Current evidence for the combined use of immunotherapy, low-dose chemoradiotherapy, and epidermal growth factor receptor-targeted therapy treatment advanced esophageal squamous cell carcinoma is lacking. We report case a 73-year-old woman with upper middle thoracic esophagus. After undergoing concurrent chemoradiotherapy immunotherapy anti-angiogenic targeted therapy, patient achieved progression-free survival 17 months. To date, has 35 months overall survival, which continues to extend,...

Objective: To compare survival outcomes between cervical adenocarcinoma (ADC) and squamous cell carcinoma (SCC) using a propensity score matching (PSM) analysis based on the Surveillance, Epidemiology, End Results (SEER) Program.Methods: Patients diagnosed with cancer 1998 2016 were identified from SEER database.The Kaplan-Meier method Cox regression used to analyze survival.A subgroup of overall (OS) patients ADC SCC was performed after 1:1 PSM analysis.Results: Of 33,148 patients, 24,591...

To clarify the roles of claudins in endometrial tumorigenesis, we determined levels protein and messengerRNA (mRNA) expression claudin-3 claudin-4 human tissue (proliferative phase [PE, n = 25]; secretory [SE, simple hyperplasia [SH, 20]; complex [CH, 12]; atypical [AH, 15]; endometrioid adenocarcinoma [EEC, 30]) using immunohistochemistry, western blotting, real-time polymerase chain reaction, respectively. Morphologic changes tight junctions (TJs) were also observed normal, hyperplastic,...

There is currently no consensus on the prognostic significance of histological subtype nasopharyngeal carcinoma (NPC). The aim current study was to evaluate impact survival in NPC patients based Surveillance, Epidemiology, and End Results (SEER) Program.Patients with were identified within SEER database (2004-2015). effects cause-specific (CSS) evaluated using univariate multivariate Cox regression analyses. Subgroup analysis according carried out by 1:1 propensity score matching (PSM).A...

Purpose The objective of the study is to systematically identify and evaluate adverse drug reactions (ADRs) associated with combination therapy bevacizumab in patients unresectable hepatocellular carcinoma (HCC). Patients methods Data were extracted from Food Drug Administration (FDA) Adverse Event Reporting System FDA database. Disproportionality analysis was conducted using reporting odds ratio (ROR), proportional (PRR) Bayesian confidence propagation neural network (BCPNN) information...

The precise incidence of immune-related adverse events (irAEs) remains unclear. This pharmacovigilance study investigated acute pancreatitis (AP) associated with immune checkpoint inhibitors (ICIs) using real-world data from the FDA Adverse Event Reporting System (FAERS). Disproportionality analysis employing reporting odds ratios (RORs) was conducted to detect AP signals in ICI-treated patients compared entire FAERS database. A total 152,042 individual were included dataset which we...

BACKGROUND Radiation therapy is an important treatment for esophageal tumors. However, there still controversy regarding the total dose and fraction dose. The optimal fractionation schedule have not yet been clearly established. Hypofractionated radiotherapy becoming more popular, but it unknown whether this choice In addition, appropriate per uncertain. We performed a retrospective study to address these issues. AIM To report cumulative survival toxicity associated with delivered escalation...

There is no clear information regarding the role of FAM181A antisense RNA 1 (FAM181A-AS1) in lung adenocarcinoma (LUAD). We explored relationship between FAM181A-AS1 and LUAD using bioinformatics analysis experimental validation this study. Statistics databases were used to evaluate clinical features patients expression, prognostic factors, regulation network, immune infiltration function. cell lines tested for expression qRT-PCR. showed significantly low patients. Low predicted a poorer...

Objective: Telomere-related genes (TRGs) play a critical role in various types of tumors. However, there is lack comprehensive exploration their relevance lung cancer. This research aimed to verify the relationship between TRGs gene expression and prognosis patients with adenocarcinoma (LUAD), as well prediction drug treatment efficiency. Methods: A total 2093 were acquired from TelNet. The clinical information including age, tumor stage, follow up outcome (death/survival) profile LUAD...

