A5100626340- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Glycosylation and Glycoproteins Research
- Osteoarthritis Treatment and Mechanisms
- RNA Interference and Gene Delivery
- Ovarian cancer diagnosis and treatment
- Surgical Sutures and Adhesives
- Proteoglycans and glycosaminoglycans research
- Ginseng Biological Effects and Applications
- 3D Printing in Biomedical Research
- RNA modifications and cancer
- Pregnancy and preeclampsia studies
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Nanoparticle-Based Drug Delivery
- Ectopic Pregnancy Diagnosis and Management
- Ferroptosis and cancer prognosis
- Chemical Synthesis and Reactions
- Pressure Ulcer Prevention and Management
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Pelvic floor disorders treatments
- Microbial Metabolism and Applications
- Tissue Engineering and Regenerative Medicine
Nanjing Tech University
2018-2025
Taipei Veterans General Hospital
2012-2025
National Yang Ming Chiao Tung University
2011-2025
China Medical University
2015-2025
China Medical University Hospital
2015-2025
Wenzhou Medical University
2023-2025
Jiangsu University of Science and Technology
2023-2024
Changchun University of Chinese Medicine
2023-2024
Anhui Agricultural University
2023-2024
Shanghai Children's Medical Center
2024
Physicians have long been calling for an inherent antimicrobial wound dressing, which will be a great progress treating complicated infections. Here, we report novel bioadhesive hydrogel with antibacterial properties prepared by mixing modified hyaluronic acid (HA) and ε-polylysine (EPL). This can effectively kill Gram (+) (−) bacteria its high positive charge density on the surface. The sol–gel transition occurs within seconds via horseradish peroxidase enzymatic cross-linking Schiff base...
High glucose-induced vascular endothelial injury is a major pathological factor involved in non-healing diabetic wounds. To interrupt this process, we design an all-peptide printable hydrogel platform based on highly efficient and precise one-step click chemistry of thiolated γ-polyglutamic acid, glycidyl methacrylate-conjugated arginine-glycine-aspartate sequences. Vascular growth 165-overexpressed human umbilical vein cells are printed using platform, hence fabricating living material with...
Abstract Surgical adhesives are crucial for achieving rapid hemostasis and immediate wound management during clinical interventions. However, developing a tissue adhesive that combines instant strength with biodegradability in dynamic, wet, or hemorrhagic biological environments remains persistent challenge. Here, biodegradable supramolecular robust adhesion to wet surfaces within 5 s is presented. The distinctive synergy of surface‐rich groups the hydrophobic main chain enables surmount...
A bio-fabricated nanocomposite hydrogel can catalyze excessive ROS into needed O 2 and neutralize hypernomic MMPs in the pathological environment to promote diabetic wound healing.
Temperature-sensitive core–shell nanostructures are synthesized by functionalizing a hydroxyl-terminated dendrimer with reversible addition-fragmentation chain transfer (RAFT) polymerization chain-transfer agent. RAFT of N-isopropylacrylamide produces shell around the (see Figure). In aqueous solution, changing temperature 10 °C can reversibly open and close poly(N-isopropylacrylamide) shell. Entrapment temperature-induced liberation pyrene from is demonstrated.
As a popular traditional fermented beverage, kombucha has been extensively studied for its health benefits. However, the science behind anti-inflammatory effect of not well studied, and there is an urgent need to uncover secrets properties kombucha. Here, we investigate kombucha's protective effects against lipopolysaccharide (LPS)-induced sepsis on intestinal microecology in mice. The contents reducing sugars, polyphenols, catechins, organic acids group were identified using various...
Allenone has been identified as a highly effective peptide coupling reagent for the first time. The bond was formed with an α-carbonyl vinyl ester key intermediate, formation and subsequent aminolysis of which proceed spontaneously in racemization-/epimerization-free manner. allenone not only is synthesis simple amides dipeptides but also amenable to fragment condensation solid-phase (SPPS). robustness allenone-mediated showcased incisively by carfilzomib, involved rare N C elongation...
Nanoparticle technologies offer a non-invasive means to deliver basic fibroblast growth factor (bFGF) for the treatment of spinal cord injury (SCI). However, inability bFGF accumulate at site and inefficient penetration across blood-spinal barrier (BSCB) remain challenges. The present study describes dual-targeting liposome (bFGF@Lip-Cp&Rp) with lesion targeting BSCB-penetrating capability SCI treatment. CAQK peptide (Cp) ability R2KC (Rp) were grafted onto liposomes flexible drug delivery...
Microbes, including bacteria, viruses, fungi, and other eukaryotic organisms, are commonly present in multiple organs of the human body contribute significantly to both physiological pathological processes. Nowadays, development sequencing technology has revealed presence composition intratumoral microbiota, which includes Fusobacterium, Bifidobacteria, Bacteroides, shed light on significant involvement progression colorectal cancer (CRC). Here, we summarized current understanding microbiota...
Although several studies indicate that RNA-binding proteins (RBPs) contribute to key steps in a variety of physiological processes and cancer, the detailed biological functions mechanisms remain be determined. By performing bioinformatics analysis using well-established hepatocellular carcinoma (HCC) datasets, we identified set HCC progression-associated RBPs (HPARBPs) found global expression HPARBPs was significantly correlated with patient prognosis. Among 42 HPARBPs, human ribosomal...