miR-122 is a highly abundant, hepatocyte-specific microRNA. The biomedical significance and regulatory mechanisms of remain obscure. We explored the role in tumorigenesis context gene network. promoter its transactivator were identified by way luciferase reporter system, electrophoretic mobility shift, chromatin immunoprecipitation assays. circuitry implication hepatocarcinogenesis using livers different development stages, human hepatocellular carcinoma (HCC) tissues cell lines, aflatoxin...

Alzheimer's disease (AD) is the most common age-related form of dementia, associated with deposition intracellular neuronal tangles consisting primarily hyperphosphorylated microtubule-associated protein tau (p-tau) and extracellular plaques comprising amyloid- β (Aβ) peptide. The p-tau tangle unit a posttranslational modification normal protein. Aβ neurotoxic peptide excised from amyloid-β precursor (APP) by β-site APP-cleaving enzyme 1 (BACE1) γ-secretase complex. MicroRNAs (miRNAs) are...

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with loss of cognitive, executive, and other mental functions, the most common form age-related dementia. Amyloid-β peptide (Aβ) contributes to etiology progression disease. Aβ derived from amyloid-β precursor protein (APP). Multiple microRNA (miRNA) species are also implicated in AD. We report that human hsa-miR20b-5p (miR-20b), produced MIR20B gene on Chromosome X, may play complex roles AD pathogenesis,...

Abstract Background The α-synuclein released by neurons activates microglia, which then engulfs for degradation via autophagy. Reactive microglia are a major pathological feature of Parkinson’s disease (PD), although the exact role in pathogenesis PD remains unclear. Transient receptor potential vanilloid type 1 (TRPV1) channels nonselective cation channel protein that have been proposed as neuroprotective targets neurodegenerative diseases. Methods Using metabolic profiling, energy...

This review summarizes the properties of stretchable hydrogels and their optimization for TENGs in on-skin electronics, highlighting applications addressing challenges related to durability user comfort.

// Chunxian Zeng 1,* , Yun-Long Wang Chen Xie 2 Ye Sang 1 Tuan-Jie Li Min Zhang Ruizhi Qi Limin Zheng Shi-Mei Zhuang 1,2 Key Laboratory of Gene Engineering The Ministry Education, State Biocontrol, Collaborative Innovation Center for Cancer Medicine, School Life Sciences, Sun Yat-sen University, Guangzhou, P.R. China Liver Disease Guangdong Province, Third Affiliated Hospital, * These authors have contributed equally to this work Correspondence to: Zhuang, email: Keywords : hepatic fibrosis,...

Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although considered a sparsely...

Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although considered a sparsely...

The reciprocal relationship between sleep and epilepsy has been reported by numerous clinical studies. However, the underlying neural mechanisms are poorly understood. Animal models of powerful tools to tackle this question. A lagging research area is understudied in models. Here, we characterize architecture its with seizures a mouse model sleep-related hypermotor epilepsy, caused mutation KCNT1. We demonstrated that nocturnal tonic-clonic induce more non-rapid eye movement (NREM) but...

Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma, sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles in mice. We found that major glutamatergic cell populations DG infraslow (0.01–0.03 Hz) NREM sleep. Although considered a sparsely...

Abstract Alzheimer’s disease (AD) is marked by neurofibrillary tangles and senile plaques composed of amyloid β (Aβ) peptides. However, specific contributions different cell types to Aβ deposition remain unknown. Non-coding microRNAs (miRNA) play important roles in AD regulating translation major associated proteins, such as precursor protein (APP) β-site APP-cleaving enzyme (BACE1), two key proteins with biogenesis. MiRNAs typically silence expression via binding sites mRNAs’...

Alzheimers disease (AD) is a progressive degenerative characterized by significant loss of neurons and synapses in cognitive brain regions the leading cause dementia worldwide. AD pathology comprises extracellular amyloid plaques intracellular neurofibrillary tangles. However, triggers this are still poorly understood. Repressor element 1-silencing transcription/neuron-restrictive silencer factor (REST/NRSF), transcription repressor neuronal genes, dysregulated during pathogenesis. How REST...

This article aims to explore the characteristics of computed tomography (CT) images ovarian vein syndrome (OVS). The approval research ethics committee and written informed consent patients were obtained. CT 11 who had been diagnosed with OVS retrospectively analyzed. All examined urogram, both plain scans enhanced (including arterial phase, venous secretory phase). datum was pulled into a computer workstation for post-processing. Ureteral obstruction at position ureteral dilation above it,...

Protein self-assembly and formation of amyloid fibers is an early event numerous human diseases. Continuous aggregation in vitro produces biogels, which led us to suspect that plaques neurofibrillary tangles Alzheimer’s disease are biogels nature. We applied atomic force microscopy, size exclusion chromatography, differential scanning calorimetry elucidate the gel’s structure, kinetics gel formation, melting point. found (1) lysozyme gelation occurs when protein concentration above 5 mg/mL;...

Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although considered a sparsely...

Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) electrophysiological optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although...