A5100450248- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- Metal complexes synthesis and properties
- Photodynamic Therapy Research Studies
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Neurogenesis and neuroplasticity mechanisms
- Cerebrospinal fluid and hydrocephalus
Fudan University
2016-2025
Pudong Medical Center
2019-2025
Second Affiliated Hospital of Nanjing Medical University
2024
Nanjing Medical University
2023
Nanjing Drum Tower Hospital
2022-2023
Zhejiang Chinese Medical University
2023
Zhejiang University
2023
Hangzhou First People's Hospital
2023
China Medical University
2022
Beijing University of Chinese Medicine
2022
The dissemination, seeding, and colonization of circulating tumor cells (CTCs) serve as the root distant metastasis. As a key step in early stage metastasis formation, CTCs (pre-)metastatic niche appears to be valuable target. Evidence showed that inflammatory neutrophils possess both CTC- niche-targeting property by intrinsic cell adhesion molecules on neutrophils. Inspired this mechanism, we developed nanosize neutrophil-mimicking drug delivery system (NM-NP) coating membranes surface...
Amyloid-beta (Aβ) accumulation in the brain is believed to play a central role Alzheimer's disease (AD) pathogenesis, and common late-onset form of AD characterized by an overall impairment Aβ clearance. Therefore, development nanomedicine that can facilitate clearance represents promising strategy for intervention. However, previous work this kind was concentrated at molecular level, disease-modifying effectiveness such has not been investigated clinically relevant biological systems. Here,...
Abstract Hyperactivated Ras regulates many oncogenic pathways in several malignant human cancers including glioblastoma and it is an attractive target for cancer therapies. activation cells drives protein internalization via macropinocytosis as a key nutrient-gaining process. By utilizing this unique endocytosis pathway, here we create biologically inspired nanostructure that can induce to ‘drink drugs’ targeting activating transcription factor-5 (ATF5), overexpressed anti-apoptotic factor...
Abstract The dismal prognosis for glioblastoma multiform (GBM) patients is primarily attributed to the highly invasive tumor residual that remained after surgical intervention. development of precise intraoperative imaging and postoperative removal techniques will facilitate gross total elimination GBM. Here, a self‐disassembling porphyrin lipoprotein‐coated calcium peroxide nanoparticles (PLCNP) developed target GBM via macropinocytosis, allowing fluorescence‐guided surgery improving...
The upsurge of novel nanomaterials and nanotechnologies has inspired the researchers who are striving for designing safer more efficient drug delivery systems cancer therapy. Stimuli responsive nanomaterial offered an alternative to design controllable system on account its spatiotemporally properties. Additionally, external stimuli (light, magnetic field ultrasound) could develop into theranostic applications personalized medicine use because their unique characteristics. In this review, we...
Alzheimer's disease (AD) exerts a heavy health burden for modern society and has complicated pathological background. The accumulation of extracellular β-amyloid (Aβ) is crucial in AD pathogenesis, Aβ-initiated secondary processes could independently lead to neuronal degeneration pathogenesis AD. Thus, the development combination therapeutics that can not only accelerate Aβ clearance but also simultaneously protect neurons or inhibit other subsequent cascade represents promising strategy...
Abstract Pancreatic cancer is a highly aggressive malignancy that strongly resists extant treatments. The failure of existing therapies majorly attributed to the tough tumor microenvironment (TME) limiting drug access and undruggable targets cells. formation suppressive TME regulated by transforming growth factor beta (TGF‐β) signaling, while poor response short survival almost 90% pancreatic patients results from oncogenic KRAS mutation. Hence, simultaneously targeting both TGF‐β pathways...
Abstract The limited benefits of immunotherapy against glioblastoma (GBM) is closely related to the paucity T cells in brain tumor bed. Both systemic and local immunosuppression contribute deficiency tumor-infiltrating cells. However, current studies focus heavily on immunosuppressive microenvironment but not co-existence immunosuppression. Here, we develop a nanostructure named Nano-reshaper co-encapsulate lymphopenia alleviating agent cannabidiol lymphocyte recruiting cytokine LIGHT....
