A5101543633- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Cardiac and Coronary Surgery Techniques
- Breast Cancer Treatment Studies
- Peptidase Inhibition and Analysis
- Blood groups and transfusion
- Ureteral procedures and complications
- Pediatric Urology and Nephrology Studies
- Gut microbiota and health
- Cancer Research and Treatments
- Urological Disorders and Treatments
- Ubiquitin and proteasome pathways
- Protease and Inhibitor Mechanisms
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Natural Products and Biological Research
- Male Breast Health Studies
- Climate change and permafrost
- Quantum-Dot Cellular Automata
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- PARP inhibition in cancer therapy
- Medical Research and Treatments
- Bioactive Compounds in Plants
Southern Medical University
2023-2025
Institute of Soil and Water Conservation
2024-2025
Guangdong University of Technology
2024-2025
Guangdong Pharmaceutical University
2024-2025
Changchun Institute of Applied Chemistry
2025
Chinese Academy of Sciences
2025
State Key Laboratory of Rare Earth Resources Utilization
2025
Northwest A&F University
2024
Hebei North University
2023-2024
Huaqiao University
2012-2023
Recent reports have suggested the involvement of gut microbiota in progression colorectal cancer (CRC). We utilized pyrosequencing based analysis 16S rRNA genes to determine overall structure patients with and healthy controls; we investigated intestinal lumen, cancerous tissue matched noncancerous normal tissue. Moreover, mucosa-adherent microbial composition using rectal swab samples because tissue-adherent bacterial community is potentially altered following bowel cleansing. Our findings...
Liver fibrosis is a disease largely driven by resident and recruited macrophages. The phenotypic switch of hepatic macrophages can be achieved chemo-attractants cytokines. During screening plants traditionally used to treat liver diseases in China, paeoniflorin was identified as potential drug that affects the polarization aim this study evaluate therapeutic effects an animal model explore its underlying mechanisms. induced Wistar rats via intraperitoneal injection CCl4. In addition,...
The clinical value of the Syntax score in patients with non-ST segment elevation myocardial infarction (NSTEMI) has been well established. neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), high sensitivity C-reactive protein (hsCRP)-albumin (hsCAR), and systemic immune-inflammatory (SII) index are promising inflammation (SI) biomarkers coronary artery diseases. However, studies which compare predicting these SI indicators NSTEMI limited.NSTEMI who underwent angiography (CAG) our...
Th cell differentiation is precisely regulated by thousands of genes at different stages. In the present study, we demonstrate that Dec2, a transcription factor belonging to bHLH (basic helix-loop-helix) superfamily, progressively induced during course Th2 differentiation, especially late stage. The up-regulated Dec2 can strongly promote development under Th2-inducing conditions, as evidenced retrovirus-mediated gene transfer or transgenic manipulation. addition, an enhancement responses...
To investigate the mechanism by which Biejiajian Pill (BJJP) regulates ferroptosis in hepatocellular carcinoma (HCC) cells through p62/Keap1/NRF2 pathway and to provide an experimental basis for its application prevention treatment of HCC. Huh7 HCC were divided into a normal control group, BJJP drug serum erastin (a inducer) + ferrostatin-1 (Fer-1) inhibitor) group. was prepared with animals treated CCK-8 assay performed determine optimal concentration duration intervention. The levels...
The activation of the cyclic GMP‐AMP synthase‐stimulator interferon genes (cGAS‐STING) pathway has shown promise in enhancing antitumor immunity. However, involved de novo transcription and translation processes, which delays immune responses. Besides, rapid clearance secondary messenger (cGAMP) by extracellular hydrolase limits its availability, attenuating STING signaling resulting insufficient therapeutic efficacy. Herein, we constructed a DNA‐based nanocomplex, could restore cell‐cell...
