A5101786254- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
- Cardiac Ischemia and Reperfusion
- Spine and Intervertebral Disc Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare and Venom Research
- Neuropeptides and Animal Physiology
- Musculoskeletal pain and rehabilitation
- Vagus Nerve Stimulation Research
- Neuroscience and Neuropharmacology Research
- Respiratory Support and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Shoulder Injury and Treatment
- Pain Management and Treatment
- Immune Response and Inflammation
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Myofascial pain diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
Shanghai East Hospital
2020-2025
Nankai University
2025
Tongji University
2018-2024
National Clinical Research Center for Digestive Diseases
2024
Xi'an Jiaotong University
2024
Shanghai Jiao Tong University
2010-2019
Renji Hospital
2010-2019
National Natural Science Foundation of China
2016
Second Military Medical University
2015
Fudan University
2008
Background Remimazolam, an ultra-short-acting benzodiazepine, may provide adequate sedation for endoscopy while causing less cardiovascular or respiratory disturbance than propofol. Although fixed-dose administration is suggested, body weight affects the volume of central chamber and thus depth that can be achieved by first dose. This study aimed to compare efficacy safety different doses remimazolam propofol during gastroscopy. Methods multicenter, randomized, single-blind,...
Background Recent advances have indicated a complex interplay between the autonomic nervous system and innate immune system. Targeting neural networks for treatment of sepsis is being developed as therapeutic strategy. Because electroacupuncture at select acupoints can modulate activities system, we tested hypothesis that specific could systemic inflammatory responses improve survival via its impact on in rat model sepsis. Methods Sprague-Dawley male rats received 45 min before 1, 2, or 4 h...
Electroacupuncture (EA) has therapeutic effects on neuropathic pain induced by nerve injury; however, the underlying mechanisms remain unclear. In this study, we examined whether EA treatment relieves hypersensitivity via down-regulation of spinal P2X7 receptor-positive (P2X7R⁺) microglia-mediated overexpression interleukin (IL)-1β and/or IL-18.Male Sprague-Dawley rats underwent chronic constriction injury (CCI) or 3'-O-(4-benzoylbenzoyl) adenosine 5'-triphosphate (BzATP) intrathecal...
Background: Pudendal neuralgia is an intractable pain related to the pudendal nerve. The clinical effect and safety evaluation of were investigated by pulse radiofrequency (PRF) treatment Patients methods: Eighty patients who diagnosed with randomly divided into PRF group (PRF nerve block [NB]) NB group. After surgery, followed up evaluate visual analog scale (VAS) score Patient Health Questionnaire on postoperative day at 2 weeks, 1 3 months. Meanwhile, patients' efficacy assessment usage...
Although many studies have shown that isoflurane exposure impairs spatial memory in aged animals, there are no clinical treatments available to prevent this deficit. The anticholinergic properties of volatile anesthetics a biologically plausible cause cognitive dysfunction elderly subjects. We hypothesized pretreatment with the acetylcholinesterase inhibitor donepezil, which has been approved by Food and Drug Administration (FDA) for treatment Alzheimer's disease, prevents isoflurane-induced...
Abstract Excessive release of high mobility group box-1 (HMGB1) protein from ischemic cardiomyocytes activates inflammatory cascades and enhances myocardial injury after reperfusion. Here we report evidence that electroacupuncture mice at Neiguan acupoints can inhibit the up-regulation cardiac HMGB1 following ischemia attenuate associated responses during These benefits were partially reversed by administering recombinant to further potentiated anti-HMGB1 antibody. Electroacupuncture-induced...
Objective. To compare ultrasound-guided miniscalpel-needle (UG-MSN) release versus dry needling (UG-DN) for chronic neck pain. Methods. A total of 169 patients with pain were randomized to receive either UG-MSN or UG-DN. Before treatment and at 3 6 months posttreatment, was measured using a 10-point visual analogue scale (VAS). Neck function examined the disability index. Health-related quality life physical component score (PCS) mental (MCS) SF-36 health status scale. Results. Patients in...
Protein SUMOylation (SUMO is small ubiquitin-related modifier) a dynamic process that strictly regulated under physiological and pathological conditions. However, little known about how various intra- or extra-cellular stimuli regulate expression levels of components in the SUMO system. isoforms SUMO2 SUMO3 can rapidly convert to be conjugated response variety cellular stresses. Owing limitations sequence homology, cannot differentiated between are thus referred as SUMO2/3. Whether these two...
In Brief BACKGROUND: Our previous studies demonstrated that intrathecal lidocaine treatment could produce prolonged reversal of established hyperalgesia or allodynia, both induced by chronic constriction injury. Indeed, remarkably suppressed the activation p38 mitogen-activated protein kinase (MAPK) in hyperactive microglia. present study we suggest may act directly on microglia and attenuate release cytokines. METHODS: We assessed influence levels phospho-p38 MAPK, tumor necrosis factor-α...