A5065991602- Nanoparticle-Based Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Radical Photochemical Reactions
- Sulfur Compounds in Biology
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Receptor Mechanisms and Signaling
- Luminescence and Fluorescent Materials
- Sulfur-Based Synthesis Techniques
- Neurobiology and Insect Physiology Research
- Biomedical Research and Pathophysiology
- Neuroscience of respiration and sleep
- Nanocomposite Films for Food Packaging
- Catalytic C–H Functionalization Methods
- Photoreceptor and optogenetics research
- Financial Markets and Investment Strategies
- Advanced Glycation End Products research
- Curcumin's Biomedical Applications
- Material Properties and Applications
- Proteoglycans and glycosaminoglycans research
- Semiconductor Quantum Structures and Devices
- Studies on Chitinases and Chitosanases
- Adenosine and Purinergic Signaling
- Polysaccharides and Plant Cell Walls
- Chemical Synthesis and Analysis
Center for Excellence in Brain Science and Intelligence Technology
2018-2025
University of Chinese Academy of Sciences
2018-2025
Harbin Medical University
2014-2024
Nanjing Tech University
2023-2024
North China Electric Power University
2022-2023
Nanjing Institute of Technology
2022
Daqing City People's Hospital
2020
Chinese Academy of Sciences
2018-2019
Dominion University College
2009
Old Dominion University
2009
A direct C(sp3)-H sulfinylation reaction of alkanes with sulfinyl sulfones via decatungstate photocatalysis is reported. The generated in situ from sulfinates the presence an acylating reagent were able to trap alkyl radicals that produced photoinduced hydrogen atom transfer alkanes, leading a range sulfoxides. This radical process provides efficient and concise method for synthesis sulfoxides abundant under mild conditions. Using same strategy, aldehydes can also be transferred...
The Suzuki polycondensation of the amphiphilically equipped dibromobenzene derivatives 8 and 11 with benzene diboronic acid ester 12 to new kind polymeric amphiphiles 13 14 is described. They carry at each repeat unit either a hydrophobic alkyl chain hydrophilic dendron oligoethyleneoxy chains (13) or third generation Fréchet-type an (14). Some aspects behavior these four compounds air/water interface on mica are also reported.
Ligands are an important part of targeted drug delivery systems. Optimised lignads not only improve the target efficiency, but also enhance therapeutical effect drugs. In our research, five sugar molecules (Mannose, Galactose, Glucose, Malt disaccharide, and Maltotriose) conjugated PEG600-DSPE were synthesised, which polysaccharides first discovered by us as ligands to modify liposomes, interacts with over expressive GLUT on cancer cells. DiO was encapsulated fluorescent probe evaluate their...
A visible-light initiated deaminative C3 alkylation of quinoxalin-2(1H)-ones with Katritzky salts is reported. This radical process provides an approach to a range alkylated quinoxalin-2(1H)-one derivatives in 40–96% yields under metal- and external photocatalyst-free conditions. The reaction enabled by the deprotonation acidic aminyl intermediates generate corresponding anions, which act as single electron transfer reducing reagents sustain chain. late-stage functionalization drug-based...
Hepatocellular carcinoma (HCC) is a malignant tumor leading cancer-associated high mortality worldwide. Unfortunately, the most commonly used drug therapeutics not only lack of target ability and efficiency, but also exhibit severe systemic toxicity to normal tissues. Thus, effective targeted nanodrug HCC therapy emerging as more important issue. Here, we design develop novel nanomicelles, namely Mannose-polyethylene glycol 600-Nitroimidazole (Man-NIT). This micelle compound with purity...
Herein, we have developed a catalyst-free four-component carbosulfonylation of enamides involving indoles, DABCO·(SO
A novel tumor-targeted glutathione responsive Glycosylated-Camptothecin nanosupramolecular prodrug (CPT-GL NSp) was designed and fabricated via a disulfide bond. The effects of glycoligand with different polarities on solubility, self-assembly, stability, cellular uptake, cleaving were explored, an optimal glycosylated ligand selected for prodrug. It has been found that CPT-GL NSp exhibited higher drug loading than traditional nanoparticles. Among which maltose modified had the strongest...
