A5069132403- Renal Transplantation Outcomes and Treatments
- Autophagy in Disease and Therapy
- Spectroscopy Techniques in Biomedical and Chemical Research
- Metabolism and Genetic Disorders
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Endometriosis Research and Treatment
- Sirtuins and Resveratrol in Medicine
- Pituitary Gland Disorders and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Organ Transplantation Techniques and Outcomes
- Acute Kidney Injury Research
- Heme Oxygenase-1 and Carbon Monoxide
- Uterine Myomas and Treatments
- Antibiotic Resistance in Bacteria
- Botulinum Toxin and Related Neurological Disorders
- Dialysis and Renal Disease Management
- Child Abuse and Related Trauma
- Cervical and Thoracic Myelopathy
- Digestive system and related health
- Neurosurgical Procedures and Complications
- Advanced Glycation End Products research
- Trigeminal Neuralgia and Treatments
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Meningioma and schwannoma management
Second Military Medical University
2015-2025
Second Affiliated Hospital of Jilin University
2016-2025
Changhai Hospital
2015-2025
Shanghai Changzheng Hospital
2014-2015
Novem (Netherlands)
2014
Changchun University of Chinese Medicine
2013
Jilin University
2013
Acute kidney injury (AKI), which involves the loss of function caused by damage to renal tubular cells, is an important public health concern. We previously showed that sirtuin (SIRT)3 protects kidneys against mitochondrial inhibiting nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome, attenuating oxidative stress, and downregulating proinflammatory cytokines. In this article, we investigated role autophagy, mediated a mammalian target rapamycin (mTOR) AMP-activated...
Abstract Acute kidney injury (AKI) is a rapid loss of function characterized by damage to renal tubular cells driven mitochondrial dysregulation and oxidative stress. Here, we used murine caecal ligation puncture (CLP) model sepsis-induced AKI study the role sirtuin 3 (SIRT3), NAD + dependent deacetylase critical for maintenance viability, in AKI-related cell explored underlying mechanisms. CLP induced alterations morphology were associated with SIRT3 downregulation, deletion exacerbated...
Abstract Renal ischaemia‐reperfusion (IR) is a major cause of acute kidney injury (AKI). Cold‐inducible RNA‐binding protein (CIRBP) may contribute to AKI because its deficiency protects against renal IR in mechanism believed involve ferroptosis. We aimed investigate whether ferroptosis associated with CIRBP‐mediated damage. The differential expression CIRBP was examined tubular epithelial (HK2) cells during hypoxia‐reoxygenation (HR) or response erastin, an inducer increased HR erastin HK2...
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney (AKI). Recent findings suggest that Testis-Specific Protein Y-encoded-Like 2 (TSPYL2) plays fibrogenic role in diabetes-associated renal injury. However, the TSPYL2 IRI-induced damage not entirely clear. In this study, we found expression was upregulated mouse model AKI and hypoxia/reoxygenation (H/R) cell model. Knockdown attenuated after IRI. More specifically, knockdown or aminocarboxymuconate-semialdehyde...
Currently, most kidneys from small pediatric deceased donors are transplanted into adult recipients (i.e., PTA). However, due to the weight mismatch, there is a high discard rate and ratio of EBKTs if adopting PTA. Here, we sought both optimize utilization these challenging but scarce donor grafts by selecting characterize feasibility efficacy this PTP allocation strategy. From February 2012 October 2014, 27 infant ≤ 15 kg were procured distributed 38 candidates in our center. The utilized...
Due to the global challenge of donor kidney shortage, expanding pool deceased donors has been proposed include expanded criteria donors. However, lack methods precisely measure injury and predict outcome still leads high discard rates recipient complications. As such, evaluation quality is critical prior transplantation. Biomarkers from urine or serum provide potential advantages for precise quality. Herein, simultaneous detection secretory leukocyte peptidase inhibitor (SLPI) interleukin 18...
Abstract STUDY QUESTION Does oral micronized progesterone result in a non-inferior ongoing pregnancy rate compared to vaginal gel as luteal phase support (LPS) fresh embryo transfer cycles? SUMMARY ANSWER The the group administered 400 mg per day was that 90 day. WHAT IS KNOWN ALREADY LPS is an integrated component of IVF, for which optimal treatment regimen still lacking. high cost and administration route commonly used make it less acceptable than progesterone; however, efficacy unclear...
Key Clinical Message Ovarian leiomyoma and abdominal wall are both rare clinical entities. Here, we report the case with ovarian accompanied by a neglected to raise awareness of clinicians multiple occurrences benign for appropriate diagnosis.
Abstract Background Islet transplantation is used therapeutically in a minority of patients with type 1 diabetes (T1D). However, successful outcomes are hampered by early islet β-cell loss caused immune rejection and autoimmunity. Recent studies have demonstrated that mesenchymal stromal cells can enhance function both vitro vivo secreting ligands activate G-protein coupled receptors (GPCRs). Stromal cell-derived factor (SDF-1) an MSC-secreted GPCR ligand, whereas the suppressor cytokine...
Preservation fluid (PF) contamination, especially by multidrug-resistant (MDR) Gram-negative bacteria (GNB), poses a high risk of donor-derived infection (DDI) and severe clinical outcomes. We sought to determine whether the use colistin sulfate decontaminate PF in kidney transplantation can decrease incidence probable DDI (p-DDI) caused MDR GNB.In retrospective study 916 recipients who received deceased donation, 864 samples were collected cultured, microbiological contaminants recorded...
The aim of this study was to provide a relatively safe operation range for the protection pituitary stalk in transfrontobasal interhemispheric approach craniopharyngioma surgery by measuring related parameters stalk. Based on whole-head magnetic resonance imaging scans 119 healthy subjects (57 men and 62 women) anonymously, three-dimensional reconstructions were rebuilt. results are as follows: M is common midpoint anterior inferior border commissure. O P stalk’s superior extremity,...