A5100693497- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Liver Disease and Transplantation
- Dental materials and restorations
- Peptidase Inhibition and Analysis
- Hearing Loss and Rehabilitation
- Hepatitis B Virus Studies
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Wheat and Barley Genetics and Pathology
- Cancer, Hypoxia, and Metabolism
- Dental Implant Techniques and Outcomes
- Hearing, Cochlea, Tinnitus, Genetics
- Plant Pathogens and Fungal Diseases
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- RNA modifications and cancer
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Shandong University
2024-2025
Beijing Agricultural Machinery Research Institute
2025
Gansu Agricultural University
2019-2024
State Key Laboratory of Oncology in South China
2017-2023
Peking Union Medical College Hospital
2023
National Clinical Research
2023
State Key Laboratory of Cardiovascular Disease
2023
In eukaryotes, microtubules are essential for cellular plasticity and dynamics. Here we show that P300/CBP-associated factor (PCAF), a kinetochore-associated acetyltransferase, acts as negative modulator of microtubule stability through acetylation EB1, protein controls the plus ends microtubules. PCAF acetylates EB1 on K220 disrupts hydrophobic cavity dimerized C terminus, which was previously reported to interact with plus-end tracking proteins (TIPs) containing SxIP motif. As determined...
Peritumoral hepatocytes are critical components of the liver cancer microenvironment, However, role peritumoral in local tumor immune interface and underlying molecular mechanisms have not been elucidated. YTHDF2, an RNA N
Abstract Background Patients with hepatocellular carcinoma (HCC) undergoing surgical resection still have a high 5‐year recurrence rate (~ 60%). With the development of laparoscopic hepatectomy (LH), few studies compared efficacy between LH and traditional approach on HCC. The objective this study was to establish nomogram evaluate risk in HCC patients who underwent LH. Methods clinical data 432 patients, pathologically diagnosed HCC, as initial treatment had margin > 1 cm were collected....
Metastasis is a major event for survival and prognosis in patients with head neck squamous cell carcinomas (HNSCC). A primary cause of metastasis the proteolytic degradation extracellular matrix (ECM). The plasminogen activator urokinase (PLAU) involved transformation to plasmin leading hydrolyzation ECM-related proteins. However, role PLAU expression HNSCC unclear worth being investigated.PLAU profiles clinical parameters from multiple datasets were used investigate relationship survival....
Purpose:The prognosis of infiltrative hepatocellular carcinoma (HCC) is dismal.Hepatic arterial infusion chemotherapy (HAIC) plus Lenvatinib (Len) and immune checkpoint inhibitor (ICI) have shown promising results for HCC.However, this three combination therapy on HCC unknown.In study, we compared HAIC lenvatinib programmed cell death protein-1 (PD-1) with Len HCC.Patients Methods: This multi-center cohort study included patients who received combined (HAIC+Len group, n = 173) or PD-1...
Radiofrequency ablation (RFA) is recommended as a first-line therapy for small hepatocellular carcinoma (HCC). Tumor location potential factor influencing the procedure of RFA. To compare oncologic outcomes RFA different tumor locations, this retrospective study enrolled 194 patients with HCC who had undertaken The nodules were classified peri-hepatic-vein (pHV) or non-pHV, peri-portal-vein (pPV) non-pPV, and subcapsular non-subcapsular HCC. regional recurrence-free survival (rRFS), overall...
The current preparation methods of carbon quantum dots (CDs) involve many reaction parameters, which leads to possibilities in the synthesis processes and high uncertainty resultant production performance. Recently, machine learning (ML) have shown great potential correlating selected features applications, can help understand relevant structure-function relationships CDs discover better recipes as well. In this work, we employ ML approach guide blue CD microwave systems. After optimizing...
Purpose:The aim of this study was to investigate the efficacy and safety conversion surgery for advanced hepatocellular carcinoma (HCC) after hepatic arterial infusion chemotherapy (HAIC).Patients Methods: Data from 172 HCC patients treated at Sun Yat-sen University Cancer Center between January 2016 June 2021 with effective assessment HAIC treatment response were retrospectively analyzed.Clinical pathological data, process, survival, occurrence adverse events recorded.Patients grouped...
