A5064598398- Plant Stress Responses and Tolerance
- Soybean genetics and cultivation
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Plant-based Medicinal Research
- Atrial Fibrillation Management and Outcomes
- Cancer-related molecular mechanisms research
- Cardiac Arrhythmias and Treatments
- Natural product bioactivities and synthesis
- Telomeres, Telomerase, and Senescence
- Plant Gene Expression Analysis
- Cell death mechanisms and regulation
- Angiogenesis and VEGF in Cancer
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Bioactive Natural Diterpenoids Research
- Cancer-related gene regulation
- Quinazolinone synthesis and applications
- Andrographolide Research and Applications
- Synthesis of Organic Compounds
- Autophagy in Disease and Therapy
- Biological Activity of Diterpenoids and Biflavonoids
Sichuan Mianyang 404 Hospital
2015-2025
Zhejiang University
2011-2024
China Pharmaceutical University
2011-2024
China International Science and Technology Cooperation
2024
Children's Hospital of Chongqing Medical University
2024
The University of Queensland
2021-2024
Hangzhou City University
2023-2024
Zigong First People's Hospital
2022-2024
Chongqing Medical University
2024
Harbin Institute of Technology
2023
Recent studies have demonstrated the importance of cellular extrinsic factors in aging adult stem cells. However, effects an aged cell-extrinsic environment on mesenchymal cell (MSC) and involved remain unclear. In current study, we examine old rat serum (ORS) MSCs, explore mechanisms Wnt/β-catenin signaling MSC induced by ORS treatment. Senescence-associated changes cells are examined with SA-β-galactosidase staining ROS staining. The proliferation ability is detected MTT assay. surviving...
m6A is a ubiquitous RNA modification in eukaryotes. Transcriptome-wide patterns Arabidopsis have been assayed recently. However, differential between organs not well characterized. Over two-third of the transcripts are modified by m6A. In contrast to recent observation enrichment 5′ mRNA, we find that distributed predominantly near stop codons. Interestingly, 85 % show high methylation extent compared their transcript level. The 290 highly methylated mainly associated with transporters,...
Phytophthora root and stem rot of soybean [Glycine max (L.) Merr.], caused by sojae Kaufmann Gerdemann, is a destructive disease throughout the planting regions in world. Here, we report insights into function underlying mechanisms novel ethylene response factor (ERF) soybean, namely GmERF5, host responses to P. sojae. GmERF5-overexpressing transgenic exhibited significantly enhanced resistance positively regulated expression PR10, PR1-1, PR10-1 genes. Sequence analysis suggested that GmERF5...
Drought and heat stress, especially their combination, greatly affect crop production. Many studies have described transcriptome, proteome phosphoproteome changes in response of plants to drought or stress. However, the study about phosphoproteomic crops combination stress is scare. To understand mechanism maize responses analysis was performed on leaves by using multiplex iTRAQ-based quantitative proteomic LC-MS/MS methods. Five-leaf-stage subjected drought, were collected. Globally, heat,...
After eight-leaf stage, maize is highly sensitive to drought, heat and their combination, which greatly affect its production. In present, it still scare for analyzing response combined drought stress after stage. this study, the content or activity of physical parameters such as H2O2, malondialdehyde (MDA), superoxide dismutase (SOD), ascorbate peroxidase (APX) glutathione reductase (GR) was increased, but quantum efficiency photosystem II (ΦPSII) decreased by combination on The most...
Isoflavone reductase (IFR) is an enzyme involved in the biosynthetic pathway of isoflavonoid phytoalexin plants. IFRs are unique to plant kingdom and considered have crucial roles response various biotic abiotic environmental stresses. Here, we report characterization a novel member soybean isoflavone gene family GmIFR. Overexpression GmIFR transgenic exhibited enhanced resistance Phytophthora sojae. Following stress treatments, was significantly induced by P. sojae, ethephon (ET), abscisic...
Increasing evidences indicate that reactive oxygen species are the main factor promoting stem cell aging. Recent studies have demonstrated coenzyme Q10 (CoQ10) plays a positive role in organ and cellular However, potential for CoQ10 to protect aging has not been fully evaluated, mechanisms of senescence inhibited by still poorly understood. Our previous study had indicated D-galactose (D-gal) can remarkably induce mesenchymal (MSC) through intracellular ROS generation. In this study, we...
