A5112592834- Coal Properties and Utilization
- Fire dynamics and safety research
- Safety and Risk Management
- Combustion and Detonation Processes
- Fire Detection and Safety Systems
- Geoscience and Mining Technology
- Rock Mechanics and Modeling
- Evacuation and Crowd Dynamics
- Methane Hydrates and Related Phenomena
- Risk and Safety Analysis
- Occupational Health and Safety Research
- Hydrocarbon exploration and reservoir analysis
- Simulation and Modeling Applications
- Coal and Its By-products
- Technology and Security Systems
- Underground infrastructure and sustainability
- Fire effects on ecosystems
- Microtubule and mitosis dynamics
- Wind and Air Flow Studies
- Tunneling and Rock Mechanics
- Geomechanics and Mining Engineering
- Advanced Decision-Making Techniques
- Air Quality Monitoring and Forecasting
- Hydraulic and Pneumatic Systems
- Industrial Technology and Control Systems
China University of Mining and Technology
2013-2024
Shanghai Electric (China)
2024
Xi'an University of Architecture and Technology
2024
China Railway Group (China)
2022
Hefei National Center for Physical Sciences at Nanoscale
2012-2014
University of Science and Technology of China
2011-2014
Shenzhen University
2012
UPMC Hillman Cancer Center
2011
Beijing University of Chinese Medicine
2011
Morehouse School of Medicine
2011
In eukaryotes, microtubules are essential for cellular plasticity and dynamics. Here we show that P300/CBP-associated factor (PCAF), a kinetochore-associated acetyltransferase, acts as negative modulator of microtubule stability through acetylation EB1, protein controls the plus ends microtubules. PCAF acetylates EB1 on K220 disrupts hydrophobic cavity dimerized C terminus, which was previously reported to interact with plus-end tracking proteins (TIPs) containing SxIP motif. As determined...
Abstract During progression of hepatocellular carcinoma, multiple genetic and epigenetic alterations act to posttranslationally modulate the function proteins that promote cancer invasion metastasis. To define such abnormalities contribute liver metastasis, we carried out a proteomic comparison primary carcinoma samples intravascular thrombi from same patient. Mass spectrometric analyses revealed series acidic phospho-isotypes associated with samples. In particular, found Thr567...
Entosis, a cell-in-cell process, has been implicated in the formation of aneuploidy associated with an aberrant cell division control. Microtubule plus-end-tracking protein TIP150 facilitates loading MCAK onto microtubule plus ends and orchestrates plus-end dynamics during division. Here we show that cooperates to govern entosis via regulatory circuitry involves Aurora A-mediated phosphorylation MCAK. Our biochemical analyses forms intra-molecular association, which is essential for binding....
Visualization of specific molecules and their interactions in real time space is essential to delineate how cellular dynamics the signaling circuit are orchestrated. Spatial regulation conformational structural plasticity protein required rewire circuitry response extracellular cues. We introduce a method for optically imaging intracellular at nanometer spatial resolution live cells, using photoactivatable complementary fluorescent (PACF) proteins. Subsets were activated, localized, then...
Following a fire incident in coal mine dead-end roadway, shutting down the local ventilator can influence progression. This study delves into impact of shutdown time (i.e. air supply cessation time) on source combustion dynamics through small-scale experiments. Results indicate that sudden will prompt ghosting flame and even self-extinguishing. The emerges due to uneven distribution fuel vapor oxygen concentrations, its moving direction is related ventilation conditions mode. And burning...
In the event of a mine fire, rapidly constructing blast-resistant seals is one most effective measures to contain disaster. This study conducted blast cushioning experiments on sealed airbags and numerical simulations by analysis system/Livermore software-dynamics (ANSYS/LS-DYNA), an explicit simulation software, analyze mechanical response characteristics effectiveness under different length-to-diameter ratios. The research results indicate that with ratios all exhibit effects, airbag can...
Accurate and rapid measurement of ventilation resistance is crucial for achieving effective real-time airflow control in underground systems. Conventional methodologies are frequently constrained by operational inefficiency substantial inaccuracies. To overcome these limitations, this study proposes an innovative approach employing fractal theory to quantify roadway surface roughness determine parameters. The characterization utilizes two descriptors: dimension (D) scale parameter (C)....
The phase change and diffusion behavior of liquid nitrogen in loose media is a key scientific issue for improving the efficiency mine fire prevention extinguishing technologies. This study systematically investigates coupling mechanism seepage during transient flow using self-developed experimental platform. results indicate that injection, vapor lock phenomenon, significantly influenced by combined effect vaporization expansion force gravity, inhibits leads to non-uniform temperature...
In order to reveal the law of air leakage and gas distribution in goaf fully mechanized mining face under Y-type ventilation, numerical simulation was carried out with Comsol Multiphysics multi-physical field software background 31009 working Yangquan Xinyuan Coal Mine. Through results, we can see that Y ventilation mode affects depth 2–3 m more than U mode, uses airflow auxiliary inlet disperse accumulation upper corner. The results show from is 481.92 m3/min; high area 46.5 front face,...
In this study, smoke movement characteristics and temperature in the blind roadway connected main were mainly investigated numerically. The outcomings indicate that as fire source gradually moves away from heading face, flame tilts face to portal of roadway. gas downstream during ventilation is higher than situation without ventilation, it depends only on location. high-temperature will generate energy loss passed through bifurcation structure, resulting a sudden decline longitudinal...
We identified the main heat source of refuge chamber was hedge staff by analyzing chamber. calculation method released and calcium hydroxide when absorbed CO2. designed experimental program temperature control phase change material according to estimate dissipating capacity in 96 hours. Ultimately, we conducted simulation experiments verified effect material.