A5100392751- Tryptophan and brain disorders
- Diet and metabolism studies
- Stress Responses and Cortisol
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Amino Acid Enzymes and Metabolism
- Organ Transplantation Techniques and Outcomes
- Wound Healing and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Gestational Diabetes Research and Management
- Banana Cultivation and Research
- Parkinson's Disease Mechanisms and Treatments
- Catalytic Processes in Materials Science
- Infant Nutrition and Health
- Pharmacological Effects and Toxicity Studies
- Fetal and Pediatric Neurological Disorders
- Plant Pathogens and Fungal Diseases
- Drug Transport and Resistance Mechanisms
- Mesenchymal stem cell research
- Research on scale insects
- COVID-19 Impact on Reproduction
- Tuberculosis Research and Epidemiology
Chongqing Medical University
2016-2025
People's Hospital of Bishan District
2025
Dalian Medical University
2018-2025
Second Affiliated Hospital of Chongqing Medical University
2018-2025
Children's Hospital of Chongqing Medical University
2017-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2024
Nantong Maternity and Child Health Hospital
2023
Nantong University
2023
Xinyu University
2022
First Affiliated Hospital of University of South China
2022
Abstract Gut microbiota has an important role in the immune system, metabolism, and digestion, a significant effect on nervous system. Recent studies have revealed that abnormal gut induces behaviors, which may be associated with hypothalamic–pituitary–adrenal (HPA) axis. Therefore, we investigated behavioral changes germ-free (GF) mice by tests, quantified basal serum cortisol levels, examined glucocorticoid receptor pathway genes hippocampus using microarray analysis followed real-time PCR...
Major depressive disorder (MDD) is a common mood disorder. Gut microbiota may be involved in the pathogenesis of depression via microbe-gut-brain axis. Liver vulnerable to exposure bacterial products translocated from gut portal vein and In this study, germ-free mice underwent fecal transplantation MDD patients healthy controls. Behavioral tests verified model. Metabolomics using gas chromatography-mass spectrometry, nuclear magnetic resonance, liquid spectrometry determined influence...
Abstract Background The chronic unpredictable mild stress (CUMS) model has long been considered the best for exploring pathophysiological mechanisms underlying depression. However, there are no widely recognised standards strategies modeling and behavioral testing. present study aimed to optimize protocols food deprivation sucrose preference test (SPT) CUMS model. Methods We first evaluated effects of different periods on body weight Sprague Dawley (SD) rats by testing 24 hours (8:00‐8:00 +...
Major depressive disorder is a serious mental with high morbidity and mortality. The role of social stress in the development depression remains unclear. Here, we used defeat paradigm to induce depression-like behavior rats, then evaluated rats measured metabolic changes prefrontal cortex using gas chromatography-mass spectrometry. Within first week after procedure, sucrose preference test (SPT), open field (OFT), elevated plus maze (EPM) forced swim (FST) were conducted examine...
Abstract Women are more vulnerable to major depressive disorder (MDD) than men. However, molecular biomarkers of sex differences limited. Here we combined gas chromatography–mass spectrometry (GC–MS)- and nuclear magnetic resonance (NMR)-based metabonomics investigate urinary metabolite markers in MDD, further explore their potential diagnosing MDD. Consequently, the signatures women men MDD subjects were significantly different from that respective healthy controls (HCs). Twenty seven 36...
The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients misdiagnosed as having major depression. Therefore, it is very important correctly diagnose during depressive episode. Here, we conducted this study identify potential biomarkers for young and middle-aged Both gas chromatography-mass spectroscopy (GC-MS) nuclear magnetic resonance (NMR) were used profile the urine samples from recruited subjects. In total, 13...
Currently, most kidneys from small pediatric deceased donors are transplanted into adult recipients (i.e., PTA). However, due to the weight mismatch, there is a high discard rate and ratio of EBKTs if adopting PTA. Here, we sought both optimize utilization these challenging but scarce donor grafts by selecting characterize feasibility efficacy this PTP allocation strategy. From February 2012 October 2014, 27 infant ≤ 15 kg were procured distributed 38 candidates in our center. The utilized...
Abstract Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the of DG venlafaxine (VLX) social defeat stress model depression. Both VLX attenuated stress-induced deficits, despair behaviour exploratory behaviour. To elucidate metabolic changes underlying antidepressive VLX, investigated candidate...
The purpose of this study was to predict the carcass characteristics broilers using support vector regression (SVR) and artificial neural network (ANN) model methods. Data were obtained from 176 yellow feather aged 100-day-old (90 males 86 females). input variables live body measurements, including external measurements B-ultrasound measurements. predictors weight abdominal fat breast muscle in male female broilers, respectively. After descriptive statistics correlation analysis, datasets...