It has previously been demonstrated that glucose is important in the process of stem cell aging. However, mechanisms senescence induced by high (HG) remain to be elucidated. The preliminary study indicated D‑galactose mesenchymal (MSCs) present demonstrated, following treatment with 11.0 or 22.0 mM HG for 14 days, significantly promoted MSCs aging and expression levels phosphorylated (p-)phosphatidylinositol 3-kinase/protein kinase B (Akt) p‑mammalian target rapamycin signaling (mTOR) groups...
To uptake calcium ions of mitochondria is significant functional connotation for cells, because in are involved energy production, regulatory signals transfer, and mitochondrial permeability transition pore opening even programmed cell death apoptosis, further playing more roles plant productivity quality. Cytoplasmic access into outer membrane (OMM) from voltage dependent anion-selective channel (VDAC) were absorbed inner (IMM) by uniporter (MCU), rapid (RaM) or ryanodine receptor (mRyR)....
Plant response to environmental stresses is regulated by a complicated network of regulatory and functional genes. In this study, we isolated the putative stress-associated gene GmZFP3 (a C2H2-type Zinc finger protein gene) based on previous finding that it was one two genes located in QTL region between Satt590 Satt567 markers related soybean tolerance drought. Temporal spatial expression analysis using quantitative real-time PCR indicated primarily expressed roots, stems leaf organs at low...
Abstract Autophagy and cellular senescence are two critical responses of mammalian cells to stress may have a direct relationship given that they respond the same set stimuli, including oxidative stress, DNA damage, telomere shortening. Mesenchymal stem (MSCs) emerged as reliable cell sources for transplantation currently being tested in numerous clinical trials. However, effects autophagy on MSC corresponding mechanisms not been fully evaluated. Several studies demonstrated level increases...
Abstract TcpC is a multifunctional virulence factor of uropathogenic E. coli (UPEC). Neutrophil extracellular trap formation (NETosis) crucial anti-infection mechanism neutrophils. Here we show the influence on NETosis and related mechanisms. We in context pyelonephritis mouse model induced by TcpC-secreting wild-type CFT073 (CFT073 wt ) LPS-induced vitro with or recombinant (rTcpC)-treated neutrophils are inhibited. rTcpC enters through caveolin-mediated endocytosis inhibits production ROS,...
Abstract Secoisolariciresinol diglucoside (SDG) is the main component of lignans with various biological activities, including anticancer activity. However, whether SDG has obvious effects on colorectal cancer (CRC) unclear. Pyroptosis, a form programmed cell death, received increasing attention in cancer‐related research. In this study, we aimed to test properties and relatecd functional mechanisms SDG. found that not only inhibited viability HCT116 cells, but also induced cells swell...
Plant basic-leucine zipper (bZIP) transcription factors play important roles in many biological processes and are involved the regulation of salt stress tolerance. Previously, our lab generated digital gene expression profiling (DGEP) data to identify differentially expressed genes a salt-tolerant genotype Glycine soja (STGoGS) salt-sensitive max (SSGoGM). This DGEP revealed that (log2 ratio) GmbZIP110 was up-regulated 2.76-fold 3.38-fold SSGoGM STGoGS, respectively. In present study,...
Mounting evidence suggested that histone H4K20‑specific methyltransferase SET8 is required to maintain the malignant phenotype of various cancer types; however, role in mediating tumor metastasis prostate (PCa) has remained elusive. The present study demonstrated small interfering RNA‑mediated knockdown inhibited invasive potential PCa cell line PC‑3 vitro. Knockdown reduced sphere formation, downregulated E‑cadherin and α‑catenin, upregulated N‑cadherin vimentin expression CaP cells, while...
Plant WRKY transcription factors are active guardians against pathogens insurgency, key components in developmental processes, contributors signal transduction pathways and regulators of diverse biotic abiotic stress responses. In this research, we isolated, cloned functionally characterized a new factor GmWRKY49 from soybean. is nuclear protein which contains two highly conserved domains C2H2 type zinc-finger structure. The normalized expression (log2 ratio) was 2.75-fold 1.90-fold salt...