Abstract Metastasis is one of the primary causes for high mortality in patients with squamous cell carcinoma head and neck (SCCHN). Our previous study showed that chemokine (C‐C motif) ligand 18 (CCL18), derived from tumour‐associated macrophages (TAMs), regulates SCCHN metastasis by promoting epithelial‐mesenchymal transition (EMT) preserving stemness. However, underlying mechanism needs to be further investigation. Interestingly, metadherin (MTDH) expression was induced when cells were...
The prediction model of postoperative survival for single large and huge hepatocellular carcinoma (SLH-HCC, diameter > 5.0 cm) without portal vein tumour thrombus has not been well established. This study aimed to develop novel nomograms predict recurrence these patients.Data from 2469 patients with SLH-HCC who underwent curative resection January 2005 December 2015 in China were retrospectively collected. Specifically, recurrence-free (RFS) overall (OS) using data a training cohort...
Inflammatory response is related to tumor progression and patient survival. We aimed clarify the prognostic value of inflammation-based scores in intrahepatic cholangiocarcinoma (ICC) patients receiving anti-PD1 therapy.A total 73 who received anti-PD-1 therapy from February 2019 2021 were included study. Representative scores, including C-reactive protein (CRP), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte (NLR), lymphocyte-to-CRP (LCR), lymphocyte-to-monocyte (LMR),...
The water invasion within shales easily causes damage to the hydrocarbon flow. However, imbibition mechanisms are still unclear, and mathematical connection between stress-dependent permeability was rarely known. As a result, in this paper, numerical simulation model coupled with imbibition, shale deformation, alteration established analyze how lead an geomechanical properties gas permeability. results showed that proposed validated high pressure experimental data of samples. Moreover, more...
Abstract Background Hearing loss has been associated with serious health problems around the globe. Previous studies have found positive effects of fitting hearing aids on health, but few were conducted in developing countries. The aim this study is to examine multiple outcomes among middle-aged and older adults rural China. Methods In randomized controlled trial (RCT), participants aged 45 above randomly assigned treatment group prescribing or control no intervention. Trial for 385...
Objective: To evaluate whether surgery-related complications are increased after hepatic arterial infusion chemotherapy (HAIC) using oxaliplatin plus fluorouracil/leucovorin for conversion compared with primary hepatocellular carcinoma (HCC) resection and the optimal timing of surgery (CS). Background: HAIC has been widely used advanced HCC, especially initially unresectable to facilitate curative-intent in approximately 23.8% cases. However, reduce surgical must be clarified. Methods: Data...
Background: Systemic chemotherapy (SC) remains the only first-line treatment for unresectable intrahepatic cholangiocarcinoma (iCCA). Hepatic arterial infusion (HAIC) has been recently proven to be effective in managing hepatocellular carcinoma (HCC). Hence, our study aims investigate safety and efficacy of HAIC treating iCCA patients. Methods: We reviewed 146 patients with who had received or SC between March 2016 2022 a retrospective manner. Outcomes were compared groups. Results: There 75...
Background N-lactoylphenylalanine (Lac-Phe) is a new form of “exerkines” closely related to lactate (La), which may be able inhibit appetite. Blood flow restriction (BFR) can lead local tissue hypoxia and increase accumulation. Therefore, this study investigated the effects combining Moderate-intensity Continuous Exercise (MICE) with BFR on Lac-Phe appetite regulation in obese adults. Methods This employed cross-design recruited 14 adults aged 18-24 years. The participants were randomly...
Alpha-fetoprotein (AFP) has been established as a biomarker for hepatocellular carcinoma (HCC); however, whether its dynamic changes could predict the response to systemic therapy remains elusive. This study explored AFP trajectory and association with survival in patients received bevacizumab plus immunotherapy. We retrospectively enrolled 536 HCC immunotherapy between February 2021 2023. Patients were divided into two groups according values before treatment (400 ng/ml). Dynamic of fitted...
Radiation therapy has been refined with increasing evidence of the benefits stereotactic body radiation (SBRT) in treating hepatocellular carcinoma (HCC). In this study, we aimed to evaluate whether SBRT could serve as an alternative radiofrequency ablation (RFA) for small HCC a single lesion ≤5.0 cm.