The activation of the cyclic GMP‐AMP synthase‐stimulator interferon genes (cGAS‐STING) pathway has shown promise in enhancing antitumor immunity. However, involved de novo transcription and translation processes, which delays immune responses. Besides, rapid clearance secondary messenger (cGAMP) by extracellular hydrolase limits its availability, attenuating STING signaling resulting insufficient therapeutic efficacy. Herein, we constructed a DNA‐based nanocomplex, could restore cell‐cell...
ABSTRACT Aim Nitrogen (N) deposition and climate warming are the two most important factors driving soil N 2 O emissions in terrestrial ecosystems. Both biotic abiotic impact cycling processes functional gene abundances, but their global responses patterns to mineral addition regulatory affecting remain unclear. Location Global. Time Period 1986–2022. Major Taxa Studied Soil emission, abundances edaphic factors. Methods We synthesised 5299 observations of processes, under from 357...
Abstract Adverse skin reactions caused by ionizing radiation are collectively called dermatitis (RD), and the use of nanomedicine is an attractive approach to this condition. Therefore, we designed large-scale synthesized fullerenols that showed free radical scavenging ability in vitro. Next, pretreated X-ray-exposed cells with fullerenols. The results pretreatment significantly scavenged intracellular reactive oxygen species (ROS) produced enhanced antioxidant capacity, protecting from...
Conventional therapeutic approaches for cancer are limited by cell resistance, which has impeded their clinical applications. The main goal of this work was to investigate the combined antitumor effect paclitaxel with small interfering RNA modified cationic liposome formed from octadecyl quaternized carboxymethyl chitosan. composed 3β-[N-(N′, N′-dimethylaminoethane)-carbamoyl]-cholesterol, dioleoylphosphatidylethanolamine, and properties were characterized Fourier transform infrared...
Breast cancer is the most common malignant tumor affecting women worldwide and divided into following subtypes: Luminal A, B, HER‑2 overexpression triple‑negative breast (TNBC). TNBC accounts for approximately 15‑20% of all cases. Due to characteristics low differentiation, likelyhood recurrence metastasis, strong invasiveness lack hormone receptors human epidermal growth factor receptor 2 (HER2), patients with cannot benefit from endocrine therapy or other available targeted agents....
A lateral flow immunoassay (LFIA) based on Au@PdPt NPs was developed to detect and type the HPV16 HPV18 simultaneously.
Cardiac tamponade is a critical cardiovascular condition where timely diagnosis and treatment are crucial. The formation of an intrapericardial hematoma following acupuncture therapy clinically rare. This paper reports case elderly female patient who experienced severe chest pain syncope during therapy, subsequently diagnosed with traumatic hemopericardium acute cardiac tamponade, complicated by cardiogenic shock. Under ultrasound guidance, pericardial puncture drainage were successfully...
To explore the natural history of and risk factors for gastroesophageal reflux (GER) in a prospective cohort Beijing, China.We selected adult participants using stratified randomized method performed initial surveys 1996 current survey 2008. Well-trained investigators administered questionnaire face-to-face interviews. Reflux symptoms were evaluated by their intensity frequency. GER was defined as heartburn, acid reflux, food regurgitation at least once week, monthly one above occurring 1-3...
Numerous studies have shown that young age is a risk factor in early breast cancer.But for stage IV cancer, it unclear whether has similar effect on patient survival.We collected and analyzed data from patients with cancer between January 2010 December 2015 SEER database.Multivariate Cox proportional hazard model was used this study.13,069 were included the analysis, of which 1,135 (≤40 years old).In multivariate analysis adjusted sociodemographic factors, clinical-pathological...
Objective To investigate the levels and clinical value of peripheral blood CD154 CD4+CD25+FoxP3+ regulatory T cells in patients with ankylosing spondylitis (AS).Methods 20 AS healthy donors were studied.Flow cytometry was used to analyze CD154,CD4+CD25+FoxP3+ HLA-B27.And T-test,Spearman correlation analysis statistical analysis.Results The level significantly higher than that normal controls [(4.38 ± 1.64) ％ vs.(1.92 1.13) (t =5.836,P ＜ 0.05)],and lower [(3.87 1.11) vs.(6.30 1.46) =6.254,P...