A novel fluorescent nanoprobe was prepared to measure H 2 S in plasma and tissue samples from ASD patients model mice.
In recent years, the application of nanoimaging technology on standardize tumor diagnosis has become a new research hotspot, especially nanoprobes. Our group synthesized kind nanocarrier, mPEG2000-GPLGIAGQ-DSPE, which characteristic matrix metalloproteinase-2 (MMP2) sensitive ability in microenvironment. Meanwhile, encapsulation method is adopted to prepare MMP2-sensitive tumor-targeted prussian blue fluorescent nanoprobe with mPEG2000-GPLGIAGQ-DSPE as carrier. On one hand, this novel not...
Polyester dendrimers bearing carbazole units at their peripheries were synthesized by attaching 3,5-bis[4-(9-carbazolyl)butoxy]benzoic acid to the peripherical phenoxy groups. The phenoxy-terminated polyester hydrogenation of corresponding benzyloxy-terminated dendrimers. structure compounds was confirmed with IR, 1H NMR, MALDITOF MS and GPC. reaction conditions for groups studied. Fluorescence spectra studies showed that there exist strong intramolecular interactions in dendrimer molecules.
Aryl polyester dendrimers and dendrons have been prepared by using 'branched monomer strategies', in which the surface focal point of multi-branched protected with two different kinds protective group. The group for was stable during deprotection surface. Different wedges could be attached to monomers form large whilst active cores various cores.
Abstract 1,4‐Dibromobenzenes carrying nonpolar hexoxy and polar oligo(ethylene glycol) side chains were subjected to Suzuki polycondensation with a benzene‐1,4‐bisboronic acid ester produce high‐molar‐mass poly( para ‐phenylene)s. The molar masses determined size exclusion chromatography conventional polystyrene universal calibration. These novel amphiphilically equipped rigid‐rod polymers have the potential segregate lengthwise into domains, property that has only rarely been described,...
With aging of population, changing living habits, and intake high-fat diet, more people have been suffering from cardio-cerebral apoplexy. The synchronous treatment conditions based on an integral strategy may bring benefit to the better clinical efficacy. simultaneously-targeting delivery active molecules by nanoscale carriers heart brain remains unmet problem. physiological difference targets between makes it a huge challenge which one targeting ligand modification acquires two organs...
Abstract Norepinephrine (NE) and epinephrine (Epi), two key biogenic monoamine neurotransmitters, are involved in a wide range of physiological processes. However, their precise dynamics regulation remain poorly characterized, part due to limitations available techniques for measuring these molecules vivo . Here, we developed family G PC R A ctivation- B ased NE /Epi (GRAB ) sensors with 230% peak ΔF/F 0 response NE, good photostability, nanomolar-to-micromolar sensitivities, sub-second...
<title>Abstract</title> Autism spectrum disorder (ASD) presents cognitive and social deficits with a lacking brain-targeted medication landscape, notably in nanomedicine. Here, we introduce novel H<sub>2</sub>S donor cross-linked nanomicelles named mannose-PEG600-lipoic acid (Man-LA). Man-LA exhibit enhanced stability precise brain delivery through interaction glucose transporter 1 (GLUT1) astrocytes, facilitating gradual release modulated by glutathione (GSH). <italic>In vivo</italic>,...
Autism spectrum disorder (ASD) is characterized by cognitive inflexibility and social deficits, with a notably limited range of brain-targeted medications, particularly in the field nanomedicine. Herein, we introduce H2S donor cross-linked nanomicelle, named mannose-PEG600-lipoic acid (Man-LA). Man-LA demonstrates enhanced stability precise brain delivery interacting glucose transporter 1 (GLUT1) astrocytes, facilitating gradual release that modulated glutathione (GSH). In vivo, studies...