A5033061995- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Nerve injury and regeneration
- Cancer, Lipids, and Metabolism
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholesterol and Lipid Metabolism
- Plant Stress Responses and Tolerance
- Uterine Myomas and Treatments
- Inflammatory mediators and NSAID effects
- Parkinson's Disease Mechanisms and Treatments
- Endometriosis Research and Treatment
- Sirtuins and Resveratrol in Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- COVID-19 Clinical Research Studies
- Autophagy in Disease and Therapy
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Ion channel regulation and function
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Disease and Adiposity
- Gynecological conditions and treatments
Shanghai University of Traditional Chinese Medicine
2016-2025
Jiangxi Provincial Cancer Hospital
2016-2020
Shanghai Jiao Tong University
2009-2018
Northwest A&F University
2017-2018
YangPu Geriatric Hospital
2018
Ruijin Hospital
2018
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2016-2017
Nanchang University
2016
Yangpu Hospital of Tongji University
2011-2013
Since melatonin was identified in plants decades ago, much attention has been devoted to discovering its role plant science. There is still a great deal learn about the functional importance of melatonin, as well mode. In this paper, we examine treatment response Malus hupehensis Rehd. alkaline conditions. Stressed seedlings showed chlorosis and suppressed growth. However, phenotype ameliorated when 5 µM added irrigation solution. This supplementation also associated with reduction cell...
The aim of this study was to investigate the mechanisms through which quercetin protects against atherosclerosis (AS) in apoE‑/‑ mice by regulating expression proprotein convertase subtilisin/kexin type 9 (PCSK9), cluster differentiation 36 (CD36), peroxisome proliferator‑activated receptor γ (PPARγ), liver X α (LXRα) and ATP binding cassette transporter A1 (ABCA1). We established an animal model high‑fat diet induced AS using mice. H&E, Oil Red O Masson's trichrome staining were performed...
Abstract Objective To examine the role of high‐fat and high‐sugar (HFHS) diet‐induced oxidative stress, which is a risk factor for various diseases, in premature ovarian failure (POF). Materials methods Ovarian granulosa cells (OGCs) were isolated from mice cultured medium supplemented with HFHS poly (lactic‐co‐glycolic acid) (PLGA)‐cross‐linked miR‐146b‐5p nanoparticles (miR‐146@PLGA). RNA protein expression levels examined using quantitative real‐time polymerase chain reaction Western...
The intermediate-conductance Ca2+-activated K+ channel KCa3.1 was recently shown to control the phenotype switch of reactive astrogliosis (RA) in Alzheimer's disease (AD).KCa3.1 channels expression and cell localization brains AD patients APP/PS1 mice model were measured by immunoblotting immunostaining. KCa3.1-/-/APP/PS1 subjected Morris water maze test evaluate spatial memory deficits. Glia activation neuron loss Fluo-4AM used measure cytosolic Ca2+ level β-amyloid (Aβ) induced astrocytes...
Accumulating evidence indicates that microglia activation is associated with an increased risk for developing Parkinson's disease (PD). With the progressive and selective degeneration of dopaminergic (DA) neurons, proinflammatory cytokines are elevated in substantia nigra (SN) PD patients. Thus, anti-inflammation has become one therapeutic strategies PD. Eriocalyxin B (EriB), a diterpenoid isolated from Isodoneriocalyx, was previously reported to have anti-inflammatory effects. MPTP mouse...
Aging is the major risk factor for diseases of cardiovascular system, such as coronary atherosclerotic heart disease, but little known about relationship between atherosclerosis (AS) and age‑related declines in vascular structure function. Here, we used histological analyses combination with molecular biology techniques to show that lipid deposition endothelial cell was accompanied by aging growth arrest. Endothelial senescence sufficient cause AS; however, found salidroside reduced...
Recent studies described a critical role for microglia in Parkinson's disease (PD), where these central nerve system resident immune cells participate the neuroinflammatory microenvironment that contributes to dopaminergic neurons loss substantia nigra. Understanding phenotype switch of microgliosis PD could help identify molecular mechanism which attenuate or delay progressive decline motor function. KCa3.1 has been reported regulate "pro-inflammatory" neurodegenerative pathological...