Objective: This study aimed to establish a simplified T classification based on the 8th edition of Union for International Cancer Control/American Joint Committee (UICC/AJCC) staging system nasopharyngeal carcinoma (NPC). Methods: In total, 325 patients with NPC were included in this study. All underwent magnetic resonance imaging, and criteria recorded. These subjected UICC/AJCC NPC. Results: Involvement oropharynx, nasal cavity, adjacent soft tissue (medial pterygoid, lateral prevertebral...

The role of serum CA125 and CEA in the prognosis non-small cell lung cancer (NSCLC) remains controversial, especially early stage patients, which need further clarification.Thus, this study we carried out a large scale retrospective analysis prognostic value 645 patients with NSCLC, to explore their predictive NSCLC.Patients who underwent curative surgical resection for NSCLC were from Zhejiang Cancer Hospital China 2006 2011.Microparticle enzyme immunoassay was used measure preoperative...

Immune checkpoint inhibitors (ICIs) have become an important treatment modality for various malignancies. Due to excessive inflammatory and immune responses, immune-related adverse events (irAEs), such as rash, pruritis, pneumonitis, hepatitis, hypothyroidism, hyperthyroidism fatigue, can occur. Acquired thrombocytopenia is a rare irAE that lead severe low platelet counts hemorrhage. A retrospective observational analysis was conducted on data from the United States Food Drug Administration...

Objective: To investigate the expression of programmed death 1(PD-1) and ligand 1 (PD-L1) on T lymphocyte monocyte from peripheral blood advanced non-small-cell lung cancer (NSCLC) patients its potential role in immune escape NSCLC. Methods: Forty-eight with NSCLC (Lung Cancer Group) were included Department Respiratory Diseases The Second Affiliated Hospital Soochow University June 2014 to 2015. Thirty-six healthy volunteers who received health examination at same time, matching sex, age...

目的 研究氯氧喹联合X射线对Lewis肺癌细胞及荷瘤小鼠的辐射增敏作用.方法 细胞及动物实验均设置为对照组、给药组、照射组及给药+照射组(联合组)4个组别.采用体外细胞培养MTT检测及荷瘤动物模型观察方法,分别予以不同处理因素后,细胞实验用MTT法检测各组别细胞吸光度(A)值;小鼠皮下接种Lewis肺癌细胞,予以相关处理因素后,观察记录肿瘤生长情况并测量其长、宽径从而计算出肿瘤抑制率及肿瘤生长延迟...

Objective To investigate the diagnostic value of bone metabolic markers (BGP, β-CTX and PINP) for metastasis non-small cell lung cancer (NSCLC) analyzed by Logistic regression combined with ROC curve. Methods A total 65 patients stage Ⅳ NSCLC were enrolled in this study. The divided into two groups based on radiological imaging, includirg group (30 cases) non-bone (35 cases). serum concentrations BGP, PINP measured electrochemical method. curve applied to analyze data evaluate...

Objective To explore the efficacy and adverse effects of nimotuzumab combined with chemotherapy radiotherapy in treatment locally advanced cervical cancer. Methods Sixty patients stage Ⅲ cancer by histopathologic diagnosis were collected, they randomly divided into two groups using random number table method. The control group (n=30) intensity-modulated radiotherapy, intracavitary afterloading therapy periodic chemotherapy, observation addition to (200 mg) was given before weekly...

Objective To explore the effect and safety of three-dimensional conformal radiotherapy (3D-CRT) m combination with nimotuzumab chemotherapy in treatment patients locoregionally advanced nasopharyngeal carcinoma.Methods 60 stages Ⅲ-ⅣA carcinoma were enrolled.All treated 3D-CRT concurrent sequential by paclitaxel eisplatin given 100mg i.v.weekly for 6 ～ 7 weeks before radiotherapy.Results After two months,the complete response rates(CR) cervix lymph nodes 98.3％,96.7％ respectively,l-year...

Hypopharyngeal carcinoma is a rare malignancy in China. The incidence about 0.15/100000 male and 0.02/100000 female. However, taking account for the Chinses population base, it not uncommon head neck cancer center.