A5065976139- Traumatic Brain Injury and Neurovascular Disturbances
- Catalysis for Biomass Conversion
- Catalysis and Hydrodesulfurization Studies
- Lignin and Wood Chemistry
- Biofuel production and bioconversion
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Neurosurgical Procedures and Complications
- Thermal Regulation in Medicine
- Biodiesel Production and Applications
- Neutrino Physics Research
- Astrophysics and Cosmic Phenomena
- Supercapacitor Materials and Fabrication
- MicroRNA in disease regulation
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- S100 Proteins and Annexins
- Advanced Cellulose Research Studies
- Nanomaterials for catalytic reactions
- Particle physics theoretical and experimental studies
- Neonatal and fetal brain pathology
- Advanced Sensor and Energy Harvesting Materials
- Petroleum Processing and Analysis
- Extracellular vesicles in disease
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Nanjing Forestry University
2019-2024
Shanghai Fire Research Institute
2016-2024
Kyoto University
2021-2024
Institute of Chemical Industry of Forest Products
2015-2024
Xiamen University
2024
Sichuan University
2006-2023
Nanjing Institute of Technology
2023
Chinese Academy of Forestry
2015-2021
Summary Aims Ferroptosis, a new form of iron‐dependent programmed cell death, has been shown to be involved in range diseases. However, the role ferroptosis traumatic brain injury ( TBI ) yet elucidated. We aimed investigate whether is induced after and inhibition would protect against controlled cortical impact CCI mouse model. Methods After establishing model mice, we determined biochemical morphological changes associated with ferroptosis, including iron accumulation Perl's staining,...
Abstract Hyperactivated Ras regulates many oncogenic pathways in several malignant human cancers including glioblastoma and it is an attractive target for cancer therapies. activation cells drives protein internalization via macropinocytosis as a key nutrient-gaining process. By utilizing this unique endocytosis pathway, here we create biologically inspired nanostructure that can induce to ‘drink drugs’ targeting activating transcription factor-5 (ATF5), overexpressed anti-apoptotic factor...
Glial fibrillary acidic protein (GFAP) may serve as a serum marker of traumatic brain injury (TBI) that can be used to monitor biochemical changes in patients and gauge the response treatment. However, temporal profile GFAP acute period associated utility for outcome prediction has not been elucidated.We conducted prospective longitudinal cohort study consecutive severe TBI local tertiary neurotrauma center Shanghai, China, between March 2011 September 2014. All were monitored managed with...
Increasing evidence indicates that activated microglia play an important role in the inflammatory response following traumatic brain injury (TBI). Inhibiting M1 and stimulating M2 have demonstrated protective effects several animal models of central nervous system diseases. However, it is not clear whether polarization to attenuates axonal TBI. In this study, we used a lateral fluid percussion device induce mice. Mice were randomly assigned sham, TBI, TBI + rosiglitazone (peroxisome...
Inspired by animal muscles, we developed a kind of tough elastomers combining high strength and stretchability with autonomous self-healing capability. A key structural feature is the construction double network (DN) connected hydrogen bond host-guest interactions. The first classic elastomer polyacrylate matrix cross-linked strong bonding. second formed through interactions between polycyclodextrin adamantane (Ad) groups on side chain. Supramolecular two networks make them miscible...
Exosomes derived from bone marrow mesenchymal stem cells can inhibit neuroinflammation through regulating microglial phenotypes and promoting nerve injury repair. However, the underlying molecular mechanism remains unclear. In this study, we investigated by which exosomes neuroinflammation. Our in vitro co-culture experiments showed that their promoted polarization of activated BV2 microglia to anti-inflammatory phenotype, inhibited expression proinflammatory cytokines, increased cytokines....
Severe traumatic brain injury (TBI) leads to acute coma and may result in prolonged disorder of consciousness (pDOC). We aimed determine whether right median nerve electrical stimulation is a safe effective treatment for accelerating emergence from after TBI.This randomised controlled trial was performed 22 centres China. Participants with at 7-14 days TBI were randomly assigned (1:1) either routine therapy (RMNS group) or (control group). The RMNS group received 20 mA, 300 μs, 40 Hz pulses,...
Abstract Prognostic prediction of traumatic brain injury (TBI) in patients is crucial clinical decision and health care policy making. This study aimed to develop validate models for in-hospital mortality after severe (sTBI). We developed validated logistic regression (LR), LASSO regression, machine learning (ML) algorithms including support vector machines (SVM) XGBoost models. Fifty-four candidate predictors were included. Model performance was expressed terms discrimination (C-statistic)...
The secondary damage in traumatic brain injury (TBI) can lead to lifelong disabilities, bringing enormous economic and psychological burden patients their families. Mitochondria, as the core mediator of cascade reaction TBI, is an important target prevent spread cell death dysfunction. Thus, therapeutics that accumulate at damaged sites subsequently rescue functions mitochondria would largely improve outcome TBI. Cyclosporine A (CsA), which maintain integrity mitochondrial function, among...
Therapeutic hypothermia may need prolonged duration for the patients with severe traumatic brain injury (sTBI).The Long-Term Hypothermia trial was a prospective, multicenter, randomized, controlled clinical to examine safety and efficacy in adults sTBI. Eligible were 18-65, Glasgow Coma Scale score at 4 8, initial intracranial pressure (ICP) ≥ 25 mm Hg, randomly assigned long-term mild group (34-35 °C 5 days) or normothermia 37 °C. The primary outcome scale (GOS) 6 months. Secondary outcomes...