Atherosclerosis (AS) is a complex vascular disease that seriously harms the health of elderly. It closely related to endothelial cell aging, but role senescent cells in atherogenesis remains unclear. Studies have shown peroxisome proliferator‐activated receptor alpha (PPAR α ) inhibits development AS by regulating lipid metabolism. Our previous research showed PPAR was involved repair damaged cells. Using molecular biology and approaches detect atherosclerosis‐prone apolipoprotein...
Abstract Background Vascular aging is an important pathophysiological basis for the senescence of various organs and systems in human body, it a common pathogenetic trigger many chronic diseases elderly. Methods The extracellular vesicles (EVs) from young aged umbilical vein endothelial cells were isolated identified by qPCR differential expression levels 47 mRNAs genes closely related to two groups. Results There significant differences 18 (we noted upregulation PLA2G12A, TP53BP1, CD144,...
An inflammatory cytokine storm is considered an important cause of death in severely and critically ill COVID-19 patients, however, the relationship between SARS-CoV-2 spike (S) protein host's not clear.Here, qPCR results indicated that S induced a significantly elevated expression multiple factor mRNAs peripheral blood mononuclear cells (PBMCs), whereas RS-5645 ((4-(thiophen-3-yl)-1-(p-tolyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone) attenuated most mRNAs.RS-5645 also reduced...
Traumatic spinal cord injury (SCI) leads to permanent neurological deficits, which, in part, is due the inability of mature axons regenerate mammalian central nervous system (CNS). The oligodendrocyte myelin glycoprotein (OMgp) one myelin-associated inhibitors neurite outgrowth CNS. To date, limited information available concerning its expression following SCI, possibly lack a reliable antibody against it. Here we report generation highly specific OMgp polyclonal from rabbit. Using this...
Abstract Autophagy is a conserved catabolic process, which functions in maintenance of cellular homeostasis eukaryotic cells. The self-eating process engulfs long-lived proteins and organelles with double-membrane vesicles, forms so-called autophagosome. Degradation contents via fusion lysosome provides recycled building blocks for synthesis new molecules during stress, e.g. starvation. Peiminine steroidal alkaloid extracted from Fritillaria thunbergii widely used Traditional Chinese...
Aging of vascular smooth muscle cells (VSMCs) is the principal factor responsible for loss function, and continuous exposure to high glucose one key factors contributing aging VSMCs. This study established a glucose-induced senescence model A7r5 cell line used transcriptome sequencing screen regulatory target genes cellular senescence. The revealed that expression Slc25a12 gene, which belongs solute carrier family 25 member 12, was notably reduced following damage caused by levels....
Endothelial dysfunction caused by endothelial cell injuries is the initiating factor for atherosclerosis (AS), and lipid peroxidative injury one of a dominant AS pathogenesis. Using RNA-seq, we compared changes in transcriptome expression before after injury, found 311 differentially expressed genes (DEGs), which 258 were upregulated 53 downregulated. The protein–protein interactions (PPIs) between analysed using STRING database, PPI network DEGs was constructed. relationship distributions...
Background: Atherosclerosis is a chronic disease characterized by lipid accumulation, apoptosis and necrosis, smooth muscle cell proliferation local inflammation. Polygonum multiflorum & Codonopsis pilosula Granule (PmCp Granule), akidney-tonifying compound used in Chinese medicine, has been for the clinical treatment of atherosclerosis past 10 years exhibits good therapeutic effects.Aims Objectives: We want to prove that PmCp inhibits expression DAB2IP-ASK1 pathway vascular endothelial...
Background: Quercetin and its derivatives are the most widely distributed flavonoids, which have many pharmacological activities, such as anti-oxidation, anti-aging anti-inflammatory, inhibits occurrence of atherosclerosis (AS) due to antioxidant activity, but mechanism is unknown.