On one hand, this novel not...
Abstract Objective Proteasome activator 28γ (PA28γ) upregulation plays a critical role in the carcinogenesis of many malignancies, including oral cancer. We aim to screen related genes PA28γ and investigate their function mucosa carcinogenesis. Materials methods Bioinformatics analysis was performed PA28γ. Immunohistochemical carried out validate correlation squamous cell carcinoma (OSCC) detect expression levels whole process The Kaplan–Meier method used for estimating overall survival, Cox...
Burning mouth syndrome is a with tongue as the main affected site and burning pain complaint. Although variety of therapies have been reported to treat BMS, there lack widely recognized it still dilemma for clinicians BMS.To develop position paper provide references clinical practice BMS in China.Under guidance WHO (World Health Organization) Handbook Guideline Development, we used GRADE (Grading Recommendations Assessment, Development Evaluation) approach tool this following steps: setting...
Manganese ion (Mn
Objective: To investigate the feasibility of utilizing current acute gastrointestinal injury(AGI) grading system, and explore association severity AGI grade with clinical outcome in critically ill patients. Methods: The adult patients from 14 general ICUs Zhejiang Province an expected admission to ICU for at least 24 h were recruited, all clinical, laboratory, survival data prospectively collected. was daily assessed based on GIsymptoms, feeding details organ dysfunctionon first week ICU.The...
Current scales for Pemphigus vulgaris (PV) do not adequately represent the clinical variability of oral lesions. This study aimed to develop an independent scale, Oral Lesions Area Index (POLAI), assessment PV exclusively, and compare POLAI, Disease (PDAI), Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) Severity (ODSS) regarding inter- intra-observer reliability validity.
Proteasome activator 28γ (PA28γ) plays a critical role in malignant progression of various tumors, however, its and regulation are not well understood. Here, using oral squamous cell carcinoma (OSCC) as main research model, we discovered that PA28γ interacted with complement 1q binding protein (C1QBP), which is dependent on the N-terminus C1QBP rather than known functional domain (amino acids 168-213). Notably, found can enhance stability OSCC. Functionally, contributes to OSCC by affecting...