A5016337270- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Asthma and respiratory diseases
- Nerve injury and regeneration
- Medicinal Plants and Neuroprotection
- Autophagy in Disease and Therapy
- Functional Brain Connectivity Studies
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Spinal Cord Injury Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Parkinson's Disease Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Dementia and Cognitive Impairment Research
- Ion Channels and Receptors
- Neurogenesis and neuroplasticity mechanisms
- Invertebrate Immune Response Mechanisms
- Advanced Glycation End Products research
- Occupational exposure and asthma
- Sleep and Wakefulness Research
Shanghai Jiao Tong University
2015-2025
China Medical University
2022-2024
Fourth Affiliated Hospital of China Medical University
2024
Minzu University of China
2024
Shanghai University of Traditional Chinese Medicine
2013-2022
State Key Laboratory of Oncogene and Related Genes
2022
Chiba University
2020
YangPu Geriatric Hospital
2015-2019
Nanchang University
2019
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2015-2016
Abstract Microglia are progressively activated by inflammation and exhibit phagocytic dysfunction in the pathogenesis of neurodegenerative diseases. Lipid-droplet-accumulating microglia were identified aging mouse human brain; however, little is known about formation role lipid droplets microglial neuroinflammation Alzheimer’s disease (AD). Here, we report a striking buildup accumulation 3xTg brain. Moreover, observed significant upregulation PKM2 sterol regulatory element binding protein 1...
Autophagy is a major regulator of the ageing process central nervous system and neurodegeneration. dysfunction has been implicated in pathogenesis Alzheimer's disease (AD). TRPV1 was reported to regulate autophagy protect against foam cell formation reduce release inflammatory factors atherosclerosis. In this study, pharmacological activation with agonist capsaicin induced TRPV1-dependent manner both primary microglia BV2 cells. TRPV1-mediated regulated glycolysis oxidative phosphorylation...
Abstract Background The α-synuclein released by neurons activates microglia, which then engulfs for degradation via autophagy. Reactive microglia are a major pathological feature of Parkinson’s disease (PD), although the exact role in pathogenesis PD remains unclear. Transient receptor potential vanilloid type 1 (TRPV1) channels nonselective cation channel protein that have been proposed as neuroprotective targets neurodegenerative diseases. Methods Using metabolic profiling, energy...
Abstract Although the ε4 allele of apolipoprotein E (ApoE4) gene has been established as a genetic risk factor for many neurodegenerative diseases, including Alzheimer’s disease, mechanism action remains poorly understood. Transient receptor potential vanilloid 1 (TRPV1) was reported to regulate autophagy protect against foam cell formation in atherosclerosis. Here, we show that ApoE4 leads lipid metabolism dysregulation microglia, resulting enhanced MHC-II-dependent antigen presentation and...
Abstract The microenvironment mediated by the microglia (MG) M1/M2 phenotypic switch plays a decisive role in neuronal fate and cognitive function of Alzheimer's disease (AD). However, impact metabolic reprogramming on microglial polarization its underlying mechanism remains elusive. This study reveals that cordycepin improved memory APP/PS1 mice, as well attenuated damage triggering MG‐M2 characterized increased OXPHOS glycolysis, rather than directly protecting neurons. Simultaneously,...
As a systemic syndrome characterized by age-associated degenerative skeletal muscle atrophy, sarcopenia leads to risk of adverse outcomes in the elderly. Age-related iron accumulation is found muscles animal models and patients, but role remains poorly understood. It has been recently that overload several diseases involved ferroptosis, an iron- dependent form programmed cell death. However, whether this excess can result ferroptosis still unclear. In our present study, we ferric citrate...
Abstract Background Ribosomal protein S6 kinase 1 (S6K1) is a serine–threonine that has two main isoforms: p70S6K (70-kDa isoform) and p85S6K (85-kDa isoform). p70S6K, with its upstream mammalian target of rapamycin (mTOR), been shown to be involved in learning memory participate the pathophysiology Alzheimer’s disease (AD). However, function long neglected due high similarity p70S6k. The role still largely unknown. Methods We fractionated postsynaptic densities illustrate differential...
