A5100655070- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Treatment of Major Depression
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Stress Responses and Cortisol
- Gut microbiota and health
- RNA modifications and cancer
- Retinal and Macular Surgery
- Ubiquitin and proteasome pathways
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Glaucoma and retinal disorders
- Gene expression and cancer classification
- Diet and metabolism studies
- Retinal Diseases and Treatments
- Metabolomics and Mass Spectrometry Studies
- Insect-Plant Interactions and Control
- Marine and coastal ecosystems
- Insect Pest Control Strategies
- Insect behavior and control techniques
- Intraocular Surgery and Lenses
- Circular RNAs in diseases
- Microbial Community Ecology and Physiology
- Insect symbiosis and bacterial influences
Harbin Medical University
2008-2025
Sichuan University
2021-2025
West China Hospital of Sichuan University
2025
ZheJiang Academy of Agricultural Sciences
2022-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2025
Chongqing Medical University
2015-2024
Nanjing Agricultural University
2022-2024
Shihezi University
2021-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2024
Qingdao University
2024
The prokaryotic type II CRISPR/Cas9 system has been adapted to perform targeted genome editing in cells and model organisms. Here, we describe gene deletion replacement human via the using two guide RNAs. effectively generated deletions of varied length, regardless transcriptional status target gene. It is notable that RNAs resulted formation correct junctions at high efficiency. Moreover, presence a homology repair donor, could precise replacement. Our results illustrate can be used...
Abstract Extensive research has been carried out on the metabolomic changes in animal models of depression; however, there is no general agreement about which metabolites exhibit constant changes. Therefore, aim this study was to identify consistently altered large-scale metabolomics studies depression models. We performed vote counting analyses upregulated or downregulated brain, blood, and urine based 3743 differential from 241 studies. found that serotonin, dopamine, gamma-aminobutyric...
Neuroinflammation and autophagy are implicated in stress-related major depressive disorder (MDD), but the underlying molecular mechanisms remain largely unknown.
Neuroinflammation is tightly associated with onset of depression. The nuclear receptor related 1 protein (Nurr1, also called Nr4a2), its roles in dopaminergic neurons well understood, which can alleviate inflammation. Nevertheless, potential effects Nr4a2 on neuroinflammation depression still remains unclear. Chronic lipopolysaccharides (LPS) stress induced depressive-behaviors were confirmed via behavioral tests. Differentially expressed genes detected by using RNA-sequencing. anterior...
Abstract Our previous work has shown that d -ribose (RIB)-induced depressive-like behaviors in mice. However, the relationship between variations RIB levels and depression as well potential participation depressive disorder is yet unknown. Here, a reanalysis of metabonomics data from depressed patients model rats performed to clarify whether increased level positively correlated with severity depression. Moreover, we characterize intestinal epithelial barrier damage, gut microbial...
Abstract Inhibition of jasmonic acid (JA) signaling renders plants more susceptible to biotic stresses. Pathogen infection can induce an increase in JA levels. However, our understanding the mechanisms mediating pathogen-induced accumulation rice (Oryza sativa) remains limited. We characterized OsLOX9, a lipoxygenase gene 13-LOX subfamily involved biosynthesis, which is induced upon by blast fungus Magnaporthe oryzae. Two independent lox9 mutants exhibited increased susceptibility M. oryzae...
Abstract Motivation: Differentially expressed gene (DEG) lists detected from different microarray studies for a same disease are often highly inconsistent. Even in technical replicate tests using identical samples, DEG detection still shows very low reproducibility. It is believed that current small will largely introduce false discoveries. Results: Based on statistical model, we show even it likely the selected be inconsistent presence of measurement variations. Therefore, apparently...
Abstract Numerous studies have investigated metabolite alterations resulting from pharmacological treatment in depression models although few quantitative explored metabolites exhibiting constant alterations. This study aimed to identify consistently dysregulated across such using a knowledgebase-driven approach. was based on 157 that identified an assembly of 2757 differential the brain, blood, urine, liver, and feces samples with medication. The use vote-counting approach upregulated...