Abstract Mitochondrial dysfunction has been recognized as the key pathogenesis of most neurodegenerative diseases including Alzheimer's disease (AD). The dysregulation mitochondrial calcium ion (Ca 2+ ) homeostasis and permeability transition pore (mPTP), is a critical upstream signaling pathway that contributes to cascade in AD pathogenesis. Herein, “two‐hit braking” therapeutic strategy synergistically halt Ca overload mPTP opening put on brake proposed. To achieve this goal, magnesium (Mg...
Apoptotic vesicles (ApoVs) hold great promise for inflammatory regulation and tissue repair. However, little effort has been dedicated to developing ApoV-based drug delivery platforms, while the insufficient targeting capability of ApoVs also limits their clinical applications. This work presents a platform architecture that integrates apoptosis induction, loading, functionalized proteome regulation, followed by modification, enabling creation an apoptotic vesicle system treat ischemic...
Tumor cell-derived cancer nanovaccines introduce tumor components as functional units that endow the nanovaccine systems with some advantages, especially providing all potential antigens. However, cumbersome assembly steps, risks of exogenous adjuvants, well insufficient lymph node (LN) targeting and dendritic cell (DC) internalization limit efficacy clinical translation existing nanovaccines. Herein, we introduced an endoplasmic reticulum (ER) stress inducer α-mangostin (αM) into cells...
Chemotherapy failure of glioma, the most aggressive and devastating cancer, might be ascribed to physiologic barriers tumor mainly including heterogeneous perfusion vascular permeability, which result in a limited penetration chemotherapeutics. Besides, vasculogenic mimicry (VM) channels, are highly resistant anti-angiogenic therapy serve as complement angiogenesis, were abound glioma always associated with recurrence. In order enhance effect anti-glioma, we developed PEG–PLA-based nanodrug...
Pancreatic ductal adenocarcinoma (PDAC) strongly resists standard therapies since KRAS-mutated cancer cells harbor endogenous resistance toward chemotherapy-induced apoptosis and tumor-associated macrophages (TAMs) activate stroma to create the nearly impenetrable matrix. Herein, we developed a tailored nanocomplex through self-assembly of synthetic 4-(phosphonooxy)phenyl-2,4-dinitrobenzenesulfonate Fe3+ followed by hyaluronic acid decoration, realizing chemodynamic therapy (CDT) combat...
Metastasis is the major cause of high mortality in cancer patients; thus, blocking metastatic process critical importance for treatments. The premetastatic niche, a specialized microenvironment with aberrant changes related to inflammation, allows colonization circulating tumor cells (CTCs) and serves as potential target metastasis prevention. However, little effort has been dedicated developing nanomedicine amend niche. Here this study reports niche-targeting micelle modulation...
Abstract Failure of conventional clinical therapies such as tumor resection and chemotherapy are mainly due to the ineffective control metastasis. Metastasis consists three steps: (i) cells extravasate from primary sites into circulation system via epithelial-mesenchymal transition (EMT), (ii) circulating (CTCs) form “micro-thrombi” with platelets evade immune surveillance in circulation, (iii) CTCs colonize pre-metastatic niche. Here, we design a systemic metastasis-targeted nanotherapeutic...
High level of detrimental factors including reactive oxygen species (ROS) and inflammatory cytokines accumulated in the infarct core their erosion to salvageable penumbra are key pathological cascades ischemia-reperfusion injury stroke. Few neuroprotectants can remodel hostile microenvironment for failure interfere with dead or biofunctionally inactive dying cells. Even is temporarily attenuated by medications; insults from still erode continuously along drug metabolism clearance. Herein, a...
Ischemic stroke (IS) constitutes the leading cause of global morbidity and mortality. Neuroprotectants are essential to ameliorate clinical prognosis, but their therapeutic outcomes tremendously compromised by insufficient delivery ischemic lesion intricate pathogenesis associated with neuronal damage, oxidative stress, inflammation responses, blood-brain barrier (BBB) dysfunction, etc. Herein, a biomimetic nanosystem (Leo@NM-Lipo) composed neutrophil membrane-fused nanoliposomal leonurine...