A5080535482- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Immune cells in cancer
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- interferon and immune responses
- Asthma and respiratory diseases
- Gout, Hyperuricemia, Uric Acid
- Cancer Immunotherapy and Biomarkers
- Cytomegalovirus and herpesvirus research
- Heme Oxygenase-1 and Carbon Monoxide
- Pediatric health and respiratory diseases
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Crystallization and Solubility Studies
- Phagocytosis and Immune Regulation
- NF-κB Signaling Pathways
- Galectins and Cancer Biology
- Toxoplasma gondii Research Studies
Jilin Agricultural University
2025
Zhongshan Hospital of Xiamen University
2024-2025
Xiamen University
2021-2024
National Institutes of Health
2015-2023
National Institute of Allergy and Infectious Diseases
2015-2023
Center for Excellence in Molecular Cell Science
2008-2015
Chinese Academy of Sciences
2004-2015
Shanghai Institutes for Biological Sciences
2008-2015
Inflammatory ILC2s are itinerant sentinels Group 2 innate lymphoid cells (ILC2s) a population of immune that play important roles in tissue homeostasis and barrier immunity to helminths. Recent work has suggested primarily long-term residents tissues do not readily recirculate. Huang et al. now demonstrate, however, these findings necessarily hold true for the interleukin-25 (IL-25)–responsive KLRG1 hi “inflammatory” ILC2 (iILC2) subset (see Perspective by Mjösberg Rao). In response...
T helper type 2 (Th2) cytokine-activated M2 macrophages contribute to inflammation resolution and wound healing. This study shows that IL-4-primed exhibit a stronger response lipopolysaccharide stimulation while maintaining signature gene expression. Metabolic divergence between canonical non-canonical proinflammatory-prone (M2INF) occurs after the IL-4Rα/Stat6 axis. Glycolysis supports Hif-1α stabilization proinflammatory phenotype of M2INF macrophages. Inhibiting glycolysis blunts...
Abstract The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is critical for caspase-1 activation and the proteolytic processing of pro–IL-1β. However, mechanism that regulates NLRP3 remains unclear. In this paper, we demonstrate tripartite-motif protein 30 (TRIM30) negatively activation. After stimulation with ATP, an agonist inflammasome, knockdown TRIM30 enhanced increased production IL-1β in both J774 cells bone marrow-derived macrophages. Similarly triggered by other...
T follicular helper (Tfh) cells express transcription factor BCL-6 and cytokine IL-21. Mature Tfh are also capable of producing IFN-γ without expressing the Th1 T-bet. Whether this IFN-γ–producing population represents a unique subset with distinct differentiation pathway is poorly understood. By using T-bet fate–mapping mouse strains, we discovered that almost all have previously expressed high levels NKG2D. DNase I hypersensitivity analysis indicated Ifng gene locus partially accessible in...
Abstract Viral infection causes host cells to produce type I IFNs, which play a critical role in viral clearance. IFN regulatory factor (IRF) 7 is the master regulator of IFN-dependent immune responses. In this article, we report that N-Myc and STATs interactor (Nmi), Sendai virus–inducible protein, interacted with IRF7 inhibited virus-triggered production. The overexpression Nmi virus–triggered induction whereas knockdown promoted Furthermore, enhanced production IFNs resulting from was...
Th cell differentiation is precisely regulated by thousands of genes at different stages. In the present study, we demonstrate that Dec2, a transcription factor belonging to bHLH (basic helix-loop-helix) superfamily, progressively induced during course Th2 differentiation, especially late stage. The up-regulated Dec2 can strongly promote development under Th2-inducing conditions, as evidenced retrovirus-mediated gene transfer or transgenic manipulation. addition, an enhancement responses...
Local immunoinflammatory events instruct skeletal stem cells (SSCs) to repair/regenerate bone after injury, but mechanisms are incompletely understood. We hypothesized that specialized Regulatory T (Treg) necessary for repair and interact directly with SSCs through organ-specific messages. Both in human patients fracture mouse model of we identified a injury-responding Treg subpopulation bone-repair capacity marked by CCR8. production CCL1 induced massive migration CCR8+ from periphery the...
The existing single-pulse search algorithms for fast radio bursts (FRBs) do not adequately consider the frequency bandpass pattern of pulse, rendering them incomplete relatively narrow-spectrum detection pulses. We present a new algorithm narrow-band pulses to update standard pipeline, Bandpass-Adaptive Single-pulse SEarch Toolkit (BASSET). BASSET employs time-frequency correlation analysis identify and remove noise involved by zero-detection band, thereby enhancing signal-to-noise ratio...
Background TGF-β has been postulated to play an important role in the maintenance of epithelial homeostasis and development epithelium-derived cancers. However, most previous studies are mainly focused on function immune cells allergic asthma how signaling airway epithelium itself inflammation is largely unknown. Furthermore, vivo specifically during lung cancer elusive. Methodology/Principal Findings To evaluate contribution disease cancer, we generated a transgenic mouse model with Smad7,...
Abstract Inflammasomes are multiprotein complexes that trigger the activation of caspase-1 and maturation IL-1β, which critical for inflammation control pathogen infection. Although function inflammasomes in immune response disease development is well studied, molecular mechanism by activated assembled remains largely unknown. In this study, we found β-arrestin1, a key regulator G protein–coupled receptor signaling pathway, was required nucleotide-binding domain leucine-rich repeat...
Lymphoid tissue inducer (LTi) cells, a subset of innate lymphoid cells (ILCs), play an essential role in the formation secondary tissues. However, regulation development and functions this ILC is still elusive. In study, we report that transcription factor T cell 1 (TCF-1), just as GATA3, indispensable for non-LTi subsets. While LTi are present TCF-1-deficient mice, organogenesis Peyer's patches (PPs), but not lymph nodes, impaired these mice. from different tissues have distinct gene...
Type 1 conventional dendritic cells (cDC1) are the most efficient cross-presenting that induce protective cytotoxic T cell response. However, regulation of their homeostasis and function is incompletely understood. Here we observe a selective reduction splenic cDC1 accompanied by excessive death in mice with Zeb1 deficiency cells, rendering more resistant to Listeria infection. Additionally, from other sources Zeb1-deficient display impaired cross-presentation exogenous antigens,...
Immunoglobulin A (IgA)-producing plasma cells derived from conventional B in the gut play an important role maintaining homeostasis of flora. Both T cell-dependent and cell-independent IgA class switching occurs lymphoid structures gut, whose formation depends on tissue inducers (LTis), a subset innate (ILCs). However, our knowledge functions non-LTi helper-like ILCs, counter parts CD4 helper cells, promoting production is still limited. By cell adoptive transfer utilizing unique mouse...
A freshly cleaved mica surface silanized by 3-aminopropyl triethoxysilane is flat over a large area, displays controlled degree of hydrophobicity and contains positive charges. In this paper, sheets method have been used as crystallization surfaces for lysozyme, trichosanthin three other proteins unknown structure. Crystallization experiments carried out the hanging-drop vapour-diffusion technique results indicate that can ameliorate protein process considerably compared with glass cover...