A decade of studies on middle cortex (MC) formation in the root endodermis Arabidopsis (Arabidopsis thaliana) have revealed a complex regulatory network that is orchestrated by several GRAS family transcription factors, including SHORT-ROOT (SHR), SCARECROW (SCR), and SCARECROW-LIKE3 (SCL3). However, how their functions are regulated remains obscure. Here we show mutations SEUSS (SEU) gene led to higher frequency MC formation. seu mutants had strongly reduced expression SHR, SCR, SCL3,...
Breast cancer is the leading cause of women death.Heat shock protein 90 (HSP90) and Histone deacetylase 6 (HDAC6) are promising anti-cancer drug targets.However, it's still unclear applicability anti-HSP90 anti-HDAC6 strategies in precision treatment breast cancer.In current study, we found that triple negative (TNBC) cells, compared to T47D, an ERα+ cell line, exhibited 7~40 times lower IC 50 values, stronger cycle perturbation, increased apoptosis inhibition migration upon 17-DMAG...
Abstract Nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) are global epidemic public health problems with pathogenesis incompletely understood. Hepatocyte excessive apoptosis is a significant symbol for NAFLD/NASH patients, and therefore anti-apoptosis therapy could be used treatment. Up-regulation of BCL-2 has been found to closely related anti-apoptosis. gene promoter region C-rich sequence, which can form i-motif structure play important role in regulating...
Abstract Background Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including antioxidative, anti-inflammatory, anticancer, neuroprotective and senescent cell-clearing activities. It has been shown to effectively alleviate neurodegenerative diseases enhance cognitive functions various models. The immune system implicated the regulation of brain function abilities. However, it remains unclear whether quercetin enhances by interacting...
Abstract The two‐spotted spider mite ( Tetranychus urticae ) is one of the most well‐known pesticide‐resistant agricultural pests, with resistance often attributed to changes such as target‐site mutations and detoxification activation. Recent studies show that pesticide can also be influenced by symbionts, but their involvement in this process mites remains uncertain. Here, we found infection Wolbachia , a bacterial reproductive manipulator, significantly increased survival after exposure...
Abstract Background Hundreds of genes that are causally implicated in oncogenesis have been found and collected various databases. For efficient application these abundant but diverse data sources, it is fundamental importance to evaluate their consistency. Results First, we showed the lists cancer from some major sources were highly inconsistent terms overlapping genes. In particular, most accumulated previous small-scale studies could not be rediscovered current high-throughput genome...
miR-1290 is a newly discovered microRNA (miRNA), and its role in non-small cell lung cancer (NSCLC) remains unknown. This study aimed to evaluate the expression levels of NSCLC tissues serum, explore associations with clinicopathological characteristics prognosis patients.A total 33 pairs 73 serum samples were obtained from patients detected by specific TaqMan qRT-PCR. The relationship between was estimated respectively. correlation overall survival performed Kaplan-Meier analysis Cox...
The pineapple (Ananas comosus) is cold sensitive. Most cultivars are injured during winter periods, especially in sub-tropical regions. There a lack of molecular information on the pineapple's response to stress. In this study, high-throughput transcriptome sequencing and gene expression analysis were performed plantlets cold-tolerant genotype cultivar 'Shenwan' before after treatment. A total 1,186 candidate responsive genes identified, their credibility was confirmed by RT-qPCR. Gene set...
The importance of long noncoding RNA (lncRNA) in tumorigenesis has been supported by increasing evidence recent years. However, the mechanism linking lncRNA function with cancer progression remains poorly understood. LCPAT1 plays a role lung cancer. how it works breast (BC) is largely unclear. In this study, we found that was highly expressed BC tissues and cell lines. High expression predicted low survival rate patients. promoted proliferation, migration, invasion while inhibiting apoptosis...