A5044054993- Neuroinflammation and Neurodegeneration Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Carbon dioxide utilization in catalysis
- Polymer composites and self-healing
- biodegradable polymer synthesis and properties
- Spinal Fractures and Fixation Techniques
- Facial Nerve Paralysis Treatment and Research
- Cerebral Venous Sinus Thrombosis
- Trauma Management and Diagnosis
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Botulinum Toxin and Related Neurological Disorders
- Phagocytosis and Immune Regulation
- Trigeminal Neuralgia and Treatments
- Stress Responses and Cortisol
- Nanoplatforms for cancer theranostics
- Intracerebral and Subarachnoid Hemorrhage Research
Shanghai Changzheng Hospital
2015-2025
Second Military Medical University
2014-2024
Shanghai University
2024
Novem (Netherlands)
2014
The poor drug delivery to cerebral ischemic regions is a key challenge of stroke treatment. Inspired by the intriguing blood–brain barrier (BBB)-penetrating ability 4T1 cancer cells upon their brain metastasis, we herein designed promising biomimetic nanoplatform camouflaging succinobucol-loaded pH-sensitive polymeric nanovehicle with cell membrane (MPP/SCB), aiming promote preferential targeting lesions attenuate ischemia/reperfusion injury. In transient middle artery occlusion (tMCAO) rat...
Apoptotic vesicles (ApoVs) hold great promise for inflammatory regulation and tissue repair. However, little effort has been dedicated to developing ApoV-based drug delivery platforms, while the insufficient targeting capability of ApoVs also limits their clinical applications. This work presents a platform architecture that integrates apoptosis induction, loading, functionalized proteome regulation, followed by modification, enabling creation an apoptotic vesicle system treat ischemic...
Stroke is a leading cause of global mortality and severe disability. However, current strategies used for treating ischemic stroke lack specific targeting capabilities, exhibit poor immune escape ability, have limited drug release control. Herein, we developed an ROS-responsive nanocarrier targeted delivery the neuroprotective agent rapamycin (RAPA) to mitigate brain damage. The consisted sulfated chitosan (SCS) polymer core modified with boronic ester enveloped by red blood cell membrane...
Background: Ischemic stroke is considered a fatal ischemic disease with high mortality and morbidity. Acute cascade of inflammatory reactions, which not only causes vascular degeneration but also leads to neurological disorders. During this period, the rapid response neutrophil-dominated granulocytes releases cytokines chemokines affect tissue repair. Thus, effective regulation neutrophils appears be key in treating major organ injuries associated inflammation. Methods: This study developed...
Neuroinflammation is a major pathophysiological factor that results in the development of brain injury after cerebral ischemia/reperfusion. Downregulation microRNA (miR)-455-5p ischemic stroke has been considered potential biomarker and therapeutic target for neuronal ischemia. However, role miR-455-5p post-ischemia/reperfusion inflammatory response underlying mechanism have not evaluated. In this study, mouse models ischemia/reperfusion were established by transient occlusion middle artery...
The treatment of plantar heel pain is highly challenging. We report ultrasound-guided pulsed radiofrequency (UG-PRF) in the gastrocnemius to treat and minimize safety issues.This study compared UG-PRF with sham 100 patients pain. Primary outcome measures include subscale Foot Health Status Questionnaire (FHSQ-pain) "first step" as measured on a visual analogue scale (VAS-"first-step" pain). secondary FHSQ-foot function general foot health, health related quality life (assessed using Short...
Abstract Chronic itch is clinically correlated with the development of mood disorders such as anxiety and depression. Nonetheless, whether this relevance exists in rodents unknown, evidence demonstrating chronic can affect lacking. The aim study to characterize affective consequences itch, explore potential mechanisms interventional strategy. We subjected mice by repetitive cutaneous treatment acetone diethylether followed water (AEW) that models “dry skin.” After 3 4 weeks AEW treatment,...
Microglia participate in bi-directional control of brain repair after stroke. Previous studies have demonstrated that hydrogen protects ischemia/reperfusion (I/R) by inhibiting inflammation, but the specific mechanism anti-inflammatory effect is poorly understood. The goal our study to investigate whether inhalation high concentration (HCH) able attenuate I/R-induced microglia activation. Eighty C57B/L male mice were divided into four groups: sham, I/R, I/R + HCH and N2/O2 groups. Assessment...
A series of non-isocyanate poly(ether urethane) (PEU) were prepared by an environmentally friendly route based on dimethyl carbonate, diols and a polyether. The effect the chemical structure polyurethane hard segments properties this kind PEU was systematically investigated in work. Polyurethane with different structures first from hexamethylene di-carbamate (BHC) (butanediol, hexanediol, octanediol decanediol). Subsequently, obtained polycondensation polyether soft (PTMG2000). characterized...