A5010184929- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Natural product bioactivities and synthesis
- Biosensors and Analytical Detection
- Effects and risks of endocrine disrupting chemicals
- Animal health and immunology
- Crystallization and Solubility Studies
- Natural Antidiabetic Agents Studies
- Electrochemical sensors and biosensors
- Inflammatory mediators and NSAID effects
- Pharmaceutical and Antibiotic Environmental Impacts
- Phytochemistry and Biological Activities
- Monoclonal and Polyclonal Antibodies Research
- X-ray Diffraction in Crystallography
- Phytochemicals and Antioxidant Activities
- Insect Pest Control Strategies
- Microplastics and Plastic Pollution
- Eicosanoids and Hypertension Pharmacology
- Mosquito-borne diseases and control
- Pesticide Exposure and Toxicity
- Hormonal Regulation and Hypertension
- Analytical Chemistry and Chromatography
- Chromatography in Natural Products
- Glycosylation and Glycoproteins Research
- Protein purification and stability
Guangdong University of Technology
2016-2025
Guangdong Pharmaceutical University
2019-2025
Minzu University of China
2021-2024
State Ethnic Affairs Commission
2024
Hohhot First Hospital
2018
Jilin University of Chemical Technology
2018
Wuyi University
2018
Green Chemistry
2018
People's Hospital of Bishan District
2011
Jingning County People's Hospital
2011
The screening strategy based on α-glucosidase inhibition has been widely employed for the discovery of antidiabetic drugs, but it still faces some challenges in practical applications, such as poor stability enzyme, high consumption test compounds, low sensitivity methods and so on. In this work, a bifunctional hybrid enzyme-catalytic metal organic framework reactor (GAA@GOx@Cu-MOF) with flower-shaped globular structure was innovatively prepared via self-assembling (GAA), glucose oxidase...
Ursolic acid (UA) is a major pentacyclic triterpenoid in plants, vegetables and fruits, which has been reported to have potential anti-diabetic activity. Despite various semi-synthetic ursolic derivatives already described, new still need be designed synthesized further improve the In present study, two series of novel UA derivatives, were their structures confirmed. The enzyme inhibition activities semi-synthesized analogues against α-glucosidase screened vitro. results indicated that most...
Herein, a Au-Au/IrO2 nanocomposite with tandem enzyme-mimicking activity was innovatively synthesized, which can show outstanding glucose oxidase (GOx)-like and peroxidase-like simultaneously under neutral conditions. Moreover, Au-Au/IrO2@Cu(PABA) reactor prepared via encapsulation of the in Cu(PABA) metal organic framework. The not only exhibits excellent solvent stability, acid resistance, reusability but also displays better cascade reaction catalytic efficiency (kcat/Km = 148.86 min–1...
In the present work, ZnO quantum dots (QDs) have been prepared by sol-gel method, and performance of QDs has improved. The effect Cd concentration on structural luminescent properties QDs, as well mass ratio trioctylphosphine oxide (TOPO)/octadecylamine (ODA), investigated. Cd-doped hexagonal wurtzite structures are 3 to 6 nm in diameter. When content was increased, QD particle size reduced; this confirmed corresponding ultraviolet-visible spectra. fluorescence intensity simultaneously...
Many strategies have been adopted to constructin vitromyocardium models, which are of great value both drug cardiotoxicity evaluation and cardiovascular development. In particular, the recent rapid development human-induced pluripotent stem cell (hiPSC) technology rise organ-on-a-chip technique provided potential achieve more physiologically relevantin vitromodels. However, recapitulating key role vasculature endothelial layer in action on myocardium models is still challenging. this work,...
Glycocholic acid (GCA) is an important metabolite of bile acids, whose urine levels are expected to be a specific diagnostic biomarker for hepatocellular carcinoma (HCC). A high-throughput immunoassay determination GCA would significant advantage and useful primary diagnosis, surveillance, early detection HCC. Single-chain variable fragment (scFv) antibodies have several desirable characteristics attractive alternative traditional the immunoassay. Because chicken possess single heavy light...
Melanoma is one of the most lethal cancers originating from melanocytes. Its incidence and mortality have been rising rapidly for several decades posed a serious threat to human health. Current melanoma treatments are hindered by scope application, low efficiency, high cost, toxic side effects. Due their affordability minimal effects, natural bioactive compounds derived plants promising candidates treatment. This study aims delve into isolation, purification, characterization potato proteins...
The diisobutyl phthalate (DiBP) hapten containing an amino group was synthesized successfully, and the polyclonal antibody against 4-amino phthalate–bovine serum albumin (BSA) developed. On basis of antibody, a rapid sensitive indirect competitive fluorescence immunoassay (icFIA) has been established to detect DiBP in edible oil samples for first time. Under optimized conditions, quantitative working range icFIA from 10.47 357.06 ng/mL (R2 = 0.991), exhibiting detection limit 5.82 ng/mL. In...