A5101521348- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Nanocluster Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Heme Oxygenase-1 and Carbon Monoxide
- Quinazolinone synthesis and applications
- Environmental remediation with nanomaterials
- Autophagy in Disease and Therapy
- Nanomaterials for catalytic reactions
- Actinomycetales infections and treatment
- Advanced Nanomaterials in Catalysis
- Infectious Diseases and Mycology
- Synthesis and Properties of Aromatic Compounds
- Carbon and Quantum Dots Applications
- Organic Electronics and Photovoltaics
- Conducting polymers and applications
- Renal Transplantation Outcomes and Treatments
- Luminescence and Fluorescent Materials
- Advanced oxidation water treatment
- Sirtuins and Resveratrol in Medicine
- Metal-Organic Frameworks: Synthesis and Applications
- Organ Transplantation Techniques and Outcomes
- Diagnosis and treatment of tuberculosis
- Respiratory Support and Mechanisms
- Cytomegalovirus and herpesvirus research
Shanghai Changzheng Hospital
2014-2025
Second Military Medical University
2008-2024
Jiangsu Academy of Agricultural Sciences
2024
Tongji University
2009-2024
Air Force General Hospital PLA
2024
Air Force Medical University
2024
Shanghai Pulmonary Hospital
2016-2024
Southwest Jiaotong University
2023
First People's Hospital of Yunnan Province
2018-2023
Kunming University of Science and Technology
2018-2023
Silicon nanocrystals can provide the outstanding imaging capabilities of toxic heavy-metal-based quantum dots without employing heavy metals and have potential for rapid progression to clinic. Understanding toxicity silicon (SiQDs) is essential realizing this potential. However, existing studies SiQD biocompatibility are limited, with no systematic from small-animal large-animal that more clinically relevant. Here, we test response both mice monkeys high intravenous doses a nanoconstruct...
Printable hydrogels desired in bioengineering have extremely high demands on biocompatibility and mechanic strength, which can hardly be achieved conventional made with biopolymers. Here, we show that employment of the strategy coordination-triggered hierarchical self-assembly naturally occurring small-molecule folic acid, supramolecular robust mechanical elastic modulus comparable to synthetic double-network polymer gels at concentrations below 1%. A sequence steps are involved formation...
Considerable efforts have been devoted to achieving stable acene derivatives for electronic applications; however, the instability is still a major issue such derivatives. To achieve higher stability with minimum structural change, CC units in acenes were replaced isoelectronic BN produce novel BN-embedded tetrabenzopentacene (BNTBP). BNTBP, planar structure, highly air, moisture, light, and heat. Compared its carbon analogue (TBP), embedment lowered highest occupied molecular orbital (HOMO)...
The high viscosity and low fluidity of crude oil impede its adsorption by porous sorbents, making the effective cleanup a significant challenge. Herein, inspired nano-structure of...
Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, has been reported to have beneficial effects on cardiac function. The authors used Langendorff model ischemia/reperfusion (I/R) injury in isolated rat heart determine whether ghrelin exerts direct cardioprotective effects. Also, capacity bind sarcolemmal membrane fractions before and after ischemia reperfusion was examined. Compared with vehicle administration, administration (100-10,000 pM) during period resulted...
Autophagy is an important mechanism for cellular homeostasis and survival during pathologic stress conditions in the kidney, such as ischemia-reperfusion (IR) injury. In this study, renal IR was induced female C57BL/6 mice after melatonin administration. Renal function, histological damage, inflammatory infiltration, cytokine production, oxidative stress, antioxidant capacity, autophagy changing, apoptosis levels, autophagy-associated intracellular signaling pathway were assessed to evaluate...
Well-defined CO-releasing nanomaterial based on atomically precise nanocarrier with light-triggered CO release and good biocompatibility is constructed.
In the field of contemporary medicine, inflammation has emerged as a significant concern in global public health. Among current anti-inflammatory strategies, nanozymes possess distinctive advantages and demonstrate unexpected efficacy combating inflammation. However, indeterminate structures limited enzyme-like activity exhibited by most developed impede their clinical translation therapeutic effectiveness. this paper, we nanozyme derived from well-defined metal-organic cage (MOC). The...
Hepatic ischaemia-reperfusion (IR) injury is a common clinical challenge lacking effective therapy. The aim of this study was to investigate whether spermidine has protective effects against hepatic IR through autophagy. Liver ischaemia reperfusion induced in male C57BL/6 mice. Then, liver function, histopathology, cytokine production and immunofluorescence were evaluated assess the impact pre-treatment on IR-induced injury. Autophagosome formation observed by transmission electron...
Abstract Considerable efforts have been devoted to achieving stable acene derivatives for electronic applications; however, the instability is still a major issue such derivatives. To achieve higher stability with minimum structural change, CC units in acenes were replaced isoelectronic BN produce novel BN‐embedded tetrabenzopentacene (BNTBP). BNTBP, planar structure, highly air, moisture, light, and heat. Compared its carbon analogue (TBP), embedment lowered highest occupied molecular...
We designed customized panel that contains 8 repurposed drugs, including vancomycin (VAN), bedaquiline (BDQ), delamanid (DLM), faropenem (FAR), meropenem (MEM), clofazimine (CLO), cefoperazone-avibactam (CFP-AVI), and cefoxitin (FOX) from the MYCO test system. To better understand efficacy of these drugs against different NTM species, we determined MICs 241 isolates collected in Shanghai, China.
Mycobacterium abscessus complex (MABC) is a group of important infectious agents that are highly associated with drug resistance, and antibiotic treatment usually ineffective. This study investigated the characteristics antimicrobial susceptibility MABC isolates synergy between certain β-lactam combinations against infection.We collected 129 from patients lower respiratory tract infections categorized them into three subspecies. The minimum inhibitory concentrations (MICs) 15 antimicrobials...
Mycobacterium kansasii, an important opportunistic pathogen of humans, causes serious pulmonary disease. Sixty M. kansasii isolates were collected for investigating the clinical characteristics patients with infections as well drug susceptibility and genotypes kansasii. More than 90% infected from eastern China. According to internal transcribed spacers (ITS), rpoB, hsp65, tuf, all classified molecular type I, irrespective disease manifestation. China diverse separated into four branches....
Rationale: As substitutes for natural enzymes, nanozymes offer tunable enzyme-like activities and remarkable structural stability, granting them the potential to treat various diseases, including renal ischemia-reperfusion (I/R) injury. However, majority of developed suffer from unclear structures limited activity profiles, which hinder study their structure-activity relationships, catalytic diversity, mass production, clinical application. Methods: Herein, we introduce an atomically precise...