Abstract Background Persistent innate and adaptive immune responses in the brain contribute to progression of Alzheimer’s disease (AD). APOE4 , most important genetic risk factor for sporadic AD, encodes apolipoprotein E4, which by itself is a potent modulator response. However, little known about hub that governs crosstalk between nervous systems. Transient receptor potential vanilloid type 1 (TRPV1) channel ligand-gated, nonselective cation with Ca 2+ permeability, has been proposed as...
Reactive astrogliosis, characterized by cellular hypertrophy and various alterations in gene expression proliferative phenotypes, is considered to contribute brain injuries diseases as diverse trauma, neurodegeneration, ischemia. KCa3.1 (intermediate-conductance calcium-activated potassium channel), a channel protein, has been reported be up-regulated reactive astrocytes after spinal cord injury vivo. However, little known regarding the exact role of astrogliosis. To elucidate regulating we...
Objective: Accurate diagnosis of early Alzheimer disease (AD) plays a critical role in preventing the progression memory impairment. We aimed to develop new deep belief network (DBN) framework using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) metabolic imaging identify patients at mild cognitive impairment (MCI) stage with presymptomatic AD and discriminate them from other MCI. Methods: 18F-fluorodeoxyglucose-PET images 109 recruited ongoing longitudinal Alzheimer’s...
Background Acupuncture is a potential therapy for Alzheimer's disease (AD), but its clinical effects and underlying mechanisms are not fully understood. Emerging evidence suggests autophagy involved in β-amyloid (Aβ) clearance. We hypothesised that electroacupuncture (EA) treatment of AD involves the pathway rats. Methods injected 2μl Aβ 1–40 bilaterally into hippocampi 42 rats to establish AD. Rats remained untreated (AD group, n=14) or received 24 EA treatments at GV20+BL23 over 28 days...
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Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta, tau, and α-synuclein aggregates neurodegenerative diseases. However, due to the complex structure ambiguous pathogenic species of proteins, a universal approach remove remains unavailable. Here, we found that polyphenol, α-mangostin, reprogrammed metabolism disease-associated microglia through shifting glycolysis oxidative phosphorylation, which holistically rejuvenated microglial capacity...
The intermediate-conductance Ca2+-activated K+ channel KCa3.1 was recently shown to control the phenotype switch of reactive astrogliosis (RA) in Alzheimer's disease (AD).KCa3.1 channels expression and cell localization brains AD patients APP/PS1 mice model were measured by immunoblotting immunostaining. KCa3.1-/-/APP/PS1 subjected Morris water maze test evaluate spatial memory deficits. Glia activation neuron loss Fluo-4AM used measure cytosolic Ca2+ level β-amyloid (Aβ) induced astrocytes...
Neuroinflammation may induce a phenotype switch to reactive astrogliosis in neurodegenerative disorders. The calcium-activated potassium channel (KCa3.1) is active the phenotypic that occurs during Alzheimer's disease and ischemic stroke. Here, transcriptome sequencing (RNA-Seq), immunohistochemistry, western blotting, pharmacological blockade, calcium imaging were used investigate astrocyte KCa3.1 activity neuroinflammation, Tau accumulation, insulin signaling deficits male wild-type...
Abstract Background Epithelial-mesenchymal transition (EMT) has been proposed as a mechanism in the progression of airway diseases and cancer. Here, we explored role acetylcholine (ACh) pathway involved process EMT, well effects mAChRs antagonist. Methods Human lung epithelial cells were stimulated with carbachol, an analogue ACh, mesenchymal marker proteins evaluated using western blot immunofluorescence analyses. Results Decreased E-cadherin expression increased vimentin α-SMA induced by...
Recent studies described a critical role for microglia in Parkinson's disease (PD), where these central nerve system resident immune cells participate the neuroinflammatory microenvironment that contributes to dopaminergic neurons loss substantia nigra. Understanding phenotype switch of microgliosis PD could help identify molecular mechanism which attenuate or delay progressive decline motor function. KCa3.1 has been reported regulate "pro-inflammatory" neurodegenerative pathological...
Mapping the human brain is one of great scientific challenges 21st century. Brain network analysis an effective technique based on graph theory that widely used to investigate patterns in brain. Currently, mapping individual using a single image has been hotspot field science; techniques, such as Kullback-Leibler (KL) method, have applications structural Magnetic Resonance (MR) imaging. However, maintaining image's intensity, shape, texture and gradient information